= All of the above
Correct statements about cortisol (hydrocortisone) include all of the following, EXCEPT:
~ Cortisol is synthesized from cholesterol
~ ACTH governs cortisol secretion
~ Most cortisol is inactivated in the liver
= The half-life of cortisol in the circulations is normally about 60-90 hours.
Correct statements about glucocorticoids include all of the following, EXCEPT:
~ Effects of glucocorticoids are mediated by widely distributed glucocorticoid receptors that are members of the superfamily of nuclear receptors.
~ Glucocorticoids have dose-related metabolic effects on carbohydrate, protein, and fat metabolism.
= Glucocorticoids have pro-inflammatory effects.
~ Glucocorticoids have catabolic effects in lymphoid and connective tissue, muscle, fat, and skin.
Physiologic doses of glucocorticoid can result in:
~ Increased liver glycogen stores, gluconeogenesis and lipolysis
~ Maintenance of cardiovascular function (by potentiation of norepinephrine) and skeletal muscle function
~ Increased hemoglobin synthesis, resulting in elevated of red blood cell count
= All of the above
prednisolonWhich of the following glucocorticoids is a short- to medium-acting drug?
= Prednisolon
~ Dexamethasone
~ Triamcinolone
~ All of the above
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