R e s e a r c h a r t I c L e

Cite this article as: Ravindran et al., Comparison of BCG, MPL and cationic 
liposome adjuvant systems in leishmanial antigen vaccine formulations 
against murine visceral leishmaniasis BMC Microbiology 2010, 10:181

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Document Outline

• Abstract
  • Background
  • Results
  • Conclusion
• Background
• Results
  • Comparison of parasite burden in differently adjuvanted LAg vaccinated mice after L. donovani challenge infection
  • Antigen-specific humoral responses in differently adjuvanted LAg vaccinated mice
  • Stimulation of DTH response in differently adjuvanted LAg vaccinated mice
  • Generation of IFN-. and IL-4 response in differently adjuvanted LAg vaccinated mice
• Discussion
• Conclusions
• Methods
  • Animals
  • Parasites and culture condition
  • Preparation of leishmanial antigens
  • Adjuvants
  • Entrapment of leishmanial antigens into cationic liposomes
  • Vaccination and challenge infection
  • Evaluation of infection
  • Antigen-specific antibody responses by ELISA
  • Delayed type hypersensitivity (DTH)
  • Cytokine Assay
  • Statistical analysis
• Abbreviations
• Authors' contributions
• Acknowledgements
• Author Details
• References