Dario Conte, M. D. Gastroenterology and Endoscopy Unit


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  • Aim: normal values definition









Diagnostic Case Control Study

  • Diagnostic Case Control Study

  • Test

  • threshold

  • Healthy

  • volunteers



















Intestinal lymphangectasia and reversible high liver stiffness

  • Intestinal lymphangectasia and reversible high liver stiffness







Diagnosis of cirrhosis by transient elastography (Fibroscan): a

  • Diagnosis of cirrhosis by transient elastography (Fibroscan): a

  • prospective study

  • TE in 711 patients with CLD of different etiology (354 with liver biopsy)

  • Foucher et al. Gut 2006











In the assessment of liver fibrosis an RCT compared the

  • In the assessment of liver fibrosis an RCT compared the

  • accuracy of two different biopsy needles (Tru cut vs

  • Menghini) in the diagnosis of liver cirrhosis:

  • 1.192 patients were randomized to one of the two needles

  • and a significant difference in diagnostic accuracy was found

  • Colombo et al. Gastroenterology 1988





Liver stiffness measurement (LSM) is an accurate test for liver cirrhosis

  • Liver stiffness measurement (LSM) is an accurate test for liver cirrhosis

  • Ideal study: to estimate the cumulative incidence of FN patients randomizing patients with suspected cirrhosis to LSM or liver biopsy

  • Patients classified as cirrhotics should undergo endoscopy

  • The comparison of the negative results could identify the safer procedure











  • RCT

  • Large cohorts study

  • To assess in case of discordance between the IT and RS results what are the right results and

  • The proportion of patients with rare adverse events from the diagnostic test-therapeutic strategy




















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