Title: Benzotriazole and Tolyltriazole. Evaluation of health hazards and proposal of health based quality criteria for soil and drinking water Author


Download 202.46 Kb.
Pdf ko'rish
bet4/12
Sana28.12.2022
Hajmi202.46 Kb.
#1023995
1   2   3   4   5   6   7   8   9   ...   12
Bog'liq
978-87-93026-81-0(1)

4.1.3 Dermal contact 
4.1.3.1 Benzotriazole 
Five female rabbits received a single application of 2000 mg/kg to the clipped skin 
for 24 hours. No mortality was observed. Gross necropsy findings were not 
reported. (Sherwin-Williams Co. 1976 - quoted from BIBRA 1995; EPA/OTS 
1989 - quoted from TOXLINE pre 1982- 1990). 
4.1.3.2 Tolyltriazole 
The LD
50
-value reported for tolyltriazole (24 hours, covered contact) for rabbits 
was > 2000 mg/kg b.w. The LD
50
-value for 5-methylbenzotriazole (24 hours, 
covered contact) for guinea-pigs was reported to be > 1000 mg/kg b.w. (TNO 
BIBRA 1998). 
12


4.2 Irritation 
4.2.1 Skin irritation 
4.2.1.1 Benzotriazole 
Signs of skin irritation were seen in three out of five rabbits following a 24-hour 
covered contact with 2000 mg/kg b.w. to abraded skin [enheden (mg/kg b.w.) er 
korrekt citeret]. No irritation was reported after 72 hours when about 80 mg/cm
2
was applied to the intact or abraded skin of 12 rabbits and covered for 24 hours. 
(Sherwin-Williams Co. 1976 - quoted from BIBRA 1995). 
Benzotriazole was mildly irritating to guinea pigs at a concentration of 50% in 
ethanol (McAlack 1974 - quoted from BIBRA 1995). 
4.2.1.2 Tolyltriazole 
Covered 24-hour application of neat tolyltriazole to abraded rabbit skin caused 
slight skin redness in three of five animals; however, in a similar test, no irritation 
was noted in a further six animals. No redness or swelling was evident following 
similar exposure of intact skin (5-6 rabbits/ group) (Sherwin-Williams 1972a, 
1972b - quoted from TNO BIBRA 1998). 
Covered 24-hour contact with a 40% aqueous paste caused slight swelling of 
abraded skin and redness of the intact and abraded skin of four rabbits (it is not 
clear whether tolyltriazole or 5-methylbenzotriazole was applied in this study (Olin 
Mathieson 1968 - quoted from TNO BIBRA 1998).
An industrial grade (no further details given) of neat 5-methylbenzotriazole was 
irritating to rabbits given a 24-hour covered patch (Olin corp. 1973 - quoted from 
TNO BIBRA 1998). 
In guinea pigs, slight skin irritation was observed with 24-hour covered exposure to 
neat 5-methylbenzotriazole (Eastman Kodak 1975 - quoted from TNO BIBRA 
1998).
No skin reactions were seen when ten guinea pigs were given a 24-hour covered 
patch test with 10% tolyltriazole in petrolatum (Ciba Geigy 1982a - quoted from 
TNO BIBRA 1998).

Download 202.46 Kb.

Do'stlaringiz bilan baham:
1   2   3   4   5   6   7   8   9   ...   12




Ma'lumotlar bazasi mualliflik huquqi bilan himoyalangan ©fayllar.org 2024
ma'muriyatiga murojaat qiling