MYCOPLASMA AND UREOPLASMA - DR MONIKA RAJANI
- ASSOCIATE PROFESSOR ,
- DEPT OF MICROBIOLOGY
- CIMSH ,LKO
MYCOPLASMA - GENERAL CHARACTERS
- Smallest free living microorganisms that can be grown in cell free media
- BACTERIA -Devoid of cell wall-pleomorphic.
- -Resistant to cell wall active antibiotics
- Trilaminar cell membrane contains sterols.
- Can pass through bacterial filters of 450nm pore size.
- Have both DNA and RNA.
- Require sterols for growth as a growth
- factor in culture medium .
- Self replicating,multiply by binary fission
HISTORY - The name Mycoplasma –Greek word: mykes-fungus and plasma-plasticity of shape
- PPLO(pleuropneumonia like organisms)- as first known to cause- Bovine Pleuropneumonia
- EATONS AGENT:(virus like as filterable)
- Eaton was first to isolate the causative agent of primary atypical pneumonia in hamsters and cotton rats.
- Subsequently shown to be a Mycoplasma and so named M pneumoniae
MORPHOLOGY - Lack cell wall
- Granules and branched filamentous
- forms
- Cocoid,balloon,star,disc or ring forms.
- No spores ,capsule or flagella.
- Stain poorly with gram stain
- Stained by Giemsa stains.
- Gliding motility due to specialised tip structures
Differences from bacteria and viruses - No cell wall
- Cell membrane has sterols
- No DNA homology with bacteria
- Low guanine plus cytosine content
- filterable
- Grow on cell free media in vitro
- Have both DNA and RNA
- Show both extra as well as intra cellular parasitism.
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