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FORM-5
CONGRESS APPLICATION FORM

MEDİCAL BİOCHEMİSTRY CONGRESS
NAME SURNAME	E-MAIL ADDRESS		TITLE OF THE PAPER / ENGLISH	UNIVERSITY, FACULTY, DEPARTMENT, CITY, COUNTRY		MOBILE TELEPHONE NUMBERS	ORCID ID
Samandar Islomov	[e-mail]		Endocrinology and metabolism	Uzbekistan State University of Physical Education and Sports, Faculty of Medicine, Department of Sports Medicine and Biochemistry, Chirchik, Uzbekistan		[phone]
CORRESPONDING AUTHOR'S INFORMATION
NAME SURNAME		AUTHORS E-MAILS			MOBILE TELEPHONE NUMBERS
Samandar Islomov		[e-mail]			[phone]

* Submit your abstract in the same file as Form-5.

HORMONAL CHANGES IN INFERTILITY AND ITS TREATMENT. THE IMPORTANCE OF LUTEINIZING HORMONE
Samandar Islomov ^1
1 Uzbekistan State University of Physical Education and Sports, Faculty of Medicine, Department of Sports Medicine and Biochemistry, Chirchik, Uzbekistan.
^[e-mail], [phone]
Abstract
Endocrine infertility is a complex of hormonal disorders leading to irregular ovulation or its absence in women and impaired sperm quality in men. It is characterized by the absence of a desired pregnancy in combination with menstrual irregularities. Diagnosis of the causes involves a gynecological examination, hormonal examination, an RFE with an examination of endometrial scrapings. Treatment is aimed at correcting the identified hormonal abnormalities by therapeutic or surgical methods. In cases not amenable to treatment, IVF is indicated. The concept of "endocrine infertility" is a collective one, including various violations of the mechanisms of hormonal regulation of the menstrual cycle: at the hypothalamic-pituitary-ovarian level, in the TSH-thyroid gland, ACTH-adrenal cortex, etc. Regardless of the causes of endocrine infertility, its development is based ovarian dysfunction, manifested by persistent anovulation (absence of ovulation) or its irregularity. Normalization of impaired functions leads to pregnancy in 70-80% of cases of endocrine infertility. In other cases, the elimination of endocrine infertility by IVF is currently considered promising. In every third infertile woman, the cause of infertility lies in the pathology of the endocrine system. Luteinizing hormone (LH) is a gonadotropic peptide hormone of the anterior pituitary gland that stimulates the secretion of sex hormones (estrogen and progesterone) in men and women. In men, LH acts on the Leydig cells of the testes, activating the synthesis of testosterone in them, in women - on the cells of the ovary membrane and the corpus luteum, stimulates ovulation and activates the synthesis of estrogen and progesterone in the ovarian cells. In the middle of the menstrual cycle, there is a rise in LH levels, which is preceded (for 12 hours) by a preovulatory peak of estradiol. Ovulation occurs 12-20 hours after reaching the maximum concentration of LH.
Keywords: thyroid gland, Endocrine infertility, estrogen, progesterone