Bank of Krok testing to module N1
A Previous hepatitis B B
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20150829-211235
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A Previous hepatitis B
B Acute hepatitis B C Acute hepatitis C D Chronic hepatitis В E Chronic hepatitis С *A man, 25-year-old, has fever and jaundice. There were not neither HBsAg nor antibody to HBs-antigen in the blood assay asked by doctor. Which from additional test, most probably, may confirm presence of hepatitis B infection? *HBeAG Antibody to HBeAg Antibody to HBcAg HBxAg Delta-antigen *2013* A patient M. complaining of fever, general weakness, and jaundice, was admitted to infectious department. A doctor suspected hepatitis B infection based onto event, that patient had hemotransfusion some months ago. What basic methods of laboratory diagnostics in case of hepatitis B are? *Serology and gene diagnostics Isolation of a virus into cell culture and identification due to CPE Virion detection in the blood at electron microscopy Isolation of a virus into chicken embryo Isolation of the virus in laboratory animals (neutralization test) *06* 185. The causative agent of hepatitis D (delta-agent) is a defective virus. It can replicate only in cells already infected with one of the viruses. Which one is possible with? A. Human immunodeficiency. B.Hepatitis A. C.Hepatitis E. D.Epstein-Barr. E. *Hepatitis B. 191. A patient with a very grave course of hepatitis B has been administered the examination for detecting the possible concomitant agent, which complicates the course of the basic disease. What agent is this? A.*Delta-virus. B.Hepatitis C virus. C.Hepatitis G virus. D.Hepatitis E virus. E.HBs-antigen. b-12 *01*, *02* 192. During an operative intervention (surgery) a patient had blood transfusion. In this blood the presence of the following causative agent should be checked: A.*Hepatitis B virus. B.Hepatitis A virus. C.Hepatitis E virus. D.Enteroviruses. E.Adenoviruses. *02* A patient with jandice has next result of laboratory assay: HBsAg -, HBeAg -, antiHBsG +, anti HBsМ-, HСAg+. Which diagnosis is confirmed on the base of these data? Hepatitis C Chronic hepatitis B with low replicative activity Repeated infection with hepatitis B *Hepatitis C, last hepatitis B Recurrence of hepatitis B *03* During examination of a donor, which has not being given blood for a long time, antiHBs-antibody was revealed with ELISA. What does positive result indicate in this case? About chronic hepatitis C About acute hepatitis C About chronic hepatitis B *about recovery after hepatitis B About acute hepatitis B Hepatitis A virus 76. A patient with viral hepatitis A was admitted to an infectious hospital. What antibodies will be synthesized first in response to this virus reproduction? A. IgA. B.IgG. C.*IgM. D. IgD. E. IgE. 188. In a settlement there is registered an outbreak of hepatitis associated with water factor. What virus could induce this outbreak? A.Hepatitis G. B.Hepatitis C. C.Hepatitis D. D.*Hepatitis A. E.Hepatitis B. * A month after returning from summer camp a child was hospitalized into infectious department. A doctor suspected hepatitis A infection based onto complaints. What is the most probable way of hepatitis A infection in this case? *Fecal-oral Via contact By inhalation of dust transmissive (via vector) Parenteral *07* A outbreak of hepatitis has been registered in region, that is connected with water factor. Which virus could cause this outbreak? Hepatitis G virus Hepatitis C virus Hepatitis D virus *Hepatitis A (E!) virus Hepatitis B virus Hepatitis E virus *A person with general weakness, subfebrility, icteritious sclera and skin visited a hospital. It is known from history, that he was at seaside and ate seafood without cooking 2 weeks ago. Which markers detection allows confirming diagnosis “acute hepatitis E”? *IgM anti-HEV IgM anti-HAV IgG anti-HEV IgG anti-HAV Poliovirus/enteroviruses 176. From a patient with acute intestinal infection enterovirus was obtained. To detect the serotype of the virus diagnostic sera were used. Which antibodies must the serums contain? A.To proteins of supercapsid. B.* To proteins of capsid. C.To non-structural virus proteins. D.To virus enzymes. E. To virus hemagglutinin. 198. For poliomyelitis serologic diagnostics paired serum samples of a patient are being examined. What should be used as antigen during virus neutralization test? A. Antigens of virus capsid proteins. B. Viral complement-fixing antigens. C. Antigens inactivated by formalin. D. Antigens-hemagglutinins. E. *Live viruses. * A patient M., after returning from India, was suspected as ill with poliomyelitis. What investigations should be done for confirmation of diagnosis? *Virus isolation from feces and its identification; serology of paired patient’s sera Indication of virus in feces with electron microscopy Blood microscopy with wet mount and hanging drop smears Investigation of lavage water of stomach with fluorescent antibody Inoculation of feces into enriched media 181. The first vaccination against poliomyelitis should be done at 3 month's age with the use of Sabin vaccine. What class of immunoglobulins does not take part in postvaccinal immunity formation in this case? A. IgG. B.*IgE. C. IgA secretory. D.IgM. E. IgA serum. For confirmation of diagnosis “Coxsackie B virus infection” a sample from patient H., 16-years-old, was sent to laboratory. What should be used for virus isolation? Endo medium Blood agar Chicken embrion Meat-peptone broth *Continuous cell lines (Hep-2, HeLa) *08* b-12 A culture of monkey cells (Vero) and a group of sucklings mouse were infected with an inoculum taken from a child with provisional diagnosis “enterovirus infection”. There was no cytopathic effect on the cell culture, but suckling mouse died. What enteric viruses might have caused disease of this child? Coxsackie B ECHO virus *Coxsackie A Unclassified enteric viruses 68-71 Polioviruses *A 3-year-old child with severe diarrhea has been ill for 3 days. Viruses with two-layered capsid and pseudo-envelope resemble to wheel with spikes have been revealed into feces with electron microscopy. What type of viruses may it be? *Rotavirus Coxsackie virus ECHO virus Coronavirus Reovirus *2013* in our country, routine preventive vaccination against poliomyelitis involve using live vaccine that is administered orally. What immunoglobulins are responsible for development of local post-vaccination immunity in this case? Ig E Serum IgA Secretory IgA IgG IgM Rabies virus 187. A patient has been bitten by a dog. The dog was caught, and it was established that the animal is ill with rabies. What vaccine is to be used for specific prevention of rabies of this patient? A.*Live. B.Toxoid. C.Chemical. D. Recombinant. E.Synthetic. 152. A patient with an avulsed wound of shin caused by a rabid animal bite was delivered to a hospital. What vaccine is necessary to introduce for prevention of rabies development? A.ADT vaccine. B.APDT vaccine. C. *Antirabic vaccine. D.BCG. E. TABTe. 195. A hunter has referred for medical aid concerning the bites of hands by a wounded fox. What basic aid should be given to him for the specific prevention of rabies? A.Washing of the wound with soap solution. B.Surgical treatment of the wound. C.Introduction of antibiotics. D.*Introduction of rabies vaccine. E.Treatment of the wound with alcoholic iodine solution. *02*,*03* b-12 A person bitten with wild dog reffered to surgical department. There are wide avulsed wounds onto his face. Which therapeutic and prophylactic aid should be given to prevent rabies? Patient hospitalization and medical supervision Injection of DPT vaccine immediately Combined antibioticotherapy Injection of human normal immunoglobulin *to start immunization with antirabies vaccine Infectious mononucleosis virus 190. A student was hospitalized to an infectious department at the beginning of the disease. Infectious mononucleosis was suspected. Which result confirmed the diagnosis of this student on the day of hospitalization? A.Detecting antibodies to cytomegalovirus. B. Detecting IgM-antibodies to herpes simplex virus. C.Detecting 4-time quantity increase of antibodies to Epstein-Barr virus. D.Detecting of herpes simplex virus. E.*Detecting IgM antibodies to Epstein-Barr virus. Tick-born encephalitis *04*08* b-12 A patient with clinical signs of encephalitis was delivered to the infectious disease hospital. Anamnesis registers a tick bite. Hemagglutination-inhibition reaction helped to reveal antibodies to causative agent of tick-borne encephalitis in the dilution 1:20 which is not diagnostic. What actions should the doctor take after he had got such result? To examine the same serum To apply more sensitive reaction To deny diagnosis of tick-borne encephalitis *To repeat the examination with serum taken 10 days later To repeat examination with another diagnosticum *A doctor revealed symptoms of encephalitis in a child, 8-year-old. What is possible way of child infection besides of tick bite? *With milk taken from infected goats Via direct contact with ill person Alimentary way By inhalation via dust By inhalation via droplets A patient with fever, sleepiness turned with insomnia, and meningeal signs was hospitalized to clinic. From anamnesis it is known he drank unboiled goat milk 2 weeks ago. A primary diagnosis “tick-borne encephalitis” was made. Blood was taken for investigation and was injected into suckling mouse. After 5 days animals have hind limb paralysis, respiratory failure and death. What examination allows to make final diagnosis? Virus isolation onto chicken embryo *Neutralization test Color test Paired sera investigation with HA test Bioprobe is enough for diagnosis * A woman with clinical symptoms of encephalitis was consulted by infectious disease specialist. It is known from anamnesis she extracted tick from a leg a week ago. What methods should be used for isolation and identification of this virus? *Infection of suckling mice, neutralization test, CFT, IHA test with chicken erythrocytes Infection of guinea pigs, agglutination test with encephalitis diagnosticum, PHA test Infection of chicken embryo, CFT, precipitation test, RIA Infection of cell culture, CFT, neutralization test, HA test PCR, CFT, precipitation test with antiviral antibody Smallpox virus b-12 The contents of vesicles that appeared on the mucous membrane of a patient with variola was sent to a virological laboratory. Which of the listed changes were revealed during the smear microscopy? A Paschen bodies B Babes-Negri bodies C Guarnieri bodies D Babes-Ernst bodies E Syncytium Prions
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