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Document Outline - Cover Page
- Title Page
- ISBN 9781555814984
- Contents
- Preface
- Preface to the First Edition
- PART I: FUNDAMENTALS OF MOLECULAR BIOTECHNOLOGY
- Chapter 1 The Development of Molecular Biotechnology
- The Emergence of Molecular Biotechnology
- Recombinant DNA Technology
- Commercialization of Molecular Biotechnology
- Concerns and Consequences
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 2 DNA, RNA, And Protein Synthesis
- Structure of DNa
- DNA Replication
- Decoding Genetic Information: RNA and Protein
- Translation
- Regulation of mRNA Transcription in Bacteria
- Regulation of mRNA transcription in Eukaryotes
- Protein Secretion Pathways
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 3 Recombinant DNA technology
- Restriction Endonucleases
- Plasmid Cloning Vectors
- Creating and Screening a Library
- Cloning DNA Sequences that Encode Eukaryotic Proteins
- Vectors for Cloning Large Pieces of DNA
- Genetic Transformation of Prokaryotes
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 4 Chemical Synthesis, Amplification, and Sequencing of DNA
- Chemical Synthesis of DNA
- Polymerase Chain Reaction
- DNA-Sequencing Techniques
- Large-Scale DNA Sequencing
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 5 Bioinformatics, Genomics, and Proteomics
- Molecular Databases
- Metagenomics
- Functional Genomics
- Proteomics
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 6 Manipulation of Gene Expression in Prokaryotes
- Gene Expression From Strong and Regulatable Promoters
- Fusion Proteins
- Translation Expression Vectors
- Increasing Protein Stability
- Overcoming Oxygen Limitation
- Limiting Biofilm Formation
- DNA Integration into the Host Chromosome
- Increasing Secretion
- Metabolic Load
- SUMMARY
- REFERENCE
- REVIEW QUESTIONS
- Chapter 7 Heterologous Protein Production in Eukaryotic Cells
- Posttranslational Modification of Eukaryotic Proteins
- General Features of Eukaryotic Expression Systems
- Fungus-Based Expression Systems
- Baculovirus–Insect Cell Expression Systems
- Mammalian Cell Expression Systems
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 8 Directed Mutagenesis and Protein Engineering
- Directed Mutagenesis Procedures
- Protein Engineering
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- PART II: MOLECULAR BIOTECHNOLOGY OF MICROBIAL SYSTEMS
- Chapter 9 Molecular Diagnostics
- Immunological Diagnostic Procedures
- Monoclonal Antibodies
- Biofluorescent and Bioluminescent Systems
- Nucleic Acid Diagnostic Systems
- Molecular Diagnosis of Genetic Disease
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 10 Protein Therapeutics
- Pharmaceuticals
- Enzymes
- Lactic Acid Bacteria
- Monoclonal Antibodies
- Recombinant Antibodies
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 11 Nucleic Acids as Therapeutic Agents
- Antisense RNA
- Ribozymes
- Chimeric RNA–DNA Molecules
- Aptamers
- Interfering RNAs
- Antibody Genes
- Nucleic Acid Delivery
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 12 Vaccines
- Subunit Vaccines
- Peptide Vaccines
- Genetic Immunization: DNA Vaccines
- Attenuated Vaccines
- Vector Vaccines
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 13 Synthesis of Commercial Products by Recombinant Microorganisms
- Restriction Endonucleases
- Lipase
- Small Biological Molecules
- Antibiotics
- Biopolymers
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 14 Bioremediation and Biomass Utilization
- Microbial Degradation of Xenobiotics
- Genetic Engineering of Biodegradative Pathways
- Utilization of Starch and Sugars
- Utilization of Cellulose
- Hydrogen Production
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 15 Plant Growth-promoting Bacteria
- Growth Promotion by free-Living Bacteria
- Biocontrol of Pathogens
- Nitrogen Fixation
- Hydrogenase
- Nodulation
- Phytoremediation
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 16 Microbial Insecticides
- Insecticidal Toxin of B. Thuringiensis
- Engineering of B. Thuringiensis Toxin Genes
- Baculoviruses as Biocontrol Agents
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 17 Large-Scale Production of Proteins From Recombinant Microorganisms
- Principles of Microbial Growth
- Maximizing the Efficiency of the Fermentation Process
- Bioreactors
- Typical Large-Scale Fermentation Systems
- Harvesting Microbial Cells
- Disrupting Microbial Cells
- Downstream Processing
- Large-Scale Production of Plasmid DNA
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- PART III: MOLECULAR BIOTECHNOLOGY OF EUKARYOTIC SYSTEMS
- Chapter 18 Genetic Engineering of Plants: Methodology
- Plant Transformation with the Ti Plasmid of A. Tumefaciens
- Ti Plasmid-Derived Vector Systems
- Physical Methods of Transferring Genes to Plants
- Chloroplast Engineering
- Use of Reporter Genes in Transformed Plant Cells
- Manipulation of Gene Expression in Plants
- Production of Marker-free Transgenic Plants
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 19 Engineering Plants to Overcome Biotic and Abiotic Stress
- Insect Resistance
- Virus Resistance
- Herbicide Resistance
- Fungus and Bacterium Resistance
- Oxidative Stress
- Salt and Drought Stress
- Fruit Ripening and Flower Wilting
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 20 Engineering Plant Quality and Proteins
- Modification of Plant Nutritional Content
- Modification of Food Plant Taste and Appearance
- Genetic Manipulation of Flower Pigmentation
- Plants as Bioreactors
- Edible Vaccines
- Plant Yield
- Phytoremediation
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 21 Transgenic Animals
- Transgenic Mice: Methodology
- Transgenic Mice: Applications
- Cloning Livestock by Nuclear Transfer
- Transgenic Livestock
- Transgenic Poultry
- Transgenic Fish
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- PART IV: MOLECULAR BIOTECHNOLOGY AND SOCIETY
- Chapter 22 Regulating the use of Biotechnology
- Regulating Recombinant DNA Technology
- Deliberate Release of Genetically Modified Microorganisms
- Regulating Food and Food Ingredients
- Patenting Biotechnology
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Chapter 23 Societal Issues in Biotechnology
- Concerns About the Safety of Consuming Genetically Modified Foods
- Concerns About the Impact of Genetically Modified Organisms on the Environment
- Economic Issues
- SUMMARY
- REFERENCES
- REVIEW QUESTIONS
- Amino Acids of Proteins and Their Designations
- Glossary
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- Index
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