Comparative study on the effect of extraction solvent on total phenol, flavonoid content, antioxidant and antimicrobial properties of red onion (Allium cepa)

of diagnostic microbiology, 3rd edn., ed. by C.R. Mahon, D.C. 
Lehman, G. Manuselis (Saunders Elsevier, China, 2007)
23. S.A.S. Institute, Statistical analysis system: user’s guide statistics 
(SAS Institute Inc, Cary, NC, 2018)
24. Q.D. Do, A.E. Angkawijaya, P.L. Tran-Nguyen, L.H. Huynh, F.E. 
Soetaredjo, S. Ismadji, Y.H. Ju, Effect of extraction solvent on 
total phenol content, total flavonoid content, and antioxidant activ-
ity of Limnophilaaromatica. J. Food Drug Anal. 22(3), 296–302 
(2014)
25. M. Skerget, L. Majhenic, M. Bezjak, Z. Knez, Antioxidant, radical 
scavenging and antimicrobial activities of red onion (Allium cepa 
L) skin and edible part extracts. Chem. Biochem. Eng. Q. 23(4), 
435–444 (2009)
26. A. Lisanti, V. Formica, F. Ianni, B. Albertini, M. Marinozzi, R. 
Sardella, B. Natalini, Antioxidant activity of phenolic extracts 
from different cultivars of Italian onion (Allium cepa) and relative 
human immune cell proliferative induction. Pharm. Biol. 54(5), 
799–806 (2016)
27. G.H. Davarinejad, S.F. Taghizadeh, J. Asili, Effect of different sol-
vents on total phenolic content and antioxidant activity of Ziziphus 
jujube Miller. J. Hortic. Sci. 31(1), 158–166 (2017)
28. C. Galanakis, V. Goulas, S. Tsakona, G. Manganaris, V. Gekas, A 
knowledge base for the recovery of natural phenols with different 
solvents. Int. J. Food Prop. 16(2), 382–396 (2013)
29. S. Kamboj, V. Rana, Physicochemical, rheological and antioxidant 
potential of corn fiber gum. Food Hydrocoll. 39, 1–9 (2014)
30. A. Narkhede, S. Jagtap, Screening of Amarkand species with 
respect to their polyphenolic content and free radical quenching 
potential. Int. J. Pharm. Boisci. 6(1), 1122–1133 (2015)
31. S.A. Adebayo, M. Ondua, L.J. Shai, S.L. Lebelo, Inhibition of 
nitric oxide production and free radical scavenging activities of 
four South African medicinal plants. J. Inflamm. Res. 12, 195–203 
(2019)
32. M. Salehi, F. Saleempour, M. Navidighahroodi, Study of antibac-
terial effect of ethanol extract of Allium akaka. Iran. J. Biol. Sci. 
9, 63–68 (2011)
33. C. Nelson, A. Reginald, N. Okoro, K. Janet, Antibacterial activity 
of Allium cepa (onions) and Zingiberofficinale (ginger) on Staphy-
lococcus aureus and Pseudomonas aeruginosa isolated from high 
vaginal swab. Int. J. Trop. Med. 3, 1–6 (2007)
34. S. Hafez Quran, H. Mighani, P. Ebrahimi, In-Vitro anti-bacterial 
activity of chloroform, ethyl acetate and hydroalcoholic extracts of 
Scillapersica Hausskn. J. Gorgan Univ. Med. Sci. 16(1), 106–113 
(2014)
35. A.H. Delcour, Outer membrane permeability and antibiotic resist-
ance. Biochim. Biophys. Acta 1794, 808–816 (2009)
36. H. Nikaido, Molecular basis of bacterial outer membrane perme-
ability revisited. Microbiol. Mol. Biol. Rev. 67, 593–656 (2003)
37. A.F. Abdel-Salam, M.E. Shahenda, B.A. Jehan, Antimicrobial and 
antioxidant activities of red onion, garlic and leek in sausage. Afr. 
J. Microbiol. Res. 8(27), 2574–2582 (2014)
38. M. Mazandarani, A. Momeji, P. Zarghami Moghaddam, Evalu-
ation of phytochemical and antioxidant activities from different