Tuberculosis in Adults and Children


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Tuberculosis in Adults and Children

Document Outline

  • Preface
  • Contents
  • 1 Epidemiology
    • Abstract
    • 1.1 Tuberculosis in History
    • 1.2 Pathogen
    • 1.3 Epidemiology
    • 1.4 Prognosis
  • 2 Pathogenesis
    • Abstract
    • 2.1 Transmission
    • 2.2 The Innate Immune Response
    • 2.3 The Adaptive Immune Reponse
    • 2.4 The Complex Role of TNF and Its Genetic Control
    • 2.5 The Tuberculoma
    • 2.6 Vitamin D and the Immune Response
      • 2.6.1 Vitamin D Metabolism
      • 2.6.2 Antimicrobial Effects of Vitamin D
      • 2.6.3 Vitamin D Deficiency and Susceptibility to Tuberculosis
  • 3 Clinical Manifestations
    • Abstract
    • 3.1 Primary Tuberculosis
    • 3.2 Pulmonary Tuberculosis
      • 3.2.1 Parenchymal Disease
      • 3.2.2 Endobronchial Tuberculosis
      • 3.2.3 Intra-Thoracic Lymphnode Disease
    • 3.3 Extra-Pulmonary Tuberculosis
      • 3.3.1 Pleural Tuberculosis
      • 3.3.2 Miliary Tuberculosis
      • 3.3.3 Extra-Thoracic Lymphnode Disease
      • 3.3.4 Central Nervous System Tuberculosis
      • 3.3.5 Tuberculous Pericarditis
      • 3.3.6 Spinal Tuberculosis
      • 3.3.7 Other Forms of Extra-Pulmonary Tuberculosis
  • 4 Diagnosis
    • Abstract
    • 4.1 Smear Microscopy
    • 4.2 Mycobacterial Culture
    • 4.3 Nucleic Acid Amplification Tests
    • 4.4 Diagnosing Drug-Resistant Tuberculosis
    • 4.5 Other Diagnostic Methods
    • 4.6 Diagnosing Latent Tuberculosis Infection
  • 5 Treatment
    • Abstract
    • 5.1 First-Line Antituberculous Treatment
    • 5.2 HIV Associated Tuberculosis
    • 5.3 Treatment of Drug-Resistant Tuberculosis
    • 5.4 The Role of Fluoroquinolones
    • 5.5 Bedaquiline
    • 5.6 Delamanid
  • 6 Prevention
    • Abstract
    • 6.1 Prophylactic Treatment
    • 6.2 Prophylactic Treatment in Multi-drug Resistant Tuberculosis
    • 6.3 Vaccines
    • 6.4 Concluding Remarks
  • References
  • Index

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