Pharmacology mcqs (final control) 3rd course

= Inhalation provides slow access to the general circulation

~ Subcutaneous administration may cause local irritation

8. 
   Most of drugs are distributed homogeneously.
   

~ True

= False

9. 
   Biological barriers include all except:
   

= Renal tubules

~ Cell membranes
~ Capillary walls
~ Placenta

10. 
    What is the reason of complicated penetration of some drugs through brain-blood barrier?
    

~ High lipid solubility of a drug
~ Meningitis

= Absence of pores in the brain capillary endothelium

~ vHigh endocytosis degree in a brain capillary

11. 
    Elimination rate constant (K_elim) is defined by the following parameter:
    

~ Rate of absorption
~ Maximal concentration of a substance in plasma
~ Highest single dose

= Half life (t ½)

12. 
    The most rapid eliminated drugs are those with high glomerular filtration rate and actively secreted but aren’t passively reabsorbed:
    

= True

~ False

13. 
    Systemic clearance (CL_s) is related with:
    

~ Only the concentration of substances in plasma
~ Only the elimination rate constant

= Volume of distribution, half life and elimination rate constant

~ Bioavailability and half life
14- Pharmacodynamics involves the study of following EXCEPT:
~ Biological and therapeutic effects of drugs