Dominios mac popularidad de mac: Aumento de visitas a practicantes de mac

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Dominios MAC

Popularidad de MAC: Aumento de visitas a practicantes de MAC

MAC: La evidencia

Dominios MAC

Mosto de St. John

  • Planta médicinal

  • Ampliamente usada

    • $6 billones de ventas europeas (1998)
    • $140 millones de ventas en EUA (1998)
  • Mezcla compleja de > 2 docenas de componentes

  • Constituyente antidepresivo = hiperforin

  • Interacciones medicamentosas

    • Anticonceptivos orales
    • Indinavir
    • Ciclosporina

Quimioprotección: Defensa contra toxinas

CYP3A causa inducción de interacciones medicamentosas

Superfamilia de receptores nucleares

PXR humano Modelo de expresión

PXR se une al promotor CYP3A

Mosto de St. John’s Wort Activates PXR

Mosto de St John regula otros genes objetivo PXR

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