Original Research Features of the Immunological Nature in Children with Atopic Dermatitis

CONCLUSIONS

Thus, it was found that the levels of cytokines in the blood serum reflect the current state of the immune system of patients with AD. Summing up the study of the serum cytokine content in patients with AD of varying severity, we can conclude that there is a tendency to increased production of anti-inflammatory cytokines (IL-4 and IL-6) during exacerbation of the disease and an increase in the synthesis of pro-inflammatory cytokines (TNF -α) during remission. This may indicate the activation of the production of cytokines of both Th2 and Th17 types. In general, the polarization of Th2 and Th17 towards an increase in functional activity in the acute period corresponds to the classical concepts of the immunopathogenesis of atopic inflammation.
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Journal of Advanced Economic Sciences Research |Vol. 9|Issue 4| April 2021