18. Oral colon cancer targeting by chitosan nanocomposites

Thiolated chitosan

Thiol modifications to chitosan in the form of thiolated chitosan has strong mucoad- hesive properties attributed to the formation of disulfide bonds with cysteine-rich

Oral colon cancer targeting by chitosan nanocomposites 419
Table 18.6 Experimental studies of PEGylated chitosan as antico- lon cancer drug nanocarrier

Candidate	Experiment	Remark	Reference
Paclitaxel and all- trans retinoic acid	Paclitaxel incorporated pullulan acetate nanoparticles were prepared by nanoprecipitation- solvent evaporation method. All-trans retinoic acid incorporated nanoparticles were prepared by dialysis method using methoxypoly(ethylene glycol)-grafted chitosan copolymer Combination nanoparticles were subjected to anticancer testing using CT26 cell line 5-Aminolevulinic acid incorporated PEGylated chitosan nanoparticles were prepared by ion complex formation. Protoporphyrin IX accumulation in the tumor cells and phototoxicity-induced by nanoparticles were assessed using CT26 cells in vitro	The combination nanoparticles show a synergistic antiproliferative effect against CT26 cells	[47]
5-Aminolevulinic acid		The nanoparticles show superior delivery capacity of drug and phototoxicity against tumor cells. The nanoparticles are promising candidates for photodynamic therapy of colon cancer cells	[48]

domains of mucus glycoproteins, leading to an improvement in mucoadhesion [51]. Table 18.8 summarizes the outcome of thiolated chitosan as nanocarrier of antican- cer therapeutics for colon cancer treatment.

10.