The Role of stem cells in human development and potential for treating disease. The Role of stem cells in human development and potential for treating disease


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The Role of stem cells in human development and potential for treating disease.

  • The Role of stem cells in human development and potential for treating disease.

  • Prerequisite Humbio 2A,B or consent of instructor

  • Prof. Margaret Fuller and Roeland Nusse

  • Guest Speakers: Hank Greely, Stefan Heller, David Magnus, Anthony Oro, Theo Palmer, Thomas Rando, Renee Reijo Pera, Irving Weissman, Marius Wernig, Joanna Wysocka

  • Offered next year.















HOW TO DIRECT DIFFERENTIATION OF CELLS DOWN SPECIFIC PATHWAYS? e.g. all into muscle or all into nerve; different “cocktails” of growth factors

  • HOW TO DIRECT DIFFERENTIATION OF CELLS DOWN SPECIFIC PATHWAYS? e.g. all into muscle or all into nerve; different “cocktails” of growth factors

  • HOW TO OVERCOME IMMUNE REJECTION? e.g. alter histocompatibility genes; therapeutic cloning for “customized” lines

  • HOW TO MAKE AN ORGAN? e.g. combine different cell types in three dimensional arrangements.





































Hans Clever’s annimations

  • Hans Clever’s annimations







Adult rat contains 6x1010 cells

  • Adult rat contains 6x1010 cells

  • In its small intestine, a rat sheds over 1013 epithelial cells during its lifetime.

  • Requires 103 symmetric cell doublings from embryo to adult followed by 1013 asymmetric cell doublings during its lifetime

  • How do epithelial cells minimize mutations that lead to cancer?































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