Breast Cancer (Auckl). 2011 Mar 1;5:27-35. Plasma
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Breast Cancer (Auckl). 2011 Mar 1;5:27-35.
Anthropometric Measures in Obese and Non-Obese
Women with Breast Cancer.
Rahmati-Yamchi M, Zarghami N, Rahbani M, Montazeri A.
Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University
of Medical Sciences, Tabriz, Iran.
INTRODUCTION: Expression of human telomerase reverse transcriptase
(hTERT) occurs in most cancers but its relation with obesity is unclear. This
study explores the association between leptin levels and anthropometric
indices with hTERT mRNA levels in breast cancer patients of different
patients participated. Expression of tissues hTERT mRNA was carried out by
real-time reverse transcription polymerase chain reaction. Leptin
concentrations were measured by enzyme-linked immunoassay.
RESULTS: Twelve pa ents (18.46%) were hTERT nega ve and 53(81.54%)
were positive. hTERT mRNA levels were associated with BMI but not with
waist circumference (WC) (r = 0.219, P = 0.22) and waist to hip ra o (WHR)
(r = 0.212, P = 0.237). Lep n level and hTERT mRNA levels (r = 0.484, P =
0.008) were correlated as well as BMI and hTERT expression.
and hTERT expression. These findings may clarify the role of leptin in breast
carcinogenesis, and hence obesity could be responsible for increased
incidences in breast cancer as well as its progression via enhanced
production of leptin.
Iranian Journal of Endocrinology and Metabolism (IJEM), 2010, 11(2): 177-
The Effect of Rhythmic Endurance Training on Abdominal
Obesity Indices among Working Women in Iran University
of Medical Sciences.
INTRODUCTION: Improvement of abdominal obesity indices in middle-
aged obese women by of exercise training has significant importance. The
aim of the study was to assess the effects of rhythmic Endurance training
on abdominal obesity indices (waist to hip ratio, waist circumference, waist
to high ratio, body fat %) in working women.
clinical trial conducted on, middle-aged women, aged >35 years, with
abdominal obesity, regular menstrual cycle, without regular exercising,
registered nurses & midwives, medicine, rehabilitation, para clinic, health
sciences university and all administrative departments of the Iran university
of Medical Sciences. Volunteer par cipants (n=31) were randomly
separated into cases (n=17) and controls (n=14). The case group has
Endurance training for 8 weeks. At the beginning and the end of the study,
in addi on to comple on of ques onnaires, anthropometrical data, VO2
Max determined by tape, calipers and a chronometer.
RESULTS: The results obtained showed that Endurance training had no
significant effect on waist-to-hip ratio in the cases, but significant positive
changes on waist circumference, waist-to-high ratio and body fat
percentage were seen.
CONCLUSION: Decrease in waist to hip ratio was not significant after
Endurance training, probably due to short dura on of exercise (8 weeks)
and also may be related to lack of diet control.
J Obes. 2011;2011:953410. Epub 2011 Mar 24.
Serum Resistin Level in Obese Male Children.
Amirhakimi A, Karamifar H, Moravej H, Amirhakimi G.
Department of Pediatrics, Namazee Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran.
OBJECTIVES: Resistin is a member of cysteine-rich molecules. Several
studies have been carried out to determine the biological effect of resistin,
nevertheless a significant number are animal studies. All the studies
performed regarding the relationship between serum resistin and obesity
were merely accomplished in women. To the best of our knowledge, there
is no survey on the correlation of the serum resistin level and obesity in
male children. The aim of the present study is to assess serum
concentration of resistin in obese male children.
METHODS: Between June 2009 and January 2010, we enrolled 42
randomly selected obese male students (body mass index (BMI) >95th
percen le, age 15.7 ± 1.5). Thirty-eight healthy age-matched male students
with normal BMI (<85th percen le) were selected as a control group for the
purpose of comparison of the serum resistin levels.
No signiﬁcant diﬀerence was found between resis n levels of the 2 groups
(obese: 9.21 ± 5.6 ng/mL versus normal: 9.83 ± 4.3 ng/mL; P = .582). There
was no significant correlation between serum resistin level and BMI.
Assessing the resistin level in male subjects was the distinct feature of our
study. The outstanding finding of this research is that there is no correlation
between serum resistin level and obesity.
obesity in male children and resistin level. Consequently, metabolic
abnormalities of insulin resistance seen in obese male patients are not
related to resistin.
Iranian Journal of Otorhinolaryngology No.2, Vol. 23, Serial No.63, Spring-
An Examination of Pre/Post-Adenotonsillectomy Obesity
Indices in 3-10 Year Old Children in Mashad, Iran
Mohsen Nematy1, Neda Shalaey2, Seyed Amir Reza Mohajeri3, Vahid
Ghorbani4, Mohammad Safarian5, *Mohammad-Reza Shariﬁan6
1 Biochemistry and Nutrition Research Center and Department of Nutrition,
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Nutrition, Faculty of Medicine, Mashhad University of
Medical Sciences, Mashhad, Iran
3 Department of Nutrition, Faculty of Medicine, Mashhad University of
Medical Sciences, Mashhad, Iran
4 Department of otorhinolaryngology, Faculty of Medicine, Mashhad
University of Medical Sciences, Mashhad, Iran
5 Biochemistry and Nutrition Research Center and Department of Nutrition,
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6 Ear, Nose, Throat, Head and Neck surgery Research Center, Mashhad
University of Medical Sciences, Mashhad, Iran
operations on children, which may result in weight gain in a number ways,
for instance, by increasing IGF-1 or decreasing respiratory hyperac vity.
group, conducted on ﬁ y 3-10-year-old children who had undergone
adenotonsillectomy and on fifty children as the control group. The
intervention and control groups were identical in terms of age and sex.
Height, weight, mid-arm muscle circumference, waist circumference, and
percent body fat measures were performed on the intervention group
before and six months after the surgery. The same measurements were also
performed on the control group at zero time and six months later.
Ultimately, the results were examined and compared.
intervention group showed a significant change after six months, with P
values of 0.002 and 0.024 respec vely. There were no signiﬁcant
correlations for other variables.
CONCLUSION: Based on the findings of this study, children who had
undergone adenotonsillectomy for various indications showed a gradual
postoperative increase in their BMI and percent body fat.
Metab Syndr Relat Disord. 2011 Feb;9(1):41-7. Epub 2010 Nov 5.
Predictors Of Serum Levels Of High Sensitivity C-Reactive
Protein And Systolic Blood Pressure In Overweight And
Obese Nondiabetic Women In Tehran: A Cross-Sectional
Neyestani TR, Salekzamani S, Kalayi A, Alavi-Majd H, Houshiarrad A,
Nikooyeh B, Shariatzadeh N.
National Research Institute and Faculty of Nutrition and Food Technology,
Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
OBJECTIVE: Extra fat mass is usually accompanied by metabolic as well as
clinical derangements, including systemic inflammation and high blood
pressure. This study aimed to evaluate the associations among
anthropometric indicators, blood levels of high-sensitivity C-reactive
protein (hsCRP), lipid profile, blood glucose, insulin resistance, and blood
pressure and determine the actual predictors of hsCRP and blood pressure
in overweight/obese nondiabetic women in Tehran.
(BMI) of ≥25 kg/m² were enrolled in a cross-sectional study. Dietary intake
and anthropometric as well as laboratory evaluations, including fasting
plasma glucose (FPG), lipid profile, serum insulin, and hsCRP, were
performed for all the subjects. Pearson (r) and Spearman (r(s)) correlation
coefficients and multivariate linear regression analysis were used to
establish a model to predict hsCRP and systolic blood pressure (SBP)
RESULTS: Although serum hsCRP directly correlated with levels of FPG,
triglycerides (TG), total cholesterol, BMI, and waist circumference (WC), its
strongest association was found with percent of body fat mass (FM)
(r(s) = 0.326, p < 0.001). Also, SBP directly correlated with FPG, TG, and
FM, but it was more strongly correlated with BMI (r = 0.343, p < 0.001)
and WC (r(s) = 0.350, p < 0.001). No associa on was found between
blood or anthropometric variables and dietary data. In different regression
models, WC and FM were the predictors of hsCRP, but BMI was the
significant predictor of SBP.
inflammatory biomarkers and SBP, thus predisposing for metabolic
syndrome and further morbidities. We identified FM and WC as the
predictors of serum hsCRP levels and BMI as the predictor of SBP in our
East Mediterr Health J. 2011 Feb;17(2):109-14.
Prevalence of Overweight and Obesity and Associated
Risk Factors in Urban Primary-School Children in Babol,
Islamic Republic of Iran.
Hajian-Tilaki KO, Sajjadi P, Razavi A.
Department of Social Medicine and Health, Babol Faculty of Medicine,
Babol University of Medical Sciences, Babol, Islamic Republic of Iran.
Childhood obesity is a major public health problem globally because of
changes in lifestyles. We assessed the prevalence of overweight/obesity
and associated factors in urban schoolchildren in Babol in a cross-sectional
study of 1000 schoolchildren aged 7-12 years. Weight and height were
measured and data on sports activities and leisure time physical activities
were collected by questionnaire. Overweight/obesity were assessed by
comparing body mass index (BMI) values to the BMI index for age and sex
percentiles set by CDC, Atlanta. The prevalence of obesity and overweight
was 5-8% and 12.3% respec vely. The prevalence was signiﬁcantly lower in
girls compared with boys (age-adjusted OR = 0.69, 95% Cl: 0.50-0.96) and
higher among private-school educated children compared with public-
school educated students (age adjusted OR = 2.17, 95% Cl: 1.47-3.18). For
each additional score of leisure time physical activity, the age-adjusted OR
Diabetes Res Clin Pract. 2011 Feb;91(2):154-8. Epub 2010 Nov 30.
Serum Visfa n is Associated With Type 2 Diabetes
Mellitus Independent of Insulin Resistance and Obesity.
Esteghamati A, Alamdari A, Zandieh A, Elahi S, Khalilzadeh O, Nakhjavani M,
Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School
of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
OBJECTIVE: The aim of this study was to evaluate the association of serum
visfa n, adiponec n and lep n with 2 diabetes mellitus (T2DM) in the
context of the role of obesity or insulin resistance, which is not well
METHODS: A total of 76 newly-diagnosed T2DM pa ents and 76 healthy
control subjects, matched for age, body mass index (BMI) and sex ratio,
were enrolled. Anthropometric parameters, glycemic and lipid profile,
insulin resistance (measured by homeostasis model assessment of insulin
resistance index [HOMA-IR]), leptin, adiponectin, and visfatin were
RESULTS: On the contrary to adiponectin, serum leptin and visfatin levels
were higher in T2DM pa ents compared with controls (10.07 ± 4.5, 15.87 ±
16.4, and 5.49 ± 2.4 vs. 12.22 ± 4.9 μg/ml, 8.5 ± 7.8 ng/ml and 3.58 ± 2.2
ng/ml, respec vely, P<0.01). Waist circumference and BMI were correlated
with leptin and adiponectin but not with visfatin. Leptin, adiponectin and
visfatin all were associated with T2DM following adjus ng for obesity
measures. After controlling for HOMA-IR, visfatin remained as an
independent predictor of T2DM (odds ra o=1.32, P<0.05). In a mul ple
regression analysis to determine visfatin only triglycerides and fasting
glucose remained in the model (P<0.05).
CONCLUSION: Eleva on of visfa n in T2DM is independent of obesity and
insulin resistance and is mainly determined by fasting glucose and
Public Health Nutr. 2011 Jan;14(1):62-9. Epub 2010 Mar 31.
Dietary Diversity Score is related to Obesity and
Abdominal Adiposity among Iranian Female Youth.
Azadbakht L, Esmaillzadeh A.
Department of Nutrition, School of Public Health, Isfahan University of
OBJECTIVE: To assess the relationship between diet and disease,
consideration of whole-diet indices may be more informative than single-
nutrient intake. The present study was conducted to report the relationship
among dietary diversity score (DDS), obesity and abdominal adiposity
among female university students.
18-28 years was selected randomly from Isfahan University of Medical
Sciences, Iran. Usual dietary intake was assessed using a validated semi-
quantitative FFQ. DDS was calculated according to the scoring of the five
food groups based on the US Department of Agriculture Food Guide
Pyramid. This is a score of diet variety, and shows the diversity of the
consumed diet. Participants were categorised on the basis of quartile cut-
off points of DDS. Potential confounders such as age, total energy intake
and physical activity were considered in all the analyses.
kg/m2 and 85·5 (sd 14) cm, respec vely. The probability of obesity
decreased with quar les of DDS (OR among quar les: 1.00, 0.41, 0.31 and
0.21, P = 0.03; this was the same for abdominal adiposity: 1.00, 0.55, 0.36
and 0.21, P = 0.02). Those in the lowest quar le of the DDS had the highest
risk for being overweight.
CONCLUSIONS: There were inverse associations among DDS, obesity and
abdominal adiposity among the female students of Isfahan University.
Further prospective investigations are needed to confirm this finding.
Ital J Pediatr. 2011 Jan 6;37:1.
Relationship between Obesity and Asthma Symptoms
among Children in Ahvaz, Iran: A Cross Sectional Study.
Kajbaf TZ, Asar S, Alipoor MR.
Pediatric Department, Abuzar Children's Hospital, Ahvaz Jondishapour
University of Medical Sciences, Golestan street, Ahvaz, Iran.
prevalence of asthma and asthma-related symptoms in children. The
objective of this study was to evaluate the relationship between the
prevalence of asthma symptoms and obesity among school-age children in
the city of Ahvaz, Iran.
this study through cluster sampling. The International Study of Asthma and
Allergies in Childhood (ISAAC) questionnaire was used to identify the
children who were currently suffering from asthma. Height and weight
were measured and body mass index (BMI) was calculated in kg/m2.
Overweight was defined as BMI greater than the age- and sex-speciﬁc 85th
percen le, and obesity as BMI greater than the 95th percen le. We
determined the relationship between obesity and asthma symptoms by chi-
overweight was 21.56%, 8.7%, 6.87%, and 9.5%, respec vely. The current
prevalence of wheezing among obese and overweight children was 68.75%
and 37%, respec vely, and there was a sta s cal associa on between
obesity and the prevalence of current wheezing (p < 0.001), night cough (p
rhinoconjunctivitis, so it seems that the pathophysiology of asthma in obese
and overweight children is not related to allergy.
and both overweight and obesity in both sexes among school-age children.
Iranian Journal of Public Health, 2011;40(2) : 96-101
The Relationship between Obesity and Quality Of Life in
, *F Alhani
, A Kazemnejad
, Z Khodaverdi
F Alhani: E-mail: email@example.com
Dept. of Physical Education, Faculty of Human sciences, Payame Noor
Dept. of Nursing, Faculty of Medicine, Tarbait Modares University, Tehran,
Dept. of Biostatistics, Faculty of Medicine, Tarbait Modares University,
Dept. of Motor behavior, Faculty of Human sciences, Tarbiat Moallem
University, Tehran, Iran
of life and body mass index in children aged 9-11 years old.
METHODS: This cross sec onal study was conducted on 240 children 9-11
year olds who were selected via multi stage cluster sampling design from
primary schools in the Shahre Qods of the Tehran, Iran in 2007. Pediatric
Quality of Life inventory was completed by child self report with measured
height and weight used to determine body mass index percentile/weight
classification. Obesity was defined as body mass index (BMI) ≥95
was used for data analyses.
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