Bank of Krok testing to module N1


Bank of Krok testing to module N3


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20150829-211235

Bank of Krok testing to module N3
Virology : general points
* For virus indication into cell culture a method is used that based onto changes of pH of culture medium during cultivation viruses in vitro. What is the name of this virus indication method?
*Color test
Cytopathic effect
Hemagglutination test
Hemadsorption
Plaque formation

*For vaccine preparation microbial cultures are propagated onto artificial nutrient media. Which microorganisms do not grow into artificial nutrient media?


*Viruses
Fungi
Actynomyces
Protozoa
Micoplasma

*A sample from patient with diagnosis “Influenza” was sent to laboratory. During virological investigation hemadsorption test has been used. Which viruses can be revealed with this test?


All of naked viruses
All of enveloped viruses
*Viruses possessing hemagglutinins on their surface
DNA-including viruses
Any virus

* During virological investigation of a sample, collected from patient A., 15 year old, with suspicious infectious mononucleosis, Epstein-Barr virus (EBV) was revealed. Which order of DNA-including viruses replication into the host cell is correct?


*Deproteinization, transcription, protein synthesis, virus DNA synthesis
Deproteinization, protein synthesis, transcription, virus DNA synthesis
Transcription, protein synthesis, deproteinization, virus DNA synthesis
Protein synthesis, deproteinization, transcription,, virus DNA synthesis
No one

* Papilloma virus, the 16th type, was revealed with PCR in a patient with cervical malignancy. It is known, this virus integrates own DNA with host genome. What is the name of virus integrated with cell genome?


*Provirus
Viroid
Virusoid
Virion
Prion

* A sample from patient with diagnosis “ARVI” was sent to laboratory for virological investigation. What is purpose of virus typing isolated from patient’s sample?


*Etiological diagnostics of virus infection
To study biological properties of viruses
To study physico-chemical properties of viruses
Development of non-specific prevention measures
To study virus resistance to environmental factors action

*A child, 1.5 year-old, had been suspected with adenovirus infection by physician. With CFT antibody titer to adenovirus in patient serum was revealed as 1:20. During recovery (after 2 weeks) serology was repeated. Which result confirms previous diagnosis?


Decreasing of antibody titer
*Increasing of antibody titer
The same titer of antibody
Negative result of CFT
Uncomplete antibody revealing

*To confirm diagnosis of acute respiratory virus infection with laboratory methods a doctor decided to use serological method of diagnostics. Which way should material be collected for this investigation?


*At onset of disease (as early as possible) and after 2-3 weeks
At onset of disease (as early as possible)
At the end of disease, in period of symptoms fading
At peak of disease, when all clinical symptoms are bright
At maximal data of body temperature

* A district doctor recommended interferone usage to prevent influenza. What is mechanism of action of this preparation?


Damage maturation of a virus
Inhibition of virus releasing from cell
*Blockage of translation initiation and destruction virus-specific m-RNA
Blockage of virus deproteinization
Inhibition of virus adsorption onto cell receptors

Phages
* For prevention of post-surgery complication abdominal cavity of patient was inoculated with 50 ml of liquid polyvalent staphylococcal phage. What is mechanism of this drug action?


*Lyses of microbial cells
Neutralization of staphylococcal toxins
Immunity activation
Inhibition of causative agent growth
Disorder of virulent enzymes biosynthesis

A child, 8 month old, has intestinal disorders. Qualitative and quantitative assay of intestinal microbiota revealed disbiosis. Coli-proteus bacteriophage is administered for treatment. What is mechanism of this drug action?


*Cause lyses of opportunistic enterobacteria
Promotion multiplication of Bifidibacteria
Enhance antagonistic effect of Lactobacilli
Stimulate synthesis of secretory IgA
Intencify barrier properties of intestinal mucous membrane

* For gene-ingeneering insulin production a strain of E.coli was created, that includes gene determining synthesis of this hormone. It is the most reasonable in strain-producer creation to use vector which causes destruction of E.coli cell after task is made. Which kind of genetic structure is this?


Plasmids
*Bacteriophage
Isolated DNA-fragment
Isolated RNA-fragment
Transposon

Special virology: HIV


182. It is known that human immunodeficiency virus belongs to Retroviridae family. What basic feature characterizes this family?


A. Simple viruses, which affect only human beings.
B. Contain RNA of negative polarity.
C. *Presence of reverse transcriptase enzyme.
D.Nucleic acid does not integrate into the genome of the host.
E. DNA-containing viruses which cause chronic infections.

*08* It was revealed that T-lymphocytes were affected by HIV. Virus enzyme – reverse transcriptase (RNA-dependent DNA-polymerase) – catalyze the synthesis of:



  1. Viral DNA on DNA matrix

  2. DNA on virus ribosomal RNA

  3. Virus informational RNA (m-RNA) on the matrix of DNA

  4. mRNA on the matrix of virus protein

  5. *DNA on the matrix of virus mRNA

Rather often the cause of acquired immunodeficiency is the infectious damage of organism which is characterized by causative agents' reproduction directly in immune system cells and destruction of these cells. Choose such disease among given below.


A. *AIDS.
B.Diphtheria.
C.Poliomyelitis.
D. Cholera.
E.Epidemic typhus

OB-12 Quite often the cause of secondary immunodeficiency is an infection involvement, when the causative agents propagate directly in the cells of immune system and destroy it. The following diseases are characterized by:



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