Simulation software: applications and results in the bio-medical domain


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Simulation software: applications and results in the bio-medical domain From HEP computing to bio-medical research and vice versa




Requirements for LowE p in

  • UR 2.1 The user shall be able to simulate electromagnetic interactions of positive charged hadrons down to < 1 KeV.

  • Need: Essential

  • Priority: Required by end 1999

  • Stability: T. b. d.

  • Source: Medical physics groups, PIXE

  • Clarity: Clear

  • Verifiability: Verified





…and validation



What could be the source of detector damage?





What happened next?





Low energy e,  extensions





Photon attenuation: vs. NIST data



…the first user application



…and the same requirements in HEP too

  • Similar requirements on both low energy e/ and hadrons, K-shell transitions etc. from “underground” HEP experiments collected ~1 year later

  • Recent interest on these physics models from LHC for precision detector simulation

  • They profit of the fact that the code









Physics requirements



Guidelines for physics



Software Engineering









Endocavitary brachytherapy





Source anisotropy



RBE enhancement of a 125I brachytherapy seed with characteristic X-rays from its constitutive materials



Results (RBE at 1 cm)



Results of the study





testing and validation



Comparison with commercial treatment planning systems



A more complex set-up



Many other applications and new projects



- DNA

  • Relevance for space: astronaut and airline pilot radiation hazards, biological experiments

  • Applications in radiotherapy, radiobiology...



User Requirements

  • It is a complex field

  • Complexity increased by the multi-disciplinary nature of the project

    • no one masters all the scientific components (biology, chemistry, physics etc.)


What benefits for HEP?





in Savona



Meditations…

  • HEP computing has a potential for technology transfer

    • not only the WWW…
    • not only Geant4…
  • The role of HEP: expertise, but also reference

    • Physics and software engineering expertise
    • Reference to many small groups and diverse activities
  • Technology transfer: collaboration rather than colonisation

    • Valuable contributions from the medical domain (requirements, testing, rigorous methodologies…)
    • New resources into projects of common interest
    • Plenty of valuable applications and results


Thanks!

  • ESA/ESTEC (R. Nartallo, P. Nieminen)

  • INFN Cosenza (E. Lamanna)

  • INFN Torino (S. Chauvie, R. Gotta, F. Marchetto, V. Rolando, A. Solano)

  • IST (S. Agostinelli, R. Corvo, F. Foppiano, S. Garelli, G. Sanguineti, M. Tropeano)

  • LIP (P. Rodrigues, A. Trindade)

  • Univ. Laval / UCSF (R. Taschereau)

  • PSI (N. Crompton, P. Juelke)

  • Savona Hospital (G. Ghiso, R. Martinelli)

  • Geant4 medical users (impossible to mention all…)

  • Geant4 Collaboration

  • CERN (G. Cosmo, S. Giani, J. Knobloch)




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