Level Level Introductory Genetics


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Provides a hands-on activity for students to identify and examine transcription factor binding sequences, and evaluate the effect of variations in these sequences.

  • Provides a hands-on activity for students to identify and examine transcription factor binding sequences, and evaluate the effect of variations in these sequences.

























Use your clicker to indicate the SRY binding site in your sequence.

  • Use your clicker to indicate the SRY binding site in your sequence.

  • A: AACTAT

  • B: AACAAT

  • C: AACAAA

  • D: AACTAA













SRY is a transcription factor that regulates genes needed for development of male-specific structures (e.g., testes) and male-specific traits

  • SRY is a transcription factor that regulates genes needed for development of male-specific structures (e.g., testes) and male-specific traits





SRY Mutations

  • SRY Mutations

    • Cause of 10-15% of cases of 46(X,Y) gonadal dysgenesis
    • Some of these are nonsense or frameshift mutations that lead to nonfunctional protein
    • Many are missense mutations that affect the DNA binding ability of the SRY protein.










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