Опухоли lethal (2) giant larvae

Genetic and Epigenetic Pathways of Tumor Supressor
lethal (2) giant larvae of Drosophila melanogaster
N. Ya. Weisman
 
*
Federal research Center Institute of Cytology and Genetics SB RAS, Prospekt Lavrent’eva 10, Novosibirsk, Russia, 630090
*e-mail: [e-mail]
Tumor suppressors are fundamental genes of development and they are highly pleiotropiс. Recessive muta-
tions of suppressor l(2)gl of drosophila are followed with composite phenotypical syndromes. Functions of
locus l(2)gl are carried out on genetic and epigenetic pathways. Protein Lgl in composite molecular complexes
regulates polarization of epithelial and nervous stem cells. Degree of activity l(2)gl in regulation of early de-
velopment, longevity, stress response, tumor development is dependent on level of microRNA expression, in-
tracellular bacterium, mutations of other vital genes and different external inf luences.
Keywords: tumor supressor, microRNA, cell polarity, longevity, epigenetics.