2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry

Figure captions
Chart 1. Structures of reference compounds that were compared with 2-ATs in anticancer studies
Fig. 1. Four versions of the Gewald reaction
Fig. 2. Some neurologically relevant 2-AT-related drugs and drug candidates
Fig. 3. The ratio of patented ATs for the years 1939-2000 and 2001-2017
Fig. 4. Structures of potential anticancer compounds 5-8
Fig. 5. Structures of antifungal compounds 16 and 17
Fig. 6. Structures of compounds 28 and 29
Fig. 7. Structures of the A₁AR modulators (compounds 50-67)
Fig. 8. Structures of COR627 and COR628
Fig. 9. Structures of potential compounds 86-88
Fig. 10. Structure of compound 94
Fig. 11. Structures of compounds 97-99
Fig. 12. Structures of compounds 100 and 101
Scheme 1. Structures and formation of the potential antiproliferative compounds 1 and 2
Scheme 2. Structure and synthetic pathway of the potential antimitotic agent 3
Scheme 3. Structure and synthetic pathway of the potential antitumor compound 4
Scheme 4. Structures and synthetic pathways of potential compounds 9-12
Scheme 5. Structures and formation of antimicrobial compounds 13 and 14 via Gewald cyclization
Scheme 6. Structure and synthetic route of antimicrobial compound 15
Scheme 7. Structures, synthetic methods and conditions for antimicrobial compounds 18, 19 and structure of compound 20
Scheme 8. Structures and synthetic pathways of anti-influenza agents 21 and 22
Scheme 9. Structures and synthesis of potential anti-tubercular compounds 23-26
Scheme 10. Structure and formation of potential compound 27