International journal on human computing studies

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INTERNATIONAL JOURNAL ON HUMAN COMPUTING STUDIES 

www.journalsresearchparks.org/index.php/IJHCS 
e-ISSN: 2615-8159|p-ISSN: 2615-1898
 
Volume: 02 Issue: 6 November-December 2020 
 
© 2020, 
IJHCS
| Research Parks Publishing (IDEAS Lab) www.researchparks.org | Page 34 
 
INDICATOR OF DYSCIRCULATORY ENCEPHALOPATHY IN 
HYPOTHYROIDISM
 
 
Khayrullaeva Dilnora Khislatovna 
Assistant of the Department of Physiology of the
Bukhara State Medical Institute named after Abu Ali ibn Sino. 
 Uzbekistan 
 
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 Abstract -
In the scientific literature there are 
works devoted to the study of certain aspects of 
hemodynamics in hypothyroidism, but there is a lack of 
information about the features of cerebral circulation in 
conditions of deficiency of thyroid hormones. The aim of 
our study was to identify discirculatory encephalopathy 
and factors affecting its development in various forms of 
hypothyroidism. 
Keywords: Hypothyroidism, encephalopathy, 
hemodynamics, hypertension, syndrome Gofmana, 
Hashimoto disease. 
 
INTRODUCTION 
Patients with hypothyroidism in Uzbekistan is 
constantly growing. The greatest prevalence of 
hypothyroidism is observed in the age group of 
postmenopausal women, older than 50 years [1]. The 
clinical manifestation of endothelial dysfunction in 
patients with hypothyroidism is dyscirculatory 
encephalopathy (DE), a cerebral pathology that 
develops as a result of metabolic and vascular 
disorders [6, 7]. 
The study included 60 women aged 50-54 with a 
history of clinical and subclinical hypothyroidism. For 
all nosological units accompanied by hypothyroidism 
syndrome, an endocrinologist was required to identify 
neurological disorders. Thyroid status (TSH, SV. T4, SV. 
T3) was evaluated twice, at 6-month intervals. The 
determination of antibodies to TPO was mandatory in 
the study of the thyroid gland, since an increase in 
antibodies in patients to thyroperoxidase indicated a 
lesion of the Central nervous system [8]. 
Hypothyroidism in the main group of patients was 
caused by autoimmune thyroiditis. In order to detect 
hypertensive encephalopathy in all subjects, a blood 
PRESSURE study was conducted, and women with blood 
PRESSURE were included in the study 125+4,0 / 70+10 
in addition to the above, the neck vessels were 
examined 
by 
duplex 
scanning 
on 
the 
GeneralElectricVivid3.0 
device 
(GeneralElectricHealthcare, USA). 
Depending on the results obtained, all women 
included in the study were divided into 2 groups: group 
1-30 patients with subcompensated hypothyroidism 
(SG) (TSH>4.5 med/l, SV.T4 within the reference 
values) and group 2 - 30 patients with decompensated 
hypothyroidism (TSH is higher, and SV. T4 is lower than 
normal). The exclusion criteria were thyroid 
hyperfunction, a history of cancer, stroke, or heart 
attack. The studied women had subjective or objective 
weak cognitive impairments: decreased memory, 
attention and intelligence, lethargy, apathy, drowsiness, 
the degree of these disorders depended on the severity 
of the decrease in thyroid function. These symptoms 
were preceded by neuromuscular manifestations such 
as Hoffmann's syndrome, hypothyroid myopathy. These 
States were emotionally colored: against the 
background of shortness of breath, anxiety, 
unmotivated fears, and vital longing appeared. The 
difference between these States and panic attacks was 
their duration and stereotype. It should also be 
emphasized that the administration of novopassit did 
not reduce the frequency and duration of seizures, but 
the appointment of thyroid hormone replacement 
therapy helped to reduce neurological symptoms. 

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