Medical advisory board member


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Medical advisory board member

  • Medical advisory board member

  • Grant/Research Support



Incomplete revascularization (ICR) is common, present in 17-85% of patients following PCI

  • Incomplete revascularization (ICR) is common, present in 17-85% of patients following PCI

  • ICR has been strongly associated with increased rates of repeat hospitalization, repeat revascularization, and mortality

  • Ranolazine is a late Na+ current blocker that reduces ischemia







To evaluate the efficacy of ranolazine as compared with placebo when used as part of standard medical therapy in patients who had chronic angina and with incomplete revascularization post-PCI

    • To evaluate the efficacy of ranolazine as compared with placebo when used as part of standard medical therapy in patients who had chronic angina and with incomplete revascularization post-PCI






Future planned revascularization

    • Future planned revascularization
    • Unprotected LM ≥50% diameter stenosis
    • Major complications during the index PCI
    • NYHA Class III-IV CHF
    • Stroke within 90 days or major disability
    • eGFR <30 mL/min/1.73m2
    • Cirrhosis
    • Previous ranolazine use for >7d within 30d
    • Hypersensitivity or intolerance to ranolazine
    • Use of class Ia, Ic, or class III antiarrhythmic (except amiodarone)
    • Strong CYP3A inhibitors, CYP3A4 or P-gp inducers
    • >20 mg simvastatin daily, >40 mg lovastatin daily, or >1000 mg metformin daily


Primary Endpoint:

  • Primary Endpoint:

    • The time from randomization to the first occurrence of either:
    • Ischemia-driven revascularization
    • Ischemia-driven hospitalization
  • Secondary Endpoints:

    • Time from randomization to sudden cardiac death
    • Time from randomization to CV death
    • Time from randomization to MI


Safety Endpoints

  • Safety Endpoints

    • All case mortality
    • Stroke
    • Transient ischemic attack (TIA)
    • MACE (composite of CV death, MI, stroke)
    • Hospitalization for heart failure


Event-driven with accrual of ~720 primary endpoints

  • Event-driven with accrual of ~720 primary endpoints

  • Assuming 20% event rate in the placebo group, conservatively based on the MERLIN sub-analysis

  • Follow-up of at least 1 year

  • 20% risk reduction with ranolazine

  • 2600 pts → 85% power at a 2-sided α=0.05



Principal Investigator

  • Principal Investigator

    • Giora Weisz, MD
    • Shaare Zedek Medical Center
    • Columbia University Medical Center
  • Study Chairman

    • Gregg W. Stone, MD
    • Columbia University Medical
  • Executive Committee

  • Giora Weisz, MD, Gregg W. Stone, MD, Karen Alexander, MD; Bernard DeBruyne, MD, PhD; Amir Lerman, MD; Ehtisham Mahmud, MD; Gilles Montalescot, MD, PhD; Magnus Ohman, MD; Harvey White, MD.

  • Data Management and Biostatistics

    • Ori Ben-Yehuda, MD, Ovidiu Dressler, MD, Ray Hang Zhong, Melissa Nichols MSc Cardiovascular Research Foundation


Austria (total enrolment = 28): Steinwender Clemens, Allgemeines Krankenhaus der Stadt Linz, Linz. Friedrich Guy, Innsbruck Universitaetsklinik, Innsbruck. Mortl Deddo, Landesklinikum Sankt Pölten, Saint Pölten. Schuchlenz Herwig, Landeskrankenhaus Graz West, Graz. Kastner Johannes, Medizinische Universität Wien, Wien. Huber Kurt, Wilhelminenspital der Stadt Wien, Wien. Belgium (total enrolment = 43): Muyldermans Luc, Algemeen Ziekenhuis Sint-Jan, Brugge. Legrand Victor, Centre Hospitalier Universitaire Sart Tilman Liège, Liège. Roosen John, Imelda Ziekenhuis, Bonheiden. Verheye Stefan, Ziekenhuis Netwerk Antwerpen Middelheim, Antwerpen. Vrolix Mathias, ZOL Genk, Campus Saint Jan, Genk. Canada (total enrolment = 166): Kokis André, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Canada. Nguyen Miche, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada. Mehta Shamir, Hamilton Health Sciences, General Site, Hamilton, Canada. Schampaert Erick, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada. Rodés-Cabau Josep, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Canada. Jolicoeur Marc, Montreal Heart Institute, Montreal, Canada. Hubacek Jaroslav, New Brunswick Heart Centre, Saint John, Canada. Dorsch Michael, Royal Alexandra Hospital, Edmonton, Canada. Buller Christopher, Saint Michael's Hospital, Toronto, Canada. Mukherjee Ashok, Scarborough Cardiology Research Associates, Scarborough, Canada. Dzavik Vladimir, University Health Network, Toronto, Canada. Welsh Robert, University of Alberta Hospital, Edmonton, Canada. Czech Republic (total enrolment = 75): Kala Petr, Fakultní nemocnice Brno, Brno. Budesinsky Tomas, Fakultní nemocnice Královské Vinohrady, Praha 10. Skvarilová Marcela, Fakultní nemocnice Olomouc, Olomouc. Groch Ladislav, Fakultní nemocnice u sv. Anny v Brne, Brn. Zemanek David, Fakultní Nemocnice v Motole, Praha 5. Ondrejcak Roman, Karlovarská krajská nemocnice a.s., Karlovarská krajská nemocnice a.s., Horak David, Krajská nemocnice Liberec a.s., Liberec. Horak Jan, Všeobecná fakultní nemocnice v Praze, Prague 2. France (total enrolment = 37): Belle Loic, Centre Hospitalier d'Annecy, Pringy. Hannebicque Gery, Centre Hospitalier d'Arras, Arras. Montalescot Gilles, Groupe hospitalier La Pi tié Salpêtrière, Paris Cedex 13. Steg Philippe Gabriel, Hôspital Bichat-Claude Bernard, Paris. Carrie Didier, Hôpital Rangueil, Toulouse Cedex 9. Germany (total enrolment = 64): Olbrich Hans-Georg, Asklepios-Kliniken Langen, Langen. Moellmann Helge, Kerckhoff-Klinik GmbH, Bad Nauheim. vom Dahl, Jurgen, Kliniken Maria Hilf GmbH, Mönchengladbach. Hauptmann Karl Eugen, Krankenhaus der Barmherzigen Brüder, Trier. Schulze-Waltrup Norbert, Sankt Johannes Hospital, Dortmund. Stellbrink Christoph, Städtische Kliniken Bielefeld GmbH, Bielefeld. Licka Manuela, Universitätsklinikum Heidelberg, Heidelberg. Ince Huseyin, Vivantes Klinikum im Friedrichshain, Berlin. Israel (total enrolment = 223): Vered Zvi, Assaf Harofeh Medical Centre, Zerifin. Katz Amos, Barzilai Medical Center, Ashkelon. Rosenschein Uri, Bnei Zion Medical Center, Haifa. Rozenman Yoseph, Edith Wolfson Medical Center, Holon. Danenberg Haim, Hadassah Medical Center, Jerusalem. Turgeman Yoav, HaEmek Medical Center, Afula. Frimerman Aaron, Hillel Yaffe Medical Center, Hadera. Shimoni Sara, Kaplan Medical Center, Rechovot. Mosseri Morris, Meir Medical Center, Kfar Saba. Nikolsky Eugenia, Rambam Medical Center, Haifa. Klutstein Marc, Shaare Zedek Medical Center, Jerusalem. Shechter, Michael, The Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan. Banai Shmuel, Tel Aviv Souraski Medical Center, Tel Aviv. Atar Shaul, Western Galilee Hospital-Nahariya, Nahariya. Halabi Majdi, Ziv Medical Center, Zefat. Italy (total enrolment = 61): Stabile Amerigo, A.R.N.A.S. Civico G. Di Cristina Benfratelli, Palermo. Musumeci Giuseppe, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo. Mascia Franco, Azienda Ospedaliera S. Sebastiano di Caserta, Caserta. De Luca Giuseppe, Azienda Ospedaliero Universitaria "Maggiore della Carita" di Novara, Novara. Menozzi Alberto, Azienda Ospedaliero Universitaria di Parma, Parma. Antoniucci David, Azienda Ospedaliero-Universitaria Careggi, Firenze. Brunelli Claudio, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova. Terrosu Pierfranco, Ospedale Civile SS Annunziata ASL 1, Sassari. Colombo Antonio, Ospedale San Raffaele-IRCCS, Milano Netherlands (total enrolment = 26): Henriques José, Academisch Medisch Centrum, Amsterdam. Koolen Jacques, Catharina Ziekenhuis, Eindhoven. Smits Pieter, Maasstad Ziekenhuis, Rotterdam. Winkens Mark, TweeSteden Ziekenhuis, Tilburg. Danse Peter, Ziekenhuis Rijnstate Arnhem, Arnhem. Poland (total enrolment = 378): Ponikowski Piotr, 4th Wojskowy Szpital Kliniczny z Poliklinika, Klinika Kardiologii, Wrocław. Buszman Pawel, American Heart of Poland S.A., Ustroń. Gorycki Bogdan, American Heart of Poland S.A., Bielsko-Biała. Kondys, Marek, American Heart of Poland S.A., Dąbrowa Górnicza. Pruski Maciej, American Heart of Poland S.A. Tychy. Mlodziankowski Adam, American Heart of Poland S.A., Mielec. Prokopczuk, Janusz, American Heart of Poland S.A., Kędzierzyn Koźle. Kosmider Maciej, American Heart of Poland S.A., Bełchatów. Zurakowski Aleksander, American Heart of Poland S.A., Chrzanów. Gil Robert, Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie, Warszawa. Witkowski Adam, Instytut Kardiologii, Warszawa. Lesiak Maciej, Samodzielny Publiczny Szpital Kliniczny nr. 1 im. Przemienienia Panskiego, Poznań. Opolski Grzegorz, Samodzielny Publiczny Centralny Szpital Kliniczny w Warszawie, Warszawa. Wojakowski Wojciech, Slaskiego Uniwersytetu Medycznego w Katowicach, Górnoslaskie Centrum Medyczne, Katowice. Wujkowski Marek, Szpital Wojewódzki we Wloclawku, Włocławek. Dudek Dariusz, Uniwersytecki Szpital Dzieciecy w Krakowie, Kraków. Jaworska Krystyna, Wojewodzki Szpital Zespolony, Toruń. Russia (total enrolment = 323): Andreev Denis University Clinical Hospital #1, Moscow. Baranov Evgeny, City Clinical Hospital #5, Nizhni Novgorod. Barbarash Olga, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo. Belenky Dmitry, City clinical emergency hospital # 2, Novosibirsk. Duda Alexey, Altai Regional Cardiological Dispensary, Barnaul. Eltishcheva Vera, Medical Center “Alliance”,Kirovsk. Gordeev Ivan, City Clinical Hospital #15 named after O.M. Filatov, Moscow. Ivanenko Vitaly, Volgograd Regional Clinical Cardiological Center, Volgograd. Kalinina Svetlana, Ural Institute of Cardiology, Ekaterinburg. Kamalov Gadel, Republic Clinical Hospital № 2, Kazan. Karpenko Mikhail, Federal center of heart, blood and endocrinology n.a. V.A.Almazov, Sain-Petersburg. Libov Igor, City Clinical Hospital n.a. S.P.Botkin, Moscow. Linev Kirill, Regional Clinical Hospital, Krasnoyarsk. Markov Valentin, Scientific and Research Institution Of Cardiology, Tomsk. Mazaev Vladimir, National Research Center For Preventive Medicine, Moscow. Oleynikov Valentin, Penza Regional Clinical Hospital n.a. N.N. Burdenko, Penza. Privalova Elena, University Clinical Hospital #1, Moscow. Shutemova Elena, Cardiological Dispensary, Ivanovo. Sokolova Nadejda, Regional Clinical Hospital №3, Chelyabinsk. Vasilieva Elena, City Clinical Hospital # 23 n.a.“Medsantrud”, Moscow.Spain (total enrolment = 174): Moris Cesar, Hospital Central de Asturias, Oviedo. Martin Yuste Victoria, Hospital Clinic I Provincial de Barcelona, Barcelona. Sanchis Juan, Hospital Clinico Universitario de Valencia, Valencia. Hernández José-María, Hospital Clínico Universitario Virgen de la Victoria, Málaga. Iñiguez Andres, Hospital de Meixoeiro, Vigo. Mainar Vicente, Hospital General Universitario de Alicante, Alicante. Nunez Ivan, Hospital San Carlos Madrid, Madrid. Cequier Fillat Ángel Ramon, Hospital Universitario de Bellvitge, L´Hospitalet de Llobregat. Moreno Raul, Hospital Universitario La Paz, Madrid. Zueco Javier, Hospital Universitario Marques de Valdecilla, Santander. Garcia Bruno, Hospital Vall d´Hebrón, Barcelona.Sweden (total enrolment = 44): Hagström Lars, Falu lasarett, Falun. Carlsson, Roland, Karlstad Central Hospital, Karlstad. Omerovic Elmir, Sahlgrenska Universitetsjukhuset, Göteborg. Kellerth Thomas, Mölnlycke. Universitetssjukhuset Örebro, Mölnlycke. James Stefan, Uppsala University Hospital, Uppsala.United Kingdom (total enrolment = 33): Fluck David, Ashford and Saint Peter's Hospital NHS Trust, Surrey. Zaman Azfar, Freeman Hospital, Newcastle upon Tyne. Hildick-Smith David, Royal Sussex County Hospital, Brighton. Spence Mark, Royal Victoria Hospital, Belfast. Wong Yuk-Ki, Saint Richards Hospital, West Sussex. De Belder Mark, The James Cook University Hospital, Middlesbrough.United States (total enrolment = 976): Abbott J. Dawn, Rhode Island Hospital, Providence, RI. Abu-Fadel Mazen, Oklahoma City Veterans' Affairs Medical Center, Oklahoma City, OK. Albirini Abdulah, Cardiology Associates of Southeast Ohio, Inc., Zanesville, OH. Al-Joundi Bassam, Gateway Cardiology, PC, Saint Louis, MO. Anderson R. David, University of Florida, Gainesville, FL. Angiolillo Dominick, University of Florida Health Sciences Center-Jacksonville, Jacksonville, FL. Applegate Robert, Wake Forest University School of Medicine, Winston-Salem, NC. Assi Nizar, Gateway Cardiology, PC, Saint Louis, MO. Atanasoski-McCormack Violet, Broward General Medical Center, Fort Lauderdale, FL. Atassi Keith, Northwest Indiana Cardiovascular Physicians, Valparaiso, IN. Banerjee Subhash, North Texas Healthcare System, Dept. of Veteran's Affairs, Dallas, TX. Bansal Manish, Baptist Heart Specialists, Jacksonville Beach, FL. Bansal Sharad, Mercy Medical Research Institute, Springfield, MO. Barsness Gregory, Mayo Clinic, Rochester, MN. Batchelor Wayne, Tallahassee Research Institute, Tallahassee, FL. Bavry Anthony, North Florida/South Georgia Veterans Health System, Gainsville, FL. Beohar Nirat, Mount Sinai Medical Center, Miami Beach, FL. Bertolet Barry, Cardiology Associates of North Mississippi, Tupelo, MS. Blankenship James, Geisinger Medical Center, Danville, PA. Bouchard Alain, Cardiology, PC, Birmingham, AL. Brener Sorin, New York Methodist Hospital, Brooklyn, NY. Brott Brigitta, University of Alabama at Birmingham, Birmingham, AL. Caputo Ronald, SJH Cardiology Associates, Liverpool, NY. Carrozza Jr. Joseph, Saint Elizabeth's Medical Center, Boston, MA. Chandna Harish, Victoria Heart and Vascular Center, Victoria, TX. Cohen Martin, Westchester Medical Center, Valhalla, NY. Daniel Kurt, Carolina Cardiology Associates, High Point, NC. Dauber Ira, South Denver Cardiology Associates, PC, Littleton, CO. Davis Scott, Arkansas Cardiology, Little Rock, AR. Devries James, Dartmouth Hitchcock Medical Center, Lebanon, NH. D'Urso Michael, Black Hills Cardiovascular Cardiology Associates P.C., Rapid City, SD. Ellis Stephen, The Cleveland Clinic Foundation, Cleveland, OH. Erickson Bernard, Saint Cloud Hospital,, Saint Cloud, MN. Flores Angel, The Heart and Vascular Center, Beaver, PA. Garas Samer, Saint Vincent's Ambulatory Care, Jacksonville, FL. Gershony Gary, John Muir Medical Center Concord Campus, Concord, CA. Ghali Magdi, Iowa Heart Center, West Des Moines, IA. Ginete Wilson, Essential Health, Duluth, MN. Gogo Jr. Prospero, University of Vermont Medical Center, Fletcher Allen Health Care, Burlington, VT. Gruberg Luis, Stony Brook University Medical Center, Stony Brook, NY. Guidera Steven, Central Bucks Cardiology, Doylestown, PA. Gumina Richard, The Ohio State University Wexner Medical Center, Columbus, OH. Gurbel Paul, Baltimore Heart Associates, Baltimore, MD. Hahn Harvey, Southwest Cardiology, Inc, Kettering, OH. Hahn Richard, The Indiana Heart Hospital, Indianapolis, IN. Hamroff Glenn, Hudson Valley Cardiology Group, PC, Cortlandt Manor, NY. Henderson David, Cardiology Research Associates, Daytona Beach, FL. Iwaoka Robert, Novant Health Heart and Vascular Institute, Charlotte, NC. Izzo Mark, Saint Vincent Health Care Center, Erie, PA. Jafar M. Zubair, Hudson Valley Heart Center, Poughkeepsie, NY. Jayasuriya Sasanka, The University of Arizona, Tucson, AZ. Jenkins J. Stephen, Ochsner Clinic Foundation, New Orleans, LA. Jobe Robert, Wake Heart Research, Raleigh, NC. Jones William, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC. Kaluski Edo, University Medical and Denistry of New Jersey, Newark, NJ. Kander Nathan, Ohio Health Research Institute, Columbus, OH. Kelberman Michael, Central New York Cardiology, Utica, NY. Kiesz Radoslaw, San Antonio Endovascular and Heart Institute, San Antonio, TX. Kim Christopher, Utah Cardiology, PC, Layton, UT. Klag Joseph, Scottsdale Healthcare, Scottsdale, AZ. Krawczyk Justine, Buffalo Cardiology and Pulmonary Associates, PC, Williamsville, NY. Lane Gary, Mayo Clinic Jacksonville, Jacksonville, FL. Langevin Eugene, Freeman West Hospital, Joplin, MO. Lansky Alexandra, Yale University, New Haven, CT. Londono Juan, Future Care Solution, LLC, Hialeah, FL. Lui Henry, Research Associates of Jackson, Jackson, TN. Mahmud Ehtisham, University of California, San Diego, La Jolla, CA. Maini Brijeshwar, Pinnacle Health System, Wormleysburg, PA. Marques Vasco, Pepin Heart Hospital and Dr. Kiran C. Patel Research Institute, Tampa, FL. Martinelli Michael, Albany Associates in Cardiology, Albany, NY. Masud A.R. Zaki, Buffalo Heart Group, Buffalo, NY. McLaurin Brent, AnMed Health, Anderson, SC. Moreno Pedro, Mount Sinai Medical Center, New York, NY. Mulkay Angel, Holy Name Medical Center, Teaneck, NJ. Munuswamy, Karan, Holy Cross Hospital, Fort Lauderdale, FL. Nathan Sandeep, University of Chicago Medical Center, Chicago, IL. Nolan Brian, Saint Luke's Clinic - Idaho Cardiology Associates, Boise, ID. Oswood Bradley, Scottsdale Healthcare, Scottsdale, AZ. Parikh Manish, Columbia University Medical Center, New York, NY. Patel Samir, Cardiovascular Institute of Northwest Florida, Panama City, FL. Pattanayak Jan, Asheville Cardiology Associates, Asheville, NC. Penny William, Veterans Affairs San Diego Healthcare System, San Diego, CA. Petersen John, Swedish Medical Center, Seattle, WA. Ponce George, Spectrum Clinical Research Institute, Inc, Moreno Valley, CA. Portnay Edwardmart, Cardiology Associates of Fairfield County, PC, Stamford, CT. Quintana Ofsman, Valley Central Research, Inc., Mission, TX. Qureshi Mansoor, Michigan Heart, PC, Ypsilanti, MI. Rabah Maher, William Beaumont Hospital, Royal Oak, MI. Rahman, Aref, Veterans Administration Medical Center, Pittsburgh, PA. Revana Madaiah, Humble Cardiology Associates, Humble, TX. Riba Arthur, Oakwood Hospital and Medical Center, Dearborn, MI. Riddick John, Centennial Heart Cardiovascular Consultants, LLC, Nashville, TN. Rouch Carl, Indiana Heart Physicians, Inc., Indianapolis, IN. Rozeman Phillip, Clinical Trials of America, Inc., Minden, LA. Scott, J. Christopher, University of Tennessee, Knoxville, TN. Seals Albert, East Coast Institute for Research, Jacksonville, FL. Seifein Hani, Florida Heart Institute, Orlando, FL. Sharma Mukesh, Parkway Cardiology Associates, Oak Ridge, TN. Shunk Kendrick, San Francisco Veterans Affairs Medical Center, San Francisco, CA. Stine Ronald, Sentara Cardiovascular Research Institute, Norfolk, VA. Tahirkheli Naeem, South Oklahoma Heart Research, Oklahoma City, OK. Talreja Deepak, Cardiovascular Associates, Ltd., Virginia Beach, VA. Teirstein Paul, Scripps Health, La Jolla, CA. Traverse Jay, Minneapolis Heart Institute, Minneapolis, MN. Vasquez Alejandro, Heart Center Research, LLC, Huntsville, AL. Waksman Ron, Washington Hospital Center, Washington, DC. Waltman Jonathan, Saint Joseph Cardiology Associates, KY. Wang John, Union Memorial Hospital, Baltimore, MD. Weinstein Debra, Zasa Clinical Research, Atlantis, FL. Weintraub Andrew, Tufts Medical Center Neely Center for Cancer Research, Boston, MA. Wiseman Alan, Northeast Cardiology Associates, Bangor, ME. Zelman Richard, Cape Cod Research Institute, Hyannis, MA. Zhang Wenwu, Clinical Trials of America, Inc., Shreveport, LA.

  • Austria (total enrolment = 28): Steinwender Clemens, Allgemeines Krankenhaus der Stadt Linz, Linz. Friedrich Guy, Innsbruck Universitaetsklinik, Innsbruck. Mortl Deddo, Landesklinikum Sankt Pölten, Saint Pölten. Schuchlenz Herwig, Landeskrankenhaus Graz West, Graz. Kastner Johannes, Medizinische Universität Wien, Wien. Huber Kurt, Wilhelminenspital der Stadt Wien, Wien. Belgium (total enrolment = 43): Muyldermans Luc, Algemeen Ziekenhuis Sint-Jan, Brugge. Legrand Victor, Centre Hospitalier Universitaire Sart Tilman Liège, Liège. Roosen John, Imelda Ziekenhuis, Bonheiden. Verheye Stefan, Ziekenhuis Netwerk Antwerpen Middelheim, Antwerpen. Vrolix Mathias, ZOL Genk, Campus Saint Jan, Genk. Canada (total enrolment = 166): Kokis André, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Canada. Nguyen Miche, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada. Mehta Shamir, Hamilton Health Sciences, General Site, Hamilton, Canada. Schampaert Erick, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada. Rodés-Cabau Josep, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Canada. Jolicoeur Marc, Montreal Heart Institute, Montreal, Canada. Hubacek Jaroslav, New Brunswick Heart Centre, Saint John, Canada. Dorsch Michael, Royal Alexandra Hospital, Edmonton, Canada. Buller Christopher, Saint Michael's Hospital, Toronto, Canada. Mukherjee Ashok, Scarborough Cardiology Research Associates, Scarborough, Canada. Dzavik Vladimir, University Health Network, Toronto, Canada. Welsh Robert, University of Alberta Hospital, Edmonton, Canada. Czech Republic (total enrolment = 75): Kala Petr, Fakultní nemocnice Brno, Brno. Budesinsky Tomas, Fakultní nemocnice Královské Vinohrady, Praha 10. Skvarilová Marcela, Fakultní nemocnice Olomouc, Olomouc. Groch Ladislav, Fakultní nemocnice u sv. Anny v Brne, Brn. Zemanek David, Fakultní Nemocnice v Motole, Praha 5. Ondrejcak Roman, Karlovarská krajská nemocnice a.s., Karlovarská krajská nemocnice a.s., Horak David, Krajská nemocnice Liberec a.s., Liberec. Horak Jan, Všeobecná fakultní nemocnice v Praze, Prague 2. France (total enrolment = 37): Belle Loic, Centre Hospitalier d'Annecy, Pringy. Hannebicque Gery, Centre Hospitalier d'Arras, Arras. Montalescot Gilles, Groupe hospitalier La Pi tié Salpêtrière, Paris Cedex 13. Steg Philippe Gabriel, Hôspital Bichat-Claude Bernard, Paris. Carrie Didier, Hôpital Rangueil, Toulouse Cedex 9. Germany (total enrolment = 64): Olbrich Hans-Georg, Asklepios-Kliniken Langen, Langen. Moellmann Helge, Kerckhoff-Klinik GmbH, Bad Nauheim. vom Dahl, Jurgen, Kliniken Maria Hilf GmbH, Mönchengladbach. Hauptmann Karl Eugen, Krankenhaus der Barmherzigen Brüder, Trier. Schulze-Waltrup Norbert, Sankt Johannes Hospital, Dortmund. Stellbrink Christoph, Städtische Kliniken Bielefeld GmbH, Bielefeld. Licka Manuela, Universitätsklinikum Heidelberg, Heidelberg. Ince Huseyin, Vivantes Klinikum im Friedrichshain, Berlin. Israel (total enrolment = 223): Vered Zvi, Assaf Harofeh Medical Centre, Zerifin. Katz Amos, Barzilai Medical Center, Ashkelon. Rosenschein Uri, Bnei Zion Medical Center, Haifa. Rozenman Yoseph, Edith Wolfson Medical Center, Holon. Danenberg Haim, Hadassah Medical Center, Jerusalem. Turgeman Yoav, HaEmek Medical Center, Afula. Frimerman Aaron, Hillel Yaffe Medical Center, Hadera. Shimoni Sara, Kaplan Medical Center, Rechovot. Mosseri Morris, Meir Medical Center, Kfar Saba. Nikolsky Eugenia, Rambam Medical Center, Haifa. Klutstein Marc, Shaare Zedek Medical Center, Jerusalem. Shechter, Michael, The Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan. Banai Shmuel, Tel Aviv Souraski Medical Center, Tel Aviv. Atar Shaul, Western Galilee Hospital-Nahariya, Nahariya. Halabi Majdi, Ziv Medical Center, Zefat. Italy (total enrolment = 61): Stabile Amerigo, A.R.N.A.S. Civico G. Di Cristina Benfratelli, Palermo. Musumeci Giuseppe, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo. Mascia Franco, Azienda Ospedaliera S. Sebastiano di Caserta, Caserta. De Luca Giuseppe, Azienda Ospedaliero Universitaria "Maggiore della Carita" di Novara, Novara. Menozzi Alberto, Azienda Ospedaliero Universitaria di Parma, Parma. Antoniucci David, Azienda Ospedaliero-Universitaria Careggi, Firenze. Brunelli Claudio, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova. Terrosu Pierfranco, Ospedale Civile SS Annunziata ASL 1, Sassari. Colombo Antonio, Ospedale San Raffaele-IRCCS, Milano Netherlands (total enrolment = 26): Henriques José, Academisch Medisch Centrum, Amsterdam. Koolen Jacques, Catharina Ziekenhuis, Eindhoven. Smits Pieter, Maasstad Ziekenhuis, Rotterdam. Winkens Mark, TweeSteden Ziekenhuis, Tilburg. Danse Peter, Ziekenhuis Rijnstate Arnhem, Arnhem. Poland (total enrolment = 378): Ponikowski Piotr, 4th Wojskowy Szpital Kliniczny z Poliklinika, Klinika Kardiologii, Wrocław. Buszman Pawel, American Heart of Poland S.A., Ustroń. Gorycki Bogdan, American Heart of Poland S.A., Bielsko-Biała. Kondys, Marek, American Heart of Poland S.A., Dąbrowa Górnicza. Pruski Maciej, American Heart of Poland S.A. Tychy. Mlodziankowski Adam, American Heart of Poland S.A., Mielec. Prokopczuk, Janusz, American Heart of Poland S.A., Kędzierzyn Koźle. Kosmider Maciej, American Heart of Poland S.A., Bełchatów. Zurakowski Aleksander, American Heart of Poland S.A., Chrzanów. Gil Robert, Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie, Warszawa. Witkowski Adam, Instytut Kardiologii, Warszawa. Lesiak Maciej, Samodzielny Publiczny Szpital Kliniczny nr. 1 im. Przemienienia Panskiego, Poznań. Opolski Grzegorz, Samodzielny Publiczny Centralny Szpital Kliniczny w Warszawie, Warszawa. Wojakowski Wojciech, Slaskiego Uniwersytetu Medycznego w Katowicach, Górnoslaskie Centrum Medyczne, Katowice. Wujkowski Marek, Szpital Wojewódzki we Wloclawku, Włocławek. Dudek Dariusz, Uniwersytecki Szpital Dzieciecy w Krakowie, Kraków. Jaworska Krystyna, Wojewodzki Szpital Zespolony, Toruń. Russia (total enrolment = 323): Andreev Denis University Clinical Hospital #1, Moscow. Baranov Evgeny, City Clinical Hospital #5, Nizhni Novgorod. Barbarash Olga, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo. Belenky Dmitry, City clinical emergency hospital # 2, Novosibirsk. Duda Alexey, Altai Regional Cardiological Dispensary, Barnaul. Eltishcheva Vera, Medical Center “Alliance”,Kirovsk. Gordeev Ivan, City Clinical Hospital #15 named after O.M. Filatov, Moscow. Ivanenko Vitaly, Volgograd Regional Clinical Cardiological Center, Volgograd. Kalinina Svetlana, Ural Institute of Cardiology, Ekaterinburg. Kamalov Gadel, Republic Clinical Hospital № 2, Kazan. Karpenko Mikhail, Federal center of heart, blood and endocrinology n.a. V.A.Almazov, Sain-Petersburg. Libov Igor, City Clinical Hospital n.a. S.P.Botkin, Moscow. Linev Kirill, Regional Clinical Hospital, Krasnoyarsk. Markov Valentin, Scientific and Research Institution Of Cardiology, Tomsk. Mazaev Vladimir, National Research Center For Preventive Medicine, Moscow. Oleynikov Valentin, Penza Regional Clinical Hospital n.a. N.N. Burdenko, Penza. Privalova Elena, University Clinical Hospital #1, Moscow. Shutemova Elena, Cardiological Dispensary, Ivanovo. Sokolova Nadejda, Regional Clinical Hospital №3, Chelyabinsk. Vasilieva Elena, City Clinical Hospital # 23 n.a.“Medsantrud”, Moscow.Spain (total enrolment = 174): Moris Cesar, Hospital Central de Asturias, Oviedo. Martin Yuste Victoria, Hospital Clinic I Provincial de Barcelona, Barcelona. Sanchis Juan, Hospital Clinico Universitario de Valencia, Valencia. Hernández José-María, Hospital Clínico Universitario Virgen de la Victoria, Málaga. Iñiguez Andres, Hospital de Meixoeiro, Vigo. Mainar Vicente, Hospital General Universitario de Alicante, Alicante. Nunez Ivan, Hospital San Carlos Madrid, Madrid. Cequier Fillat Ángel Ramon, Hospital Universitario de Bellvitge, L´Hospitalet de Llobregat. Moreno Raul, Hospital Universitario La Paz, Madrid. Zueco Javier, Hospital Universitario Marques de Valdecilla, Santander. Garcia Bruno, Hospital Vall d´Hebrón, Barcelona.Sweden (total enrolment = 44): Hagström Lars, Falu lasarett, Falun. Carlsson, Roland, Karlstad Central Hospital, Karlstad. Omerovic Elmir, Sahlgrenska Universitetsjukhuset, Göteborg. Kellerth Thomas, Mölnlycke. Universitetssjukhuset Örebro, Mölnlycke. James Stefan, Uppsala University Hospital, Uppsala.United Kingdom (total enrolment = 33): Fluck David, Ashford and Saint Peter's Hospital NHS Trust, Surrey. Zaman Azfar, Freeman Hospital, Newcastle upon Tyne. Hildick-Smith David, Royal Sussex County Hospital, Brighton. Spence Mark, Royal Victoria Hospital, Belfast. Wong Yuk-Ki, Saint Richards Hospital, West Sussex. De Belder Mark, The James Cook University Hospital, Middlesbrough.United States (total enrolment = 976): Abbott J. Dawn, Rhode Island Hospital, Providence, RI. Abu-Fadel Mazen, Oklahoma City Veterans' Affairs Medical Center, Oklahoma City, OK. Albirini Abdulah, Cardiology Associates of Southeast Ohio, Inc., Zanesville, OH. Al-Joundi Bassam, Gateway Cardiology, PC, Saint Louis, MO. Anderson R. David, University of Florida, Gainesville, FL. Angiolillo Dominick, University of Florida Health Sciences Center-Jacksonville, Jacksonville, FL. Applegate Robert, Wake Forest University School of Medicine, Winston-Salem, NC. Assi Nizar, Gateway Cardiology, PC, Saint Louis, MO. Atanasoski-McCormack Violet, Broward General Medical Center, Fort Lauderdale, FL. Atassi Keith, Northwest Indiana Cardiovascular Physicians, Valparaiso, IN. Banerjee Subhash, North Texas Healthcare System, Dept. of Veteran's Affairs, Dallas, TX. Bansal Manish, Baptist Heart Specialists, Jacksonville Beach, FL. Bansal Sharad, Mercy Medical Research Institute, Springfield, MO. Barsness Gregory, Mayo Clinic, Rochester, MN. Batchelor Wayne, Tallahassee Research Institute, Tallahassee, FL. Bavry Anthony, North Florida/South Georgia Veterans Health System, Gainsville, FL. Beohar Nirat, Mount Sinai Medical Center, Miami Beach, FL. Bertolet Barry, Cardiology Associates of North Mississippi, Tupelo, MS. Blankenship James, Geisinger Medical Center, Danville, PA. Bouchard Alain, Cardiology, PC, Birmingham, AL. Brener Sorin, New York Methodist Hospital, Brooklyn, NY. Brott Brigitta, University of Alabama at Birmingham, Birmingham, AL. Caputo Ronald, SJH Cardiology Associates, Liverpool, NY. Carrozza Jr. Joseph, Saint Elizabeth's Medical Center, Boston, MA. Chandna Harish, Victoria Heart and Vascular Center, Victoria, TX. Cohen Martin, Westchester Medical Center, Valhalla, NY. Daniel Kurt, Carolina Cardiology Associates, High Point, NC. Dauber Ira, South Denver Cardiology Associates, PC, Littleton, CO. Davis Scott, Arkansas Cardiology, Little Rock, AR. Devries James, Dartmouth Hitchcock Medical Center, Lebanon, NH. D'Urso Michael, Black Hills Cardiovascular Cardiology Associates P.C., Rapid City, SD. Ellis Stephen, The Cleveland Clinic Foundation, Cleveland, OH. Erickson Bernard, Saint Cloud Hospital,, Saint Cloud, MN. Flores Angel, The Heart and Vascular Center, Beaver, PA. Garas Samer, Saint Vincent's Ambulatory Care, Jacksonville, FL. Gershony Gary, John Muir Medical Center Concord Campus, Concord, CA. Ghali Magdi, Iowa Heart Center, West Des Moines, IA. Ginete Wilson, Essential Health, Duluth, MN. Gogo Jr. Prospero, University of Vermont Medical Center, Fletcher Allen Health Care, Burlington, VT. Gruberg Luis, Stony Brook University Medical Center, Stony Brook, NY. Guidera Steven, Central Bucks Cardiology, Doylestown, PA. Gumina Richard, The Ohio State University Wexner Medical Center, Columbus, OH. Gurbel Paul, Baltimore Heart Associates, Baltimore, MD. Hahn Harvey, Southwest Cardiology, Inc, Kettering, OH. Hahn Richard, The Indiana Heart Hospital, Indianapolis, IN. Hamroff Glenn, Hudson Valley Cardiology Group, PC, Cortlandt Manor, NY. Henderson David, Cardiology Research Associates, Daytona Beach, FL. Iwaoka Robert, Novant Health Heart and Vascular Institute, Charlotte, NC. Izzo Mark, Saint Vincent Health Care Center, Erie, PA. Jafar M. Zubair, Hudson Valley Heart Center, Poughkeepsie, NY. Jayasuriya Sasanka, The University of Arizona, Tucson, AZ. Jenkins J. Stephen, Ochsner Clinic Foundation, New Orleans, LA. Jobe Robert, Wake Heart Research, Raleigh, NC. Jones William, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC. Kaluski Edo, University Medical and Denistry of New Jersey, Newark, NJ. Kander Nathan, Ohio Health Research Institute, Columbus, OH. Kelberman Michael, Central New York Cardiology, Utica, NY. Kiesz Radoslaw, San Antonio Endovascular and Heart Institute, San Antonio, TX. Kim Christopher, Utah Cardiology, PC, Layton, UT. Klag Joseph, Scottsdale Healthcare, Scottsdale, AZ. Krawczyk Justine, Buffalo Cardiology and Pulmonary Associates, PC, Williamsville, NY. Lane Gary, Mayo Clinic Jacksonville, Jacksonville, FL. Langevin Eugene, Freeman West Hospital, Joplin, MO. Lansky Alexandra, Yale University, New Haven, CT. Londono Juan, Future Care Solution, LLC, Hialeah, FL. Lui Henry, Research Associates of Jackson, Jackson, TN. Mahmud Ehtisham, University of California, San Diego, La Jolla, CA. Maini Brijeshwar, Pinnacle Health System, Wormleysburg, PA. Marques Vasco, Pepin Heart Hospital and Dr. Kiran C. Patel Research Institute, Tampa, FL. Martinelli Michael, Albany Associates in Cardiology, Albany, NY. Masud A.R. Zaki, Buffalo Heart Group, Buffalo, NY. McLaurin Brent, AnMed Health, Anderson, SC. Moreno Pedro, Mount Sinai Medical Center, New York, NY. Mulkay Angel, Holy Name Medical Center, Teaneck, NJ. Munuswamy, Karan, Holy Cross Hospital, Fort Lauderdale, FL. Nathan Sandeep, University of Chicago Medical Center, Chicago, IL. Nolan Brian, Saint Luke's Clinic - Idaho Cardiology Associates, Boise, ID. Oswood Bradley, Scottsdale Healthcare, Scottsdale, AZ. Parikh Manish, Columbia University Medical Center, New York, NY. Patel Samir, Cardiovascular Institute of Northwest Florida, Panama City, FL. Pattanayak Jan, Asheville Cardiology Associates, Asheville, NC. Penny William, Veterans Affairs San Diego Healthcare System, San Diego, CA. Petersen John, Swedish Medical Center, Seattle, WA. Ponce George, Spectrum Clinical Research Institute, Inc, Moreno Valley, CA. Portnay Edwardmart, Cardiology Associates of Fairfield County, PC, Stamford, CT. Quintana Ofsman, Valley Central Research, Inc., Mission, TX. Qureshi Mansoor, Michigan Heart, PC, Ypsilanti, MI. Rabah Maher, William Beaumont Hospital, Royal Oak, MI. Rahman, Aref, Veterans Administration Medical Center, Pittsburgh, PA. Revana Madaiah, Humble Cardiology Associates, Humble, TX. Riba Arthur, Oakwood Hospital and Medical Center, Dearborn, MI. Riddick John, Centennial Heart Cardiovascular Consultants, LLC, Nashville, TN. Rouch Carl, Indiana Heart Physicians, Inc., Indianapolis, IN. Rozeman Phillip, Clinical Trials of America, Inc., Minden, LA. Scott, J. Christopher, University of Tennessee, Knoxville, TN. Seals Albert, East Coast Institute for Research, Jacksonville, FL. Seifein Hani, Florida Heart Institute, Orlando, FL. Sharma Mukesh, Parkway Cardiology Associates, Oak Ridge, TN. Shunk Kendrick, San Francisco Veterans Affairs Medical Center, San Francisco, CA. Stine Ronald, Sentara Cardiovascular Research Institute, Norfolk, VA. Tahirkheli Naeem, South Oklahoma Heart Research, Oklahoma City, OK. Talreja Deepak, Cardiovascular Associates, Ltd., Virginia Beach, VA. Teirstein Paul, Scripps Health, La Jolla, CA. Traverse Jay, Minneapolis Heart Institute, Minneapolis, MN. Vasquez Alejandro, Heart Center Research, LLC, Huntsville, AL. Waksman Ron, Washington Hospital Center, Washington, DC. Waltman Jonathan, Saint Joseph Cardiology Associates, KY. Wang John, Union Memorial Hospital, Baltimore, MD. Weinstein Debra, Zasa Clinical Research, Atlantis, FL. Weintraub Andrew, Tufts Medical Center Neely Center for Cancer Research, Boston, MA. Wiseman Alan, Northeast Cardiology Associates, Bangor, ME. Zelman Richard, Cape Cod Research Institute, Hyannis, MA. Zhang Wenwu, Clinical Trials of America, Inc., Shreveport, LA.







































The definition of ICR was anatomy-based with no requirement to prove ischemia or FFR-based functionality

  • The definition of ICR was anatomy-based with no requirement to prove ischemia or FFR-based functionality

  • Anti-anginal medication use (other than ranolazine) was left to local standards, and most patients were on one or two additional anti-ischemia agents

  • There was high rate of study drug discontinuation and the median duration of ranolazine use was shorter, which may have biased the results toward the null



RIVER-PCI is the first trial to have prospectively studied patients with incomplete revascularization after PCI, and to examine the potential role of adjunctive anti-ischemic pharmacotherapy

  • RIVER-PCI is the first trial to have prospectively studied patients with incomplete revascularization after PCI, and to examine the potential role of adjunctive anti-ischemic pharmacotherapy

  • Incomplete revascularization was associated with a high event rate (27% ischemia-driven revascularization or hospitalization at a median follow-up of 1.8 years)

  • Approximately half of ischemia-driven revascularization procedures were performed on the lesions that were left untreated



Routine treatment with ranolazine did not reduce the composite rate of ischemia-driven revascularization or hospitalization in patients with a history of chronic angina who had incomplete revascularization after PCI

  • Routine treatment with ranolazine did not reduce the composite rate of ischemia-driven revascularization or hospitalization in patients with a history of chronic angina who had incomplete revascularization after PCI

  • No differences in the primary endpoint were observed with ranolazine in any pre-specified subgroup, or in the secondary endpoints of sudden cardiac death, CV death or MI

  • There were no major safety concerns with ranolazine other than a higher rate of mild adverse events resulting in study drug discontinuation






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