The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons

J.L. Labandeira-Garcia et al.

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Document Outline

• The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons
  • 1 Introduction
  • 2 The brain RAS. Dopamine and RAS
  • 3 The intracellular RAS
  • 4 The mitochondrial RAS
    • 4.1 The presence of RAS components in the mitochondria
    • 4.2 Functional effects of the mitochondrial angiotensin receptors
    • 4.3 Mitochondrial RAS in aging and disease
    • 4.4 Possible role of mitochondrial ACE2 in the cellular effects of SARS-CoV-2 and COVID-19 disease
  • 5 The nuclear RAS
    • 5.1 The presence of RAS components in the nucleus
    • 5.2 Activation of nuclear RAS components after nuclear translocation of the Ang II/AT1 complex
    • 5.3 Other possible protective mechanisms induced by nuclear Ang II/AT1 activation
    • 5.4 Nuclear AT1 receptor activation induces an increase in nuclear Ca2+ and superoxide/H2O2 levels
    • 5.5 Nuclear RAS in aging and disease
  • 6 Additional intracellular mechanisms counteract the pro-oxidative effects of the paracrine Ang II/AT1 axis
  • 7 Conclusions and perspectives for the future
  • Declaration of Competing Interest
  • Acknowledgements
  • Appendix A The Peer Review Overview and Supplementary data
  • References