Таълим вазирлиги ўзбекистон республикаси соғЛИҚни сақлаш

Purpose of the study. evaluation of the cellular immunity in children with 
chronic glomerulonephritis.
Materials and methods. We observed 25 children aged 3 to 7 years old 
suffering from the nephrotic form of chronic glomerulonephritis (CGN). The 
control group consisted of 25 healthy children of the same age. Clinical diagnosis 
was based on history, clinical, laboratory and functional methods of research. 
We studied the cellular immunity and the concentration of circulating 
immune complexes (CIC). Indicators of cellular immunity was determined by the 
method of Garib F.Y. et al [7]. The phagocytic activity of neutrophils (PhAN) is 
determined by nitroblue tetrazolium test using latex particles [8], the circulate 
immune complex (CIC) precipitation method [9]. The material for the study of 
venous blood were taken in the morning on an empty stomach. Digital data is 
treated by variational statistics with the calculation of the reliability of the 
numerical differences. 
Results and its discussion. The results of the study revealed that the 
patients of the observed sex, girls accounted for 45,0%, 55,0% boys. According to 
the study of partial kidney function in patients with children revealed a decrease in 
the daily urine output, relative density of urine (P <0,001), increasing red blood 
cell and leukocyturia daily (P <0,01). There was a statistically significant increase 
in daily proteinuria, urea and serum creatinine (P <0,001). 
The results of immunological studies have shown that compared with the 
control group of children suffering from the nephrotic form of CGN in acute 
(before treatment) showed a statistically significant decrease in the percentage of T 
- lymphocytes (CD3), T - suppressor (CD8) T - helper cells (CD4 ), natural killer 
(LNK16), phagocyte active neutrophils (PhAN) (P <0.001), a significant increase 

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in the number of B-lymphocytes (CD19), (P <0,01) as well as the concentration of 
the CIC (P <0.001) (Table ). 
Identified immunopathological shifts due to the fact that in CGN types of 
immune response associated with one embodiment of lymphocyte activation 
involving preferential Th-lymphocyte clones first helper (Th1) or second (Th2) 
such as stimulating the development and immune response of cellular type. A 
chronic imbalance in the activation of T helper clones leads to the development of 
immunopathological reactions[4,5].