crease in the morphofunctional activity o f basophilic adenocytes.
Conclusion. Daily oral administration of Ladyginozid at a dose of 0.002 g/kg of animal weight caus
es an increase in the morphofunctional state of basophilic adenocytes of the pituitary gland, indicating, with
a high degree of probability, that basophilic cells of the adenohypophysis take part in the realization of the
hypolipidemic and anti-atherosclerotic effects of Ladyginozid.
175
ASSOCIATION OF BIOCHEMICAL AND TP53 GENE RS17884159
POLYMORPHISM IN THE DEVELOPMENT OF BREAST CANCER
Avezov N.Sh.1, Qodirova D.A.2, Maksudova A.N.4, Shertaev M.M.5,
Khudoyberdieva N.V.5, Boboev K.T.3
1 Institute o f Bioorganic Chemistry named after Obid Sodiqov,
2Institute o f Biophysics and Biochemistry at the National University o f Uzbekistan
named after M. Ulugbek,
3Republican Specialized Scientific-Practical Medical Center o f Hematology o f the Ministry o f Health o f
the Republic o f Uzbekistan,
4Tashkent Pharmaceutical Institute,
5Tashkent Pediatric Medical Institute
nodir-ibh@mail.ru
The breast cancer is the leading cause of cancer in women, meaning that one in four women diag
nosed with cancer in the world is breast cancer. In Uzbekistan, 24.6% o f cancer cases registered in the same
year, among women, breast cancer is noted. For this reason, the breast cancer in Uzbekistan requires the use
of new modern innovative technologies in the prevention and treatment. To conduct numerous researches
on the examination o f candidate genes that cause a large number o f somatic mutations in humans and sin
gle nucleotide polymorphisms, including those related to the development o f breast cancer. One o f these
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