"Frontmatter". In: Plant Genomics and Proteomics
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Christopher A. Cullis - Plant Genomics and Proteomics-J. Wiley & Sons (2004)
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UMMARY Gene discovery involves a number of different phases, some of which can be carried out in parallel. Most of the discovery starts at the sequence level, either with genomic sequence or ESTs. The informatics analyses applied to the sequence data lead to tentative gene assignments. The confirmation of the function of these tentative expressed sequences (from genomic DNA) or actual expressed sequences is dependent on additional data. These data can come from comparative analyses with other organisms where the function of a similar sequence is known or from direct protein functional studies. Patterns of gene expression can also give indications of possible function. However, at present, it is not possible to go directly from nucleic acid sequence to protein function, and therefore gene identity, in any organism. R EFERENCES Azpiroz-Leehan, R ,and K. A. Feldmann (1997) T-DNA insertion mutagenesis in Arabidopsis: going back and forth. Trends Genet. 13, 152–156. R EFERENCES 8 7 Chory, J., J. R. Ecker, S. Briggs, M. Caboche, G. M. Coruzzi, D. Cook, J. Dangl, S. Grant, M. L. Guerinot, S. Henikoff, R. Martienssen, K. Okada, N. V. Raikhel, C. R. Somerville. and D. Weigel (2000) National Science Foundation-Sponsored Work- shop Report: “The 2010 Project” Functional Genomics and the Virtual Plant. A Blueprint for Understanding How Plants Are Built and How to Improve Them. Plant Physiol. 123, 423–426. Cogoni, C., and G. Macino (2000) Post-transcriptional gene silencing across king- doms. Genes Dev. 10, 638–643. Colbert, T., B. J. Till, R. Tompa, S. Reynolds, M. N. Steine, A. T. Yeung, C. M. McCallum, L. Comai, and S. Henikoff (2001) High-throughput screening for induced point mutations. Plant Physiol. 126, 480–484. McCallum, C. M., L. Comai, E. A. Greene, and S. Henikoff (2000) Targeting Induced Local Lesions In Genomes (TILLING) for plant functional genomics. Plant Physiol. 123, 439–442. Oleykowski C. A., C. R. Bronson Mullins, A. K. Godwin, and A. T. Yeung (1998) Muta- tion detection using a novel plant endonuclease Nucleic Acids Res. 26, 4597–4602. Parinov, S., and V. Sundaresan (2000) Functional genomics in Arabidopsis: Large scale insertional mutagenesis complements the genome sequencing project. Curr. Opin. Biotechnol. 11, 157–161. Ramachandran, S., and V. Sundaresan (2001) Transposons as tools for functional genomics. Plant Physiol. Biochem. 39, 243–252. Tang G. L., B. J. Reinhart, D. P. Bartel, and P. D. Zamore (2003) A biochemical frame- work for RNA silencing in plants. Genes Dev. 17, 49–63. The Arabidopsis Genome Initiative (2000) Analysis of the genome sequence of the flowering plant, Arabidopsis thaliana. Nature 408, 796–815. Wang, E., R. Wang, J. DeParasis, J. H. Loughrin, S. Gan, and G. J. Wagner (2001) Suppression of a P450 hydroxylase gene in plant trichome glands enhances natural-product-based aphid resistance Nature Biotechnol. 19, 371–374. Walbot, V. (2000) Saturation mutagenesis using maize transposons. Curr. Opin. Plant Biol. 3, 103–107. Ware, D., P. Jaiswal, J. Ni, X. Pan, K. Chang, K. Clark, T. L. Clark, S. Schmidt, W. Zhao, S. Cartinhour, S. McCouch, and L. Stein (2002) Gramene: a resource for com- parative grass. Genomics Nucleic Acids Res. 30, 103–105. 8 8 4. G E N E D I S C O V E R Y |
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