caused a contraction of the aorta preparation, which was 95.3%±4.7% less than the contraction recorded
in the absence of the triazole. In these experiments, an increase in the concentration o f CaCl2 (0,5 mM- 2.5
mM) in the incubation medium was accompanied by a stepwise increase in the force o f contraction of the
aorta due to the penetration o f Ca2+ ions through the L-type Ca2+ channels.
Conclusions. The results o f these experiments convincingly indicate that the relaxant effect of the
test compound triazole-D-286 under conditions of KCl-induced contracture is associated with the suppres
sion of the transport o f Ca2 + ions from the extracellular medium to the SMC cytoplasm through voltage-de
pendent Ca2+ channels of the plasmalemma.
POTENTIAL FOR THE FORMATION OF L-ASPASE AGAINST
LYMPHOBLASTIC LEUKEMIA BY ENDOPHYTIC BACTERIA ISOLATED
FROM THE MEDICINAL PLANT AJUGA TURKESTANICA
Mamarasulov B.D., Umruzoqov A., Davranov Q.
Institute o f Microbiology o f the Academy o f Sciences o f Uzbekistan
bakhodir85@mail.ru +998941592882
L-ASPase is one o f the approved drugs for the treatment of soft tissue cancers such as lymphomas
and leukemias. In addition, it has been shown that this enzyme can effectively stop the growth o f some
tumors, especially liver carcinoma and colon cancer. The chloroform extract o f the plant Ajuga turkestani-
ca HeLa, HepG-2 and MCF-7 have a strong cytotoxic effect on cancer cells. Twelve endophytic bacterial
strains were isolated from the medicinal plant Ajuga turkestanica using standard microbiological meth
ods. Endophytic bacterial isolates were identified in MALDI-TOF MS. L-ASPase producing colonies were
identified by colony spotting method on the surface o f the M9 agar medium supplemented with 0.01 g/l
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