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Aleksandr Oparin

Object 1


Aleksandr Oparin, in full Aleksandr Ivanovich Oparin    (born Feb. 18 [March 2, New Style], 

1894, Uglich, near Moscow, Russia—died April 21, 1980), Russian biochemist noted for his studies on 


origin of life

 from chemical matter. By drawing on the insights of chemistry, he extended the 

Darwinian theory of evolution backward in time to explain how simple organic and inorganic materials 

might have combined into complex 

organic compounds

 and how the latter might have formed the 

primordial organism.

When Oparin was nine, his family moved to Moscow because there was no secondary school in their 

village. While majoring in plant physiology at 

Moscow State University

, Oparin was influenced by 

K.A. Timiryazev, a Russian plant physiologist, who had known the English naturalist 

Charles Darwin

The indirect effect of Darwin upon Oparin’s thinking can be found in many of the latter’s writings.

In his postdoctoral days Oparin was influenced also by A.N. Bakh, a botanist. Bakh left Russia at the 

time of the Revolution but later returned. Despite the financial difficulties of the times, the Soviet 

government established a biochemical institute in his honour in 1935 in Moscow; Oparin helped to 

found it and served as its director until his death.

At a meeting of the Russian Botanical Society in the spring of 1922, Oparin first introduced his concept 

of a primordial organism arising in a brew of already formed organic compounds. He stated a number 

of premises that were not popular at the time. For example, according to his hypothesis, the earliest 

organisms were heterotrophic; i.e., they obtained their 


 ready-made from compounds that had 

already been formed in variety and profusion by what are in the laboratory quite ordinary means. Thus, 

at that early stage, these first organisms did not need to synthesize their own food materials in the way 

that present-day plants do. Oparin also emphasized that a high degree of structural and functional 

organization is characteristic of the living state, a point of view that is in opposition to the idea that 

“life” is essentially molecular. He was also farsighted in his observation that living organisms, as open 

systems, must receive energy and materials from outside themselves; they cannot, therefore, be limited 

by the 

second law of thermodynamics

, which is applicable to closed systems in which energy is not 


When Oparin first proposed his hypothesis, the prevailing view was that the first organisms could make 

all of their own organic compounds, and so the negative reaction to his proposal was almost universal. 

With continued retesting, however, his concept has come to be accepted in its main outlines. Although 

the possibility of a natural origin of life had been promulgated for at least 2,500 years, a specific 

formulation had to compete with vitalistic points of view in modern times. Also, 

organic chemistry

necessary for Oparin’s hypothesis, had not been sufficiently developed by the time of the 19th-century 

French pathologist 

Louis Pasteur


Oparin’s various novel premises can be shown to be closely related to one another. What had been 

missing was (1) an explanation of how populations of large, complex molecules of largely 

predetermined structure could have arisen in contrast with the widely held view that the first proteins 

would have been random in structure and (2) an adequate explanation of how a first cell-like system 

might reproduce. When experimental answers to these questions arose from another laboratory, Oparin 

acknowledged them in a forthright manner. These answers consisted essentially of (1) ordered coupling 

of amino acids due to their differing shapes and distribution of 

electric charge

 and (2) the formation of 

buds on microscopic droplets followed by growth of separated buds and cyclical repetition of the 

process. In attempting to test his basic hypothesis, Oparin dealt with coacervate droplets, which are 

microscopic units assembled typically from gelatin and 

gum arabic

, as models of early cells. His 

experiments showed that 


 (biological catalysts) could function more efficiently within the 

boundaries of these artificial cells than they could in ordinary aqueous solution. This demonstration 

helped emphasize the fact that complete cells are important for the action of enzymes and metabolism.

The heterotrophic hypothesis for the origin of life has gained wide attention through Oparin’s efforts. 

He organized the first international meeting of the origin of life in Moscow in 1957 at which 

representatives from 16 countries participated. A second conference was held in 1963 and a third in 

Pont-à-Mousson, Fr., in 1970. Oparin’s definitive work is The Origin of Life on Earth, 3rd rev. ed. 


Although he is best known for his contributions to studies of the origin of life, Oparin also devoted 

considerable effort to enzymology and to the closely related subject of industrial biochemistry. His 

wide interests are reflected in the title of the volume prepared in honour of his 70th birthday, Problems 

in Evolutionary and Industrial Biochemistry. But throughout the 1970s, the centre of his interest 

remained at the A.N. Bakh Institute, where, under his direction, a number of research workers were 

concerned with the problems of the origin of life. Oparin received many decorations, including the 

Order of Lenin

, Hero of Socialist Labour, the Bakh Prize, the Kalinga Prize, and the Mechnikov Gold 


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  • Aleksandr Oparin

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