Zirak Hasan, Milladur Rahman, Karzan Palani, Ingvar Syk, Bengt Jeppsson, and Henrik Thorlacius
Download 229.75 Kb. Pdf ko'rish
|
ACKNOWLEDGMENTS This work was supported by grants from the Swedish Medical Research Council (2009-4872), Crafoordska stiftelsen, Einar och Inga Nilssons stiftelse, Harald och Greta Jaenssons stiftelse, Greta och Johan Kocks stiftelser, Fröken Agnes Nilssons stiftelse, Franke och Margareta Bergqvists stiftelse för främ- jande av cancerforskning, Magnus Bergvalls stiftelse, Mossfelts stiftelse, Nanna Svartz stiftelse, Ruth och Richard Julins stiftelse, Svenska Läkaresäll- skapet, Allmäna sjukhusets i Malmö stiftelse för bekämpande av cancer, MAS fonder, Malmö University Hospital and Lund University. Z. Hasan and K. Palani are supported by a fellowship from Kurdistan regional government. DISCLOSURES No conflicts of interest, financial or otherwise, are declared by the author(s). AUTHOR CONTRIBUTIONS Z.H. and H.T. conception and design of research; Z.H., M.R., and K.P. performed experiments; Z.H., M.R., K.P., and H.T. analyzed data; Z.H., M.R., and H.T. interpreted results of experiments; Z.H. prepared figures; Z.H., M.R., K.P., I.S., B.J., and H.T. drafted manuscript; Z.H., M.R., K.P., I.S., B.J., and H.T. edited and revised manuscript; Z.H., I.S., B.J., and H.T. approved final version of manuscript.
1. Arnaud C, Veillard NR, Mach F. Cholesterol-independent effects of statins in inflammation, immunomodulation and atherosclerosis. Curr
L228
GERANYLGERANYL TRANSFERASE AND ABDOMINAL SEPSIS AJP-Lung Cell Mol Physiol • doi:10.1152/ajplung.00199.2012 • www.ajplung.org by 10.220.33.2 on October 20, 2017 http://ajplung.physiology.org/ Downloaded from
2. Asaduzzaman M, Lavasani S, Rahman M, Zhang S, Braun OO, Jeppsson B, Thorlacius H. Platelets support pulmonary recruitment of neutrophils in abdominal sepsis. Crit Care Med 37: 1389 –1396, 2009. 3. Asaduzzaman M, Rahman M, Jeppsson B, Thorlacius H. P-selectin glycoprotein-ligand-1 regulates pulmonary recruitment of neutrophils in a platelet-independent manner in abdominal sepsis. Br J Pharmacol 156: 307–315, 2009. 4. Asaduzzaman M, Zhang S, Lavasani S, Wang YS, Thorlacius H. LFA-1 and Mac-1 mediate pulmonary recruitment of neutrophils and tissue damage in abdominal sepsis. Shock 30: 254 –259, 2008. 5. Babayigit H, Kucuk C, Sozuer E, Yazici C, Kose K, Akgun H. Protective effect of beta-glucan on lung injury after cecal ligation and puncture in rats. Intensive Care Med 31: 865–870, 2005. 6. Balk RA. Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations. Crit Care Clin 16: 179 –192, 2000. 7. Beltowski J, Wójcicka G, Jamroz-Wisniewska A. Adverse effects of statins — mechanisms and consequences. Curr Drug Saf 4: 209 –228, 2009. 8. Berndt N, Hamilton AD, Sebti SM. Targeting protein prenylation for cancer therapy. Nat Rev Cancer 11: 775–791, 2011. 9. Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J 348: 241–255, 2000. 10. Carraway MS, Welty-Wolf KE, Miller DL, Ortel TL, Idell S, Ghio AJ, Petersen LC, Piantadosi CA. Blockade of tissue factor: treatment for organ injury in established sepsis. Am J Respir Crit Care Med 167: 1200 –1209, 2003. 11. Chiba Y, Sato S, Misawa M. GGTI-2133, an inhibitor of geranylgera- nyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma. Int J Immunopathol Pharmacol 22: 929 –935, 2009. 12. Cohen J. The immunopathogenesis of sepsis. Nature 420: 885–891, 2002. 13. Czermak BJ, Breckwoldt M, Ravage ZB, Huber-Lang M, Schmal H, Bless NM, Friedl HP, Ward PA. Mechanisms of enhanced lung injury during sepsis. Am J Pathol 154: 1057–1065, 1999. 14. del Real G, Jimenez-Baranda S, Mira E, Lacalle RA, Lucas P,
down-regulating Rho activity. J Exp Med 200: 541–547, 2004. 15. Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adja- cent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc
16. Hasan Z, Palani K, Rahman M, Thorlacius H. Targeting CD44 ex- pressed on neutrophils inhibits lung damage in abdominal sepsis. Shock 36: 431–431, 2011. 17. Hasan Z, Palani K, Rahman M, Zhang S, Syk I, Jeppsson B, Thor-
phils in abdominal sepsis via attenuation of cxc chemokine formation and Mac-1 expression on neutrophils. Shock 37: 282–288, 2012. 18. Khan OM, Ibrahim MX, Jonsson IM, Karlsson C, Liu M, Sjogren AK, Olofsson FJ, Brisslert M, Andersson S, Ohlsson C, Hulten LM, Bokarewa M, Bergo MO. Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. J Clin Invest 121: 628 –639, 2011. 19. Kostopanagiotou GG, Kalimeris KA, Arkadopoulos NP, Pafiti A, Panagopoulos D, Smyrniotis V, Vlahakos D, Routsi C, Lekka ME, Nakos G. Desferroxamine attenuates minor lung injury following surgical acute liver failure. Eur Respir J 33: 1229 –1236, 2009. 20. Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87: 1344 – 1350, 1984. 21. Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physi- ology and pathophysiology. Circ Res 98: 322–334, 2006. 22. Matsuda N, Hattori Y, Jesmin S, Gando S. Nuclear factor-kappa B decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol Pharmacol 67: 1018 –1025, 2005.
23. Merx MW, Liehn EA, Graf J, van de Sandt A, Schaltenbrand M, Schrader J, Hanrath P, Weber C. Statin treatment after onset of sepsis in a murine model improves survival. Circulation 112: 117–124, 2005. 24. Merx MW, Liehn EA, Janssens U, Lutticken R, Schrader J, Hanrath
proves survival in a murine model of sepsis. Circulation 109: 2560 –2565, 2004. 25. Narumiya S. The small GTPase Rho. Cellular functions and signal transduction. J Biochem 120: 215–228, 1996. 26. Rahman M, Zhang S, Chew M, Ersson A, Jeppsson B, Thorlacius H. Platelet-derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg 250: 783–790, 2009. 27. Rao PV, Peterson YK, Inoue T, Casey PJ. Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. Invest Ophthalmol Vis Sci 49: 2464 –2471, 2008. 28. Remick DG. Pathophysiology of sepsis. Am J Pathol 170: 1435–1444, 2007. 29. Rios-Santos F, Alves-Filho JC, Souto FO, Spiller F, Freitas A, Lotufo CMC, Botelho M, Soares P, dos Santos RR, Teixeira MM, Cunha FdQ. Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. Am J Respir Crit Care Med 175: 490 –497, 2007. 30. Rollins BJ. Chemokines. Blood 90: 909 –928, 1997. 31. Simon GL, Gorbach SL. Intestinal flora in health and disease. Gastro-
32. Stern RH, Yang BB, Hounslow NJ, MacMahon M, Abel RB, Olson SC. Pharmacodynamics and pharmacokinetic-pharmacodynamic relation- ships of atorvastatin, an HMG-CoA reductase inhibitor. J Clin Pharmacol 40: 616 –623, 2000. 33. Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev 81: 153–208, 2001. 34. Tekamp-Olson P, Gallegos C, Bauer D, McClain J, Sherry B, Fabre M, Vandeventer S, Cerami A. Cloning and characterization of cDNAs for murine macrophage inflammatory protein-2 and its human homologs. J Exp Med 172: 911–919, 1990. 35. Terblanche M, Almog Y, Rosenson R, Smith TS, Hackam DG. Statins and sepsis: multiple modifications at multiple levels. Lancet Infect Dis 7: 358 –368, 2007. 36. Waiczies S, Bendix I, Prozorovski T, Ratner M, Nazarenko I, Pfueller
lation but not GTP loading determines rho migratory function in T cells. J Immunol 179: 6024 –6032, 2007. 37. Walters CE, Pryce G, Hankey DJ, Sebti SM, Hamilton AD, Baker D, Greenwood J, Adamson P. Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis. J Immunol 168: 4087–4094, 2002. 38. Weber C, Erl W, Weber KSC, Weber PC. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of mono- cytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol 30: 1212–1217, 1997. 39. Yokoyama K, McGeady P, Gelb MH. Mammalian protein geranylgera- nyltransferase-I: substrate-specificity, kinetic mechanism, metal require- ments, and affinity labeling. Biochemistry 34: 1344 –1354, 1995. 40. Zhang S, Rahman M, Herwald H, Qi Z, Jeppsson B, Thorlacius H. Streptococcal M1 protein-provoked CXC chemokine formation, neutro- phil recruitment and lung damage are regulated by Rho-kinase signaling.
41. Zhang S, Rahman M, Zhang S, Qi Z, Thorlacius H. Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis. J Leukoc Biol 89: 735–742, 2011. 42. Zhang X, Goncalves R, Mosser DM. The isolation and characterization of murine macrophages. Curr Protoc Immunol 14: Unit 14.1, 2008. 43. Zhang XW, Liu Q, Wang YS, Thorlacius H. CXC chemokines, MIP-2 and KC, induce P-selectin-dependent neutrophil rolling and extravascular migration in vivo. Br J Pharmacol 133: 413–421, 2001. 44. Zhou Q, Liao JK. Pleiotropic effects of statins: basic research and clinical perspectives. Circ J 74: 818 –826, 2010. 45. Zlotnik A, Morales J, Hedrick JA. Recent advances in chemokines and chemokine receptors. Crit Rev Immunol 19: 1–47, 1999. L229 GERANYLGERANYL TRANSFERASE AND ABDOMINAL SEPSIS AJP-Lung Cell Mol Physiol • doi:10.1152/ajplung.00199.2012 • www.ajplung.org by 10.220.33.2 on October 20, 2017 http://ajplung.physiology.org/ Downloaded from Download 229.75 Kb. Do'stlaringiz bilan baham: |
ma'muriyatiga murojaat qiling