Actual problems of modern science, education and training

Ключевые слова: кеторолак, сульфат меди, карбамид, комплексное соединение, металлокомплекс, рентгеноструктурный анализ, элементный анализ, антимикробный препарат, монокристаллы, анализ поверхности по Гиршфельду.
Introduction. The study of coordination compounds allows to explain their main chemical properties, to form complexes, to determine the nature of chemical bonds between ligands, to determine the mechanisms of processes involving coordination compounds and changes in the reactivity of coordinated ligands using modern physical research. The obtained information is important for purposefully finding and synthesizing new chemical substances with predetermined specific
characteristics, composition and structure, as well as other important properties. This is especially necessary for substances with biologically active properties used in medicine[3]. Together with the staff of our laboratory, we tried to obtain a metal complex compound of such a bioactive ligand ketorolac. Ketorolac has a pronounced analgesic effect, and is used as an anti-inflammatory and moderate antipyretic agent. Inflammation and fever appear due to the entry of various disease-causing bacteria into the human body from the external environment. Ketorolac is one of the non-steroid substances used to eliminate this process, and in order to strengthen its effect, biometals such as Cu, Mn, Co, Zn, Mo, Fe were selected from 3d-metals and a metallocomplex compound was synthesized. When these new metallocomplex compounds are poisoned by microbes, they bind to them and try to remove them from the body faster or completely lose their effect [4].
Aim of the research consists of developing a methodology for synthesizing a complex combination of Cu²⁺ ion with ketorolac and studying the composition and structure of the synthesized complex using modern physico-chemical research methods.
Literature review. Scientific research aimed at determining the synthesis of complex compounds of (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (as a compound with 2-amino-2-hydroxymethyl-1,3-propanediol) (Ketorolac), which is one of the aromatic carboxylic acid derivative, with biometals, their spatial structure, “bioactivity-structure” connection is being carried out in the world’s leading scientific centers and higher educational institutions, including Delhi Institute of Pharmaceutical Sciences and Research (India), Institute of Inorganic Chemistry of Aachen University (Germany), Institute of General and Inorganic Chemistry, Moscow State University (Russia), University of Tokyo (Japan), Royal Institute of London (England), Institute of Engineering and Technology (China), Jagiellonian University (Poland), Institute of General and Inorganic Chemistry (Uzbekistan) [ 5]
As a result of research conducted in the world on the structure of complexes of ketorolac with biometals and their biological activities, a number of scientific results were obtained, including the following: synthesis of chelated complexes of metals was carried out, their spatial structure and charge density were determined (Institute of Inorganic Chemistry of Aachen University, Germany); mixed-ligand coordination compounds involving carboxylates were synthesized (Institute of General and Inorganic Chemistry, Moscow State University, Russia); complexes based on biometals were synthesized, molecular and crystalline structures, as well as bioactivity were determined (Royal Institute of London, Great Britain); bi- and trihedral coordination compounds of ketorolac were obtained (Engineering-Technical Institute, China); complexes of metals with (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1- carboxylic acid derivatives were obtained and their mutual coordination types were determined (Jagiellonian University, Poland); on the basis of trace elements, cartbamide, ketorolac, drugs that leave pain in the human body and partially eliminate inflammation have been obtained and tested (Institute of General and Inorganic Chemistry, Uzbekistan). [6].
Scientific researches by Imanakunov B.I., Sulaymonkulov K.S., Tsivadze G.V., Tsintsadze G.V., Kharitonov Y.A., B.Kol, M.Kholt, Khamilton V.S., Kozlova
I.A., Savinkin Y.V., Kuzmin N.E., Palkin K.K., Penland R.B., Rau T.F., Dursun
A.K and others were devoted to the synthesis of complex compounds of 3d metals and ketorolac in solutions and the study of physico-chemical research methods in the world [7].
Leading scientists of our country Parpiev N.A., Khodjaev O.F., Khakimov Kh.Kh., Ibragimov B.T., Sharipov Kh.T., Azizov T.A., Azizov M.A., Kadirova Sh.K., Kadirova Z.Ch., Daminova Sh.Sh. and their students have synthesized a number of biologically active coordination compounds that are used in medicine and other areas of the national economy. The technology of obtaining complex compounds of various salts of metals with bioactive organic ligands was developed, the processes of formation of coordination compounds in solutions and solid phases were studied. The physicochemical properties of the synthesized compounds were analyzed. Despite the fact that there are many experimental materials on the study of complexes of metal salts with substances containing the carboxyl group and amino group, the synthesis of metallocomplexes of Cu²⁺ mixed with ketorolac from these 3d-metal salts in solution has not been studied. In addition, there is no information about the structure of the coordination knot of compounds of this class [8].