Сборник V международной

The results obtained. Since the analyzed sample is of plant origin, stability was studied by the 
method of long-term storage in natural conditions. The liquid extract «Extradent» consists o f herbs of 
peppercorn (Polygonum hidropiper L.), shepherd’s purse (Bursa pastoris), calendula flowers (Calendulae 
officinalis) and nettle leaves (Urtica dioica L.). The composition and ratio of the composition is selected 
taking into account pharmacological screening. Liquid extract «Extradent» has a wide anti-inflammatory 
and antimicrobial spectrum of action, due to the content of flavonoids (quercetin, isoramnetin, rutin, luthio- 
lin, hyperoside), vitamins B, C, K, polysaccharides and terpenoids, so their content was determined during 
the stability studies.
The test samples were placed in dark glass vials with lapped stoppers. Quality control was carried 
out every quarter. Description: green liquid with a fragrant smell, bitter-astringent taste. Authenticity was 
determined by the High performance liquid chromatography method. Dry residue is not less than 1,5%, 
corresponds to, density from 0,9091 g/ to 0,9197 g/ , alcohol content is not less than 64%, heavy metals are 
not more than 0,01%. The quantitative content was determined by HPLC, flavonoid robinin - 0,37%, rutin 
0,01%, quercetin 0,0045% were determined.
The results obtained in the course of the conducted studies comply with the established standards.
Conclusions: The expiration date was established by the method of long-term storage in natural 
conditions. It was found that the expiration date was 2 years.
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF 
HYALURONIC ACID IN MEDICINAL PRODUCTS
Khamidov Sh.A., Smanova Z.A.
Mirzo Ulugbek National University o f Uzbekistan 
e-mail: [e-mail]; тел.[phone]
Relevance. Today, in the world, chemical aspects in the pharmaceutical industry are o f paramount 
importance, both in the production o f medicines and in the process o f quality control o f intermediate and 
finished products, as well as during the input control o f raw materials and materials. Therefore, there is 
an increasing need to find alternative, the most advanced, new physico-chemical methods for determining 
substances in medicines to assess their quality. The development o f the simplest, most accessible, express, 
reliable, universal, budgetary methods o f analysis is of great practical importance and is relevant.