After preparation, the pituitary glands were fixed in 10% neutral formalin solution, weighed with
an accuracy of 1 mg, carried out according to the usual wiring, stained in all observations according to
McManus-Hotchkiss (PAS - reaction) with additional staining with orange “G” and Weigert’s hematoxylin,
hematoxylin and eosin. To assess the state o f the adenohypophysis, the proposed Chumachenko P.A. (1980)
the principle of deriving the agregate morphofunctional index (AMI) o f the pituitary gland for basophilic
cells of the adenohypophysis was used. It is calculated as follows: TMI o f basophilic cells o f the pituitary
gland = 0.1A + 0.25B + 0.5C, where A is the relative mass of the pituitary gland, mg / kg, B is the relative
mass o f the zone of predominance of basophilic adenocytes, mg / kg, C is the percentage o f basophils in the
zone of their predominance.
Results and discussion. In the control group of intact animals, the quantitative and qualitative mor
phofunctional parameters o f the adenohypophysis demonstrated their normal structure for the region. AMI
o f the activity of basophilic adenocytes varies from 1.02 to 2.50 points and averages 1.57±0.27 points.
In 7 days of the experiment, the AMI o f basophilic cells was 2.65±0.19 points, which exceeds the
indices of intact rabbits by 1.3 times.
On day 15, the complex indicator o f basophil activity - AMI varies from 2.60 to 3.90 points, and
averages 3.38±0.28 points.
By the 30th day of the experiment, the AMI for basophilic cells is 4.13±0.24 points, varying from
3.79 to 4.63 points.
The obtained results of changes in the complex of histophysiological parameters of the adenohy
pophysis under the influence of Ladyginozid, as follows from generally accepted views, indicate an in
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