Arch Iran Med. 2010 Sep;13(5):384-90. Association Study of The -866G/A UCP2 Gene Promoter
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Arch Iran Med. 2010 Sep;13(5):384-90.
Association Study of The -866G/A UCP2 Gene Promoter
Polymorphism with Type 2 Diabetes and Obesity in a
Tehran Population: A Case Control Study.
Heidari J, Akrami SM, Heshmat R, Amiri P, Fakhrzadeh H, Pajouhi M.
Endocrinology and Metabolism Research Center, Tehran University of
Medical Sciences, Tehran, Iran.
BACKGROUND: A functional polymorphism in the uncoupling protein 2
(UCP2) gene promoter has been associated with obesity and type 2
diabetes (T2D) in some popula ons. The impact of UCP2 polymorphisms on
diabetes and obesity is still under debate. Contradictory results have been
reported in different populations world-wide. To clarify the contribution of
the UCP2 gene -866 G/A polymorphism in the Iranian popula on, we
studied its associa on with obesity and T2D.
without obesity, 75 obese pa ents without diabetes and 75 control
subjects. The UCP2 -866 G/A polymorphism was determined by polymerase
chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS: In the normal Iranian population, GG polymorphism was
significantly associated with an increased HDL-C level (P=0.027). G/A
polymorphism was not associated with obesity and T2D in our study
population, but the odds ratio (OR) between GG and G/A polymorphism
was 0.61 with a conﬁdence interval (CI) range of 0.34 - 1.08 in obese
patients. Subjects with AA genotypes in all of the studied groups showed a
lower body mass index (BMI) than subjects with the GG genotype.
signiﬁcant, the A allele in the UCP2 gene promoter seems to be protective
against obesity. This may suggest the possibility of UCP2 as a target
molecule for studies on the etiology and treatment of obesity.
Med Oncol. 2010 Jul 27. [Epub ahead of print]
Body Mass Index and Waist Circumference are Predictor
Biomarkers of Breast Cancer Risk in Iranian Women.
Hajian-Tilaki KO, Gholizadehpasha AR, Bozorgzadeh S, Hajian-Tilaki E.
Department of Social Medicine and Health, Babol University of Medical
Sciences, Babol, Iran, firstname.lastname@example.org.
Both obesity and breast cancer incidence increased dramatically during two
recent decades in a rapidly changing society in northern Iran. In this study,
we examined the ability of body mass index (BMI) and waist circumference
(WC) as predictor biomarkers of breast cancer risk in Iranian women. In a
case-control study of 100 new cases of histological conﬁrmed breast cancer
and 200 age-matched controls, in Babol, we measured weight, height, waist
and hip circumference at time of diagnosis with standard methods. The
data of demographic, characteristics, reproductive and lifestyle factors
were collected by interview. We used both regression and receiver
operator characteristics (ROC) analysis to estimate the predictive ability of
BMI and WC for breast cancer as estimated by area under the curve (AUC).
The results showed a significant difference in the mean of weight, BMI and
WC between patients and controls in pre- and postmenopausal women (P <
0.001). While a er adjus ng for BMI, no longer an associa on between WC
and breast cancer was found. The overall accuracy of observed BMI and WC
were 0.79 (95% CI: 0.74-0.84) and 0.68 (95% CI: 0.61-0.74), respec vely.
The accuracy of BMI and WC were 0.82 (95% CI: 0.76-0.89), 0.75(0.67-0.83)
postmenopausal women, respectively. BMI and WC are predictor
biomarkers of breast cancer risk in both pre- and postmenopausal Iranian
women while after adjusting for BMI, no longer an association between WC
and breast cancer was observed. These findings imply to perform breast
cancer screening program in women with a higher BMI and WC.
J Res Med Sci. 2010 Jul;15(4):191-201.
The Influence of Calcium Supplement on Body
Composition, Weight Loss and Insulin Resistance in Obese
Adults Receiving Low Calorie Diet.
Shalileh M, Shidfar F, Haghani H, Eghtesadi S, Heydari I.
Nutrition Sciences Department, Faculty of Health, Iran University of Medical
Sciences, Tehran, Iran.
BACKGROUND: Obesity and diabetes are the most important problems of
public health. Evidence from molecular animal research and epidemiologic
investigations indicate that calcium intake may have an influence on body
composition, weight and insulin resistance. The objective of this study was
to determine the effects of calcium supplementation on body composition,
weight, insulin resistance and blood pressure in the face of calorie
restriction in obese adults.
adults with Body Mass Index > 25kg/m(2) was conducted. Subjects were
maintained for 24 weeks on a balanced deﬁcit diet (-500 kcal/d deﬁcit) and
randomly assigned into two groups with 1000 mg ca/d as calcium carbonate
24th week between the two groups. The lean mass showed no signiﬁcant
increase in the calcium group at the 12th week compared to baseline and in
placebo group at the 24th week compared to the 12th week. The insulin
concentration showed a significant decrease in the calcium group at the
12th week compared to the baseline (p < 0.05). The diastolic blood pressure
had a signiﬁcant decrease at the 24th week compared to the 12th week in
both groups (p = 0.013-0.009).
CONCLUSIONS: Results from this study suggest that 24 weeks of
supplementa on with 1000 mg ca/d did not have any eﬀect on weight,
body composition, insulin resistance and blood pressure beyond what can
be achieved in an energy restricted diet in obese adults.
Matern Child Nutr. 2010 Jul 1;6(3):275-86.
Effects of a Lifestyle Modification Trial among
Adolescents in Comparison with Phenotypically Normal
Metabolically Obese Adolescents.
Kelishadi R, Hashemipour M, Sarrafzadegan N, Mohammadifard N, Alikhasy
H, Beizaei M, Sajjadi F, Poursafa P, Amin Z, Ghatreh-Samani S, Khavarian N,
Pediatric Preventive Cardiology Department, Isfahan Cardiovascular
Research Center, Isfahan University of Medical Sciences, Iran.
This study aimed to assess the eﬀects of a 2-month lifestyle modification
trial on cardio-metabolic abnormalities and C-reactive protein (CRP) among
obese adolescents with metabolic syndrome [phenotypically obese
metabolically abnormal (POMA)] and obese adolescents without a cardio-
metabolic disorder [phenotypically obese metabolically normal (POMN)], as
well as in normal-weight adolescents with at least one cardio-metabolic
disorder [phenotypically normal metabolically obese (PNMO)]. The study
comprised 360 adolescents assigned in three groups of equal number of
POMN, POMA and PNMO. They were enrolled in a trial consisting of aerobic
ac vity classes, diet and behaviour modiﬁca on, and were recalled a er 6
months. Overall, 94.7% of par cipants completed the 2-month trial, and
87.3% of them returned a er 6 months. The mean CRP was not significantly
different between the POMA and PNMO groups, but was higher than in the
POMN group. After the trial, body mass index (BMI) and waist
circumference (WC) decreased in obese participants, and the mean body
fat mass decreased in all groups. At 2 months, the mean total cholesterol
(TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and CRP
decreased in the POMA and PNMO groups. A er 2 and 6 months, the
decrease in mean TC, LDL-C, TG, CRP and systolic blood pressure was
greater in the POMA than in the POMN group. The magnitude of decrease
in CRP correlated with that of BMI, WC, fat mass, TG, TC and LDL-C. Lifestyle
modification programmes for primordial/primary prevention of chronic
diseases would be beneficial at the population level and should not be
limited to obese children.
Ther Clin Risk Manag. 2010 Jul 21;6:345-9.
Prevalence of Impaired Glucose Tolerance and Insulin
Resistance among Obese Children and Adolescents.
Ghergherechi R, Tabrizi A.
Department of Pediatrics Endocrinology, Tabriz University of Medical
Sciences, Tabriz, Iran;
PURPOSE: Obesity is one of the most important nutritional disorders in the
world which has an obvious relationship with the incidence of metabolic
diseases. Obesity prevalence has increased among children and adolescents
during recent decades, leading to a rise in Type 2 diabetes mellitus (DM II)
prevalence in these two age brackets. Hence, the aim of this study was to
assess impaired glucose tolerance and insulin resistance, and gather
metabolic findings in obese children and adolescents.
adolescents (body mass index > 95th percen le for age and gender) 4-18
years of age referred to the endocrine clinic of the Children's Hospital at
Tabriz University in a descriptive cross-sectional study. Fasting glucose,
insulin, and lipid profile in all subjects were determined. Oral glucose
tolerance test a er ea ng 75 g/kg glucose was performed. Homeostatic
model assessment was used to estimate insulin resistance.
68 obese adolescents was 14.7% and 31.8%, respec vely. Impaired glucose
tolerance and insulin resistance was not seen in 23.8% of 42 obese children.
No case of DM II was seen. There was a significant statistical difference in
glucose (P = 0.003) and insulin (P < 0.001) level at minute 120 in individuals
with impaired glucose tolerance compared to obese children and
adolescents without impaired glucose tolerance. Rate of insulin resistance
in patients with impaired glucose tolerance was greater and had a
signiﬁcant sta s cal diﬀerence (P = 0.03).
impaired glucose tolerance and insulin resistance in children and
adolescents. Oral glucose tolerance test, unlike fasting glucose test, is a
benefit test to predict impaired glucose tolerance. With prompt
identification and treatment of obese children with impaired glucose
tolerance, we can prevent it from progression towards DM II.
J Public Health (Oxf). 2010 Jun;32(2):202-9. Epub 2009 Aug 18.
Association of Educational Level with Risk of Obesity and
Abdominal Obesity in Iranian Adults.
Hajian-Tilaki KO, Heidari B.
Department of Social Medicine and Health, Babol Faculty of Medicine,
Babol University of Medical Sciences, Babol, Iran. email@example.com
BACKGROUND: The impact of education on obesity may vary according to
population and geographic region. The objective of the present study was
to determine the association between education and obesity.
conducted by using a cluster sampling technique in an adult population
residing in the north of Iran, in 2004. Weight, height, waist and hip
circumference were measured and data concerning education level,
demographic characteristics and physical activities were collected by
interview. Logistic regression analysis was used to estimate the association
between educa on and general obesity (body mass index >or=30) as well as
abdominal obesity (waist circumference >88 cm in women and 102 cm in
level of high school and college compared with illiterate and primary level
was 0.55 [95% conﬁdence interval (CI): 0.43-0.71]. A greater nega ve
associa on was observed for educa on at university level (OR = 0.32, 95%
CI: 0.22-0.47) irrespec ve to sex. However, with regard to abdominal
obesity, after controlling for confounding factors, the adjusted OR for
education at university level remained significant only in women but not in
CONCLUSION: The findings of this study indicate that education level is
inversely associated with general obesity in both sexes but with abdominal
obesity only in women.
J Clin Epidemiol. 2010 Jun;63(6):655-9. Epub 2009 Nov 12.
Pictogram Use Was Validated for Estimating Individual's
Body Mass Index.
Keshtkar AA, Semnani S, Pourshams A, Khademi H, Roshandel G, Boffetta P,
Golestan Research Center of Gastroenterology and Hepatology, Golestan
University of Medical Sciences, Gorgan, Iran.
pictogram for estimating body mass index (BMI).
STUDY DESIGN AND SETTING: Participants of Golestan cohort study during
2000-2004 were recruited in this study. Demographic and anthropometric
information (weight, height, and BMI) were collected on all participants. A
set of drawings (pictogram) ranging from very lean to obese were used to
assess the individual's perception of their body size. Sensitivity and
specificity of each pictogram score were calculated and cutoff points were
determined using sensitivity/specificity plots. We used receiver operating
characteristic curves to assess the validity of pictogram scores.
RESULTS: Of the 15,437 subjects enrolled in the study, 6,574 (42.6%) were
males and 8,863 (57.4%) were females. Their mean+/-standard deviation
age was 52.58+/-9.28 years. Pictogram scores 1, 2, and 3 were assigned to
normal par cipants; pictogram score 4 was selected by overweight
subjects, and ﬁnally, pictogram scores equal or higher than 5 were selected
by obese ones (area under curve: 0.83-0.85).
CONCLUSION: According to our results, pictogram is a valid measure for
discriminating obese or overweight from normal individuals, and for
distinguishing obese from overweight or normal individuals. So it can be
concluded that body image pictogram is valid for discriminating normal and
Metab Syndr Relat Disord. 2010 Jun;8(3):209-13.
Secular Trends of Obesity in Iran between 1999 and 2007:
National Surveys of Risk Factors of Non-Communicable
Esteghamati A, Khalilzadeh O, Mohammad K, Meysamie A, Rashidi A,
Kamgar M, Abbasi M, Asgari F, Haghazali M.
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital,
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
BACKGROUND: Obesity is a rapidly progressing pandemic and a central
feature of the metabolic syndrome. There is no solid evidence on the recent
trends of obesity in Iran. In this study we present the secular trends of
overweight and obesity among Iranian adults (25-64 years old) within an 8-
year period (1999-2007).
sectional national surveys: The National Health Survey-1999 (n = 21,576),
National Surveys of Risk Factors for Non-Communicable Diseases
(SuRFNCD)-2005 (n = 70,945), and SuRFNCD-2007 (n = 4,186).
RESULTS: The overall prevalence of obesity increased from 13.6% in 1999
to 19.6% in 2005 and 22.3% in 2007 [odds ra o (OR) = 1.08 per year; P <
0.001]. For overweight subjects, the rates were, respec vely, 32.2%, 35.8%
and 36.3% (OR = 1.02 per year; P < 0.001). During these years, the mean
body mass index (BMI) (kg/m(2)) increased from 25.03 in 1999, to 26.14 in
2005, and 26.47 and 2007 (P < 0.001). The increase in prevalence of obesity
was seen in both males (OR = 1.09 per year; P < 0.001) and females (OR =
1.07 per year; P < 0.001) and both urban (OR = 1.07 per year; P < 0.001) and
rural (OR = 1.10 per year; P < 0.001) residents.
growth of obesity during recent years in Iran. Our findings indicate the
crucial necessity of primary prevention programs to counteract this
Obes Rev. 2010 May;11(5):335-7. Epub 2010 Feb 23.
Prevalence of Obesity and Overweight among Adults in
Ayatollahi SM, Ghoreshizadeh Z.
Department of Biostatistics, Medical School, Shiraz University of Medical
Science, Shiraz, Iran. firstname.lastname@example.org
The prevalence of overweight and obesity in most developed and
developing countries have been increasing markedly over the past two
decades. This increase includes all ages, genders, racial and ethnic groups,
income, and educational levels. This study examined the prevalence of
overweight and obesity among adults aged 25-55 years in Shiraz (Southern
Iran). The data are based on a random mul stage sample survey of 2282
married adults (1141 pairs) living is Shiraz, whose heights and weights were
measured in the 2002-2003 academic year. The prevalence of overweight
or obesity (body mass index > or = 25) was 49.7% in men and 63.9% in
women. The prevalence of obesity (body mass index > or = 30) was 10.5%
and 22.5% in men and women, respec vely, which shows an increased
secular change of 5.8% in men and 17.4% in women during a 14-year
period. Overweight and obesity are common in Iran. Obesity and
overweight were significantly more common among women than among
men (P-valve = 0.000). There is a need to establish programmes for
prevention and treatment of obesity especially Iranian's women.
Diabetes Res Clin Pract. 2010 Apr;88(1):117-24. Epub 2010 Jan 21.
Waist Circumference Has Heterogeneous Impact on
Development of Diabetes in Different Populations:
Longitudinal Comparative Study between Australia and
Rostambeigi N, Shaw JE, Atkins RC, Ghanbarian A, Cameron AJ, Forbes A,
Momenan A, Hadaegh F, Mirmiran P, Zimmet PZ, Azizi F, Tonkin AM.
Endocrine Research Unit, Mayo Clinic, Rochester, MN 55902, USA.
and diagnosis of metabolic syndrome (MS) in different populations.
METHODS: Population-based samples from Australia (n=9026) and Iran
(n=8259) were studied in 2000 and followed for approximately 4 years.
Follow-up a endance was approximately 58% and mean age was 51 vs. 47.
Pearson correlations calculated between WC and other MS components.
ROC for the role of WC in the prediction of incident diabetes was used.
54.5%), low HDL-C (35% vs. 11.2%), high triglyceride (52.2% vs. 29.6%) were
significantly higher in Iran. Fas ng glucose >or=5.6mmol/L was higher in
Australia (26% vs. 23%). Hypertension was no diﬀerent ( approximately
38%). Pearson correla ons between WC and other MS components were
stronger in Australians: FPG (0.32 vs. 0.2), HDL (0.47 vs. 0.16), TG (0.38 vs.
0.30) and SBP (0.38 vs. 0.36). Among women, area under ROC curve for WC
as a predictor for diabetes was signiﬁcantly higher for Australians (0.76 vs.
0.68, p<0.001) with no diﬀerence among men (0.69 vs. 0.71, p=0.4).
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