Research Methodology. In particular, the staff of our laboratory performed several reactions, trying to obtain complex combinations of the drug, known as a temporary pain reliever, 2-amino-2-hydroxymethyl-1,3-propanediol (Ketorolac) with 3d-metals and to strengthen the scope of action. The synthesis process was carried out as follows: aqueous solutions of 0.25 g (0.001 mol) of CuSO4·5H2O crystal hydrate salt and 0.510 g (0.002 mol) of ketorolac were prepared. At the first stage, in order to increase the reactivity of ketorolac, its sodium salt was obtained by reacting it with NaOH in a ratio of 1:1. At the second stage, ketorolac sodium salt and CuSO4·5H2O crystalline hydrate salt were mixed in a ratio of 2:1. Then, at the last stage, 1ml of the 0.1N solution of carbamide solution obtained as an auxiliary ligand was added dropwise to the complex salt solution. Then it was thoroughly mixed in a MS-H280- Pro magnetic stirrer at a temperature of 60°C for 40 minutes [9]. Then, the solution of the synthesized complex compound is left to slowly evaporate at room temperature. After five days, the obtained precipitates were filtered, washed with ethyl alcohol, then evaporated to a dry residue in a rotary evaporator at 60°C and dried. As a result, dark- green crystals of the complex compound were formed. The synthesis reaction can be expressed as follows:
OH ONa
NaOH H2O
Scheme 1: The reaction to obtain the sodium salt of ketorolac
ONa
CuSO4 5 H2O
2
O Cu
O
Na2SO4 5 H2O
O
H2N O
NH2 C O
O
Cu O
O C NH2 O NH2
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