Bone-fat phenotype in POH
Bone-fat phenotype in POH Bone-fat phenotype in POHOsteoblast differentiation and HOAdipocyte differentiation and leanessMechanisms of bone-fat reciprocity
Rare genetic condition of progressive heterotopic bone formation Rare genetic condition of progressive heterotopic bone formation Defined clinically by cutaneous ossification that progresses to involve deep connective tissues including skeletal muscle and fascia [Kaplan et al., 1994] Most cases are caused by heterozygous inactivating germline mutations in the GNAS gene that encodes the alpha subunit of the G-stimulatory protein of adenylyl cyclase [Shore et al., 2002]
Bone-fat phenotpye in POHOsteoblast differentiation and HOAdipocyte differentiation and leanessMechanisms of bone-fat reciprocity
Bone-fat phenotpye in POH Bone-fat phenotpye in POHOsteoblast differentiation and HOAdipocyte differentiation and leanessMechanisms of bone-fat reciprocity
Bone-fat phenotpye in POH Bone-fat phenotpye in POHOsteoblast differentiation and HOAdipocyte differentiation and leanessMechanisms of bone-fat reciprocity
Unlike other GNAS-based disorders of HO, POH occurs in the absence of obesity and multiple other features of AHO or hormone resistance Unlike other GNAS-based disorders of HO, POH occurs in the absence of obesity and multiple other features of AHO or hormone resistanceImpaired bone-fat reciprocity in soft tissue promotes osteogenesis and antagonizes adipogenesis in POH
Laboratory Laboratory- Nichelle Adegbite
- Jan-Jan Lui
- Elizabeth Russell
- Alec Richardson
- Meiqi Xu
- Josef Kaplan
Collaborators
Do'stlaringiz bilan baham: |
