Cardiovascular responses to prolonged eccentric cycling


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Cardiovascular responses to prolonged eccentric cycling

  • Ritter O.1,2, Isacco L.3, Tordi N.1,4, Degano B.5, Bouhaddi M.5, Rakobowchuk M.6 & Mourot L.4,6
  • 1 EA 4267 FDE, Plateforme EPSI, Université de Franche-Comté
  • 2 Centre de Réadaptation Cardiologique et Pneumologique de Franche-Comté (CRCP-FC)
  • 3 EA 4660 C3S, Plateforme EPSI, Université de Franche-Comté
  • 4 Inserm CIC-CIT 808, CHRU de Besançon, France
  • 5 EA 3920 “Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires”, UFR SMP, Université de Franche-Comté
  • 6 Collège de la Santé et des Sciences de la Vie, Université de Brunel, Londres, Royaume-Uni
  • EA 4267 FDE
  • Fonctions et dysfonctions épithéliales
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • ECC contraction
  • CONC contraction
  • Lower cardio-respiratory sollicitations
  • Higher mechanical power
  • ECC compared with CONC
  • Matched for Power
  • V’O2
  • (Isner-Horobeti et al., 2013), (Melo et al., 2008), (Barnes, Trombold, Dhindsa, Lin, & Tanaka, 2010)
  • Inflammation
  • Endothelial function impairment
  • Impaired ANS activity
  • 2
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • OBJECTIVES
  • Litterature: only short CONC and ECC bouts 5 to 10 minutes (Dufour et al., 2007) / resistance training
  • Compare acute effects of prolonged aerobic (45min) CONC and ECC cycling:
  • Matched with a similar cardiac sollicitation : HR (easy + rehabilitation)
  • On cardiovascular system
  • On Autonomic Nervous System (ANS) balance
  • On endothelial function
  • 3
  • MCET
  • ECC cycling
  • CONC cycling
  • n=10
  • n=5
  • n=5
  • CONC cycling
  • ECC cycling
  • randomization
  • 45’
  • 1 month
  • 45’
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • PROTOCOL
  • MEASURES
  • HR, SAP and DAP, CO, SV, V’O2, baroreflex
  • Rest
  • Warming
  • Exercise
  • 0’
  • 5’
  • 45’
  • Baseline
  • Target
  • Matching HR
  • 45’ rec
  • Recovery
  • Endothelial function
  • 4
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • PARTICIPANTS (n = 10 males, 30±6 years, BMI 23±3 kg.m-2)
  • V̇O2 (L.min-1)
  • SAP (mmHg)
  • DAP (mmHg)
  • CO (L.min-1)
  • CON
  • ECC
  • CON
  • ECC
  • CON
  • ECC
  • CON
  • ECC
  • Base
  • 0.32 ± 0.10
  • 0.30 ± 0.04
  • 111 ± 12
  • 106 ± 11
  • 56 ± 6
  • 52 ± 7
  • 7.5 ± 1.1
  • 7.7 ± 0.9
  • Target
  • 1.21 ± 0.16 *
  • 0.92 ± 0.23
  • 149 ± 21
  • 156 ± 11
  • 74 ± 7
  • *
  • 85 ± 8
  • 12.9 ± 1.6
  • 12.4 ± 2.0
  • 15'
  • 1.30 ± 0.24
  • 1.28 ± 0.55
  • 146 ± 22
  • 150 ± 14
  • 71 ± 10
  • *
  • 81 ± 9
  • 13.9 ± 1.4
  • 14.1 ± 2.9
  • 30'
  • 1.33 ± 0.21
  • 1.26 ± 0.30
  • 141 ± 16
  • 144 ± 18
  • 67 ± 8
  • *
  • 77 ± 9
  • 14.3 ± 1.6
  • 13.9 ± 2.0
  • 45'
  • 1.32 ± 0.21
  • 1.21 ± 0.28
  • 136 ± 16
  • 143 ± 14
  • 65 ± 8
  • *
  • 77 ± 9
  • 14.0 ± 1.6
  • 14.3 ± 2.6
  • Mean power performed → CONC: 82 ± 16 W ; 97 ± 9 bpm
  • → ECC: 210 ± 40 W ; 100 ± 10 bpm
  • GENERAL RESPONSES TO EXERCISE
  • * significant difference between CON and ECC
  • repeated measures ANOVA
  • 5
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • HR AND SV EVOLUTION DURING EXERCISE
  • CONC
  • ECC
  • HR
  • SV
  • 6
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • ANS RESPONSES DURING EXERCISE: BAROREFLEX (SEQUENCE METHOD)
  • N of sequences
  • Slope
  • CONC
  • ECC
  • 7
  • * significant difference from CON
  • † significant difference from Target
  • repeated measures ANOVA
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • ENDOTHELIAL FUNCTION AFTER EXERCISE
  • Flow mediated dilation (FMD) of brachial artery
  • CONC: no differences from Baseline
  • ECC: attenuated flow mediated dilation (FMD) 45’ after exercise cessation → endothelial dysfunction
  • 8
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • During ECC (vs CONC matched with HR at exercise onset):
  • = V’O2 and = CO, but ↑ DAP, ↓ SV and ↑ HR
  • ≠ Dufour et al. (2007): higher CO, SV and HR during a 6-min ECC than CONC cycling (matched with V’O2)
  • ↓ N of baroreflex sequences
  • After ECC
  • ↓ FMD
  • FINDINGS
  • 9
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • HYPOTHESES
  • impeded rib cage expansion → intra-thoracic overpressure
  • limit SV increase
  • Lechauve et al. (2014)
  • ECC: greater muscle mass involvement (biceps brachii EMG)
  • Endothelial dysfunction
  • Inflammation (higher muscle tension)
  • Higher sympathetic activity
  • 10
  • Muscle mechanoreflex (Dufour et al. 2007)
  • Lower baroreflex
  • Greater peripheral resistances
  • Superior DAP and lower SV increase
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • During ECC (after 10 min):
  • Impeded SV so higher HR to maintain CO
  • Increased peripheral resistances → greater DAP
  • Baroreflex impairment → ANS imbalance
  • Macrovascular endothelial dysfunction
  • Study long-term (chronic) effects of ECC cycling → rehabilitation
  • CONCLUSION AND PERSPECTIVES
  • Increased constraints on cardiovascular system
  • Acute adverse effects
  • 11

Cardiovascular responses to prolonged eccentric cycling

  • Ritter O.1,2, Isacco L.3, Tordi N.1,4, Degano B.5, Bouhaddi M.5, Rakobowchuk M.6 & Mourot L.4,6
  • 1 EA 4267 FDE, Plateforme EPSI, Université de Franche-Comté
  • 2 Centre de Réadaptation Cardiologique et Pneumologique de Franche-Comté (CRCP-FC)
  • 3 EA 4660 C3S, Plateforme EPSI, Université de Franche-Comté
  • 4 Inserm CIC-CIT 808, CHRU de Besançon, France
  • 5 EA 3920 “Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires”, UFR SMP, Université de Franche-Comté
  • 6 Collège de la Santé et des Sciences de la Vie, Université de Brunel, Londres, Royaume-Uni
  • Introduction
  • Methods
  • Results
  • Discussion
  • Conclusion
  • PARTICIPANTS (n = 10 males)
  • Mean ± SD
  • Range
  • Age (y)
  • 29.6
  • ±
  • 6.4
  • 20-37
  • Weight (kg)
  • 73.3
  • ±
  • 7.7
  • 67-100
  • Height (cm)
  • 177.9
  • ±
  • 6.8
  • 165-189
  • BMI (kg.m-2)
  • 23.2
  • ±
  • 2.6
  • 20.4-29.0
  • Pmax (watt)
  • 305.6
  • ±
  • 63.1
  • 218-395
  • V’O2max (mL. kg-1.min-1)
  • 49.6
  • ±
  • 8.8
  • 36.5-61.8
  • RQmax
  • 1.16
  • ±
  • 0.04
  • 1.07-1.21



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