Pharmacology mcqs (final control) 3rd course

= ALFA_1a subtype mediates both vascular and prostate smooth muscle contraction

232- Indicate an alfa₁ adrenoreceptor antagonist, which has great selectivity for alfa_1a subtype:
~ Prazosin

= Tamsulosin

~ Phenoxybenzamine
~ Phentolamine
233- Subtype-selective alfa₁ receptor antagonists such as tamsulosin, terazosin, alfusosin are efficacious in:
~ Hyperthyroidism
~ Cardiac arrhythmias

= Benign prostatic hyperplasia (BPH)

~ Asthma

233- Indicate an alfa receptor antagonist, which is an efficacious drug in the treatment of mild to moderate systemic hypertension:

~ Phentolamine
~ Tolazoline
~ Ergotamine

= Prazosin

234- Which of the following alfa receptor antagonists is useful in reversing the intense local vasoconstriction caused by inadvertent infiltration of norepinephrine into subcutaneous tissue during intravenous administration?
~ Propranolol

= Phentolamine

~ Tamsulosin
~ Ergotamine
234- Beta-blocking drugs-induced chronically lower blood pressure may be associated with theirs effects on:
~ The heart
~ The blood vessels
~ The renin-angiotensin system

= All of the above

235- Characteristics of beta-blocking agents include all of the following EXCEPT:
~ They occupy beta receptors and competitively reduce receptor occupancy by catecholamines or other beta agonists
~ They do not cause hypotension in individuals with normal blood pressure

= They induce depression and depleted stores of catecholamines

~ They can cause blockade in the atrioventricular node
236- Beta-receptor antagonists have all of the following cardiovascular effects EXCEPT:
~ The negative inotropic and chronotropic effects