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Principles of Immunology Introduction/ Historical Perspectives 1/17/06


Historical Events in Immunology

  • 1796-Edward Jenner (smallpox)

  • 1881-Loius Pasteur (vaccines)

  • 1884-Elie Metchnikoff (phagocytes)

  • 1890-Emil von Behring* (antibodies)

  • 1895-Jules Bordet* (complement)

  • 1906-August Wasserman (syphilis)



Historical Events in Immunology (cont’d)

  • 1959-Rodney Porter Gerald Edelman* (antibodies)

  • 1960-F McFarlane Burnet* (tolerance)

  • 1975-Cesar Milstein*(monoclonal Ab)

  • 1987-Susumu Tonegawa* (genetics)

  • 1996-Peter Doherty

  • Rolf Zinkernagel* (MHC)



Sub disciplines of Immunology

  • Immunobiology

  • Immunochemistry

  • Immunopathology

  • Immunogenetics

  • Immunodiagnostics

  • Immunotherapy



Overview of the Immune System

  • Innate immunity

    • Pre-existing
    • Non-specific
  • Adaptive immunity

    • Responsive
    • Specific


Cells of the Immune System

  • Phagocytic cells

    • Nonspecific
    • Specific
  • Lymphocytes



Two Arms of the Adaptive Immune System

  • Humoral immunity

    • Antibodies
  • Cell-mediated immunity

    • T-cells


Immunological Memory



Chemical Mediators

  • Extracellualar

    • Cytokines
    • Complement
  • Intracellular



Antigens and Antibodies

  • Antigens

  • Antibodies

    • Chemical makeup
    • Roles
    • Functions


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