- Oxygen is more readily released to the tissues (decreased oxygen affinity) when
- Decreased Ph (acidosis),
- Increased PaCO2 (respiratory acidosis)
- Increased body temperature (hyperthermia)
- Increased 2,3-diphosphoglycerate level (a by –product of glucose metabolism also found in stored blood products)
When hemoglobin has greater affinity for oxygen, less is available to the tissue (increased oxygen affinity) increase oxygen binding to the hemoglobin and limit its release to the tissue. Conditions such as - When hemoglobin has greater affinity for oxygen, less is available to the tissue (increased oxygen affinity) increase oxygen binding to the hemoglobin and limit its release to the tissue. Conditions such as
- Increased ph (alkalosis)
- Decreased PaCO2 (respiratory alkalosis)
- Decreased temperature (hypothermia)
- Decreased 2,3-diphosphoglycerate level.
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