Bank of Krok testing to module N1


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Bog'liq
20150829-211235

A Cholera
B Typhoid fever
C Salmonellosis gastroenteritis
D Diphtheria
E Intestinal form of plague
83. In the feces of a patient with acute gastroenteritis there were revealed motile, slightly curved Gram-negative rods, which grow onto alkaline 1% peptone water in the form of tender bluish pellicle. What microorganisms have such properties?
A. Spirilla.
B.Spirochetes.
C.Clostridia.
D.Bacilli.
E.*Vibrios.

95. As a result of feces inoculation onto 1% alkaline peptone water after 8 hours' incubation with 37° C temperature a growth in the form of tender bluish pellicle was revealed. Microscopy revealed Gram-negative curved rods. What disease could these microorganisms cause?


A. Shigellosis.
B. Plague.
C. Typhoid fever.
D. Paratyphoid fever.
E. *Cholera.

100. A patient is hospitalized to an infectious department with cholera suspected. What basic method of research is necessary to use for the confirmation of the diagnosis?


A. Immunological.
B. *Bacteriological.
C. Biological.
D. Serologic.
E. Allergic.

118. Feces of a patient with cholera were delivered to a laboratory of extremely dangerous infections. What method of microbiological diagnostics is to be used to confirm or deny the diagnosis?


A. Virological.
B. Allergic.
C. Bacterioscopic.
D. Biological.
E. *Bacteriological.

127. From the vomit mass of a patient there were isolated very motile, slightly curved, Gram-negative rods which react positively with Inaba's diagnostic serum. What symptoms, most probably, will appear with the treatment absent?


A. Endotoxic shock.
B. Bacteremia.
C. *Fluid loss. (Dehydration)
D.Skin rash.
E. Ulcerous damages of intestine.

* A girl, 18 years old, from rural area of India has profuse diarrhea with fluid loss up to 8 liters a day. Which from given later microorganism may be reason of this infection?


*Vibrio cholera
Campylobacter jejuni
Enteropathogenic E.coli
Salmonella typhi
Shigella dysentheriae

“01”138. A patient with complaints of repeated diarrhea and vomiting, pain in muscles of legs, general weakness, and vertigo is hospitalized to an infectious department. After examination a doctor


has previously diagnosed cholera. Which method of investigation of the specimen from the patient should be used for express-diagnostics ?
A. *Immunofluorescence test.
B. Agglutination test
C. Bacteriological.
D. Allergic.
E. Biological.

*03* A patient with diarrhea was hospitalized into infectious disease department. Microscopy of feces revealed Gram-negative curved rods. Which disease may be suspected?


*Cholera
Salmonella gastroenteritis
Diphtheria
Enteric type of plague
Enteric fever

* A detection of serological variant of V.cholera allows to identify isolated strain and make a control of epidemic situation. Which way is it made by?


*Agglutination test with O-specific and type-specific sera
By Mukerje’s
By Heiberg’s
With detection of polymixin sensitivity
With agglutination of fowl erythrocytes

* Motile, slightly curved Gram-negative rods were isolated from patient’s vomiting mass and they were identified as cholera vibrio. Which test helps to differentiate classical variant of V.cholera from El-Tor biovar?


Agglutination with O-1 serum
Lactose fermentation
Growth onto 1% alkaline agar
*Growth onto agar with polymixin
“fish in steam” appearance at microscopy

Yersinia pestis


148. Microscopical examination of the sputum of a patient with acute pneumonia preliminary diagnosed has shown chaotically located microorganisms of ovoid form up to 2 microns long, more intensively stained on the poles. What the most probable diagnosis can be made on the basis of this data?


A. *Pneumonic plague.
B. Streptococcal pneumonia.
C. Staphylococcal pneumonia.
D. Klebsiella pneumonia.
E. Diphtheria.

*05* 171. In a mountain settlement mass death of rodents was observed. Simultaneously the inhabitants of this area were ill. The illness was accompanied by the fast rise of body temperature up to 40° C, apparent intoxication, increase of inguinal lymph nodes. In the touch smears of cadaveric material Gram-negative bipolarly stained ovoid rods were revealed. What microorganisms are the causative agents of this infectious disease?


Staphylococci.
Causative agents of anthrax.
*Causative agents of plague.
Causative agents of tularemia.
Clostridia.

* From dead rodent ovoid, Gram-negative, and bipolar stained bacteria have been isolated. What microorganism may it be?


*Causative agent of plague
Tubercle bacilli
Causative agent of syphilis
Staphylococcus
Streptococcus

* A geologist which has returned from expedition visited doctor and had typical for plague complaints. During examination doctor revealed symptoms of pneumonia. Which method of microscopy allows to reveal typical for causative agent of plague irregularity of staining?


With Pfeiffer’s fuchsine
*With methylene blue (by Loeffler)
With carbolic fuchsine (Ziehl’s fuchsine)
By Romanowsky-Giemsa
By Gram

*02* From the sputum of patient with headache, shivering, and cough Gram-negative, ovoid rods with bipolar staining have been isolated. They were located in chains into the smear from broth culture, and they formed R-forms of colonies onto agar. What disease is it typical for?


*Plague
Meningococcal nasopharingitis
Tuberculosis
Diphtheria
Streptococcal angina

Tularemia


*01* A man, 44 years old, muskrat hunter, has had heightening temperature up to 380С, headache, lid eyes edema, conjunctiva hyperemia, and surface ulcer onto the skin of neck. іIndicate the probable causative agent of disease:
Yersinia pseudotuberculosis
Brucella suis
Leptospira interrogans
Bacillus anthracis
*Francisella tularensis

*00* A doctor had suspected bubonic form of tularemia and sent clinical samples to laboratory for bacteriological method. Which feature of this method is at this definite case?


*Pure culture is isolated from infected laboratory animals
Pure culture is isolated on solid media
Pure culture is isolated on enriched media
Pure culture is isolated into liquid media
Isolated culture is identified due to antigenic structure

Brucella
114. During the swing of flu epidemic a milkmaid referred to a doctor with complaints of high body temperature, general weakness, absence of appetite, pain in joints. During 10 days she has been having self-treatment for flu. The infectiologist suspected brucellosis. Using what reaction is it possible to diagnose brucellosis?


A. *Wright's.
B.Wassermann test.
C.Coombs test.
D.Widal'stest.
E. Ouchterlony test.

*06* A veterinarian, working at cattle farm, visited doctor and complained of pain in joints, fever, weakness, night sweats. He has been ill for a month. According to complaints and patient profession doctor suspected brucellosis. Which material collected from this patient should be exameneed in ordinary bacteriological laboratory?


*blood serum
Cerebrospinal fluid
Vomiting mass
Urine
Feces

*00* From a patient, 40 years old, with acute feverish disease of unknown etiology blood was collected for serology at the 8th day of illness. After agglutination test with different diagnosticums it has been estimated that Widal test was positive at serum dilution 1:100, and Wright test - at serum dilution 1:400. Which diagnosis may be made according to serology results?


*Brucellosis
Enteric fever
Paratyphoid fever A
Paratyphoid fever B
Leptospirosis

84. During a scheduled examination milkmaids had a Burnet's intracutaneus allergy test. This test is used to detect hypersensitivity to:


A. *Brucellin.
B. Tuberculin.
C. Old tuberculin.
D. Tularin.
E. Antraxin.

126. A patient with an infectious disease has positive skin allergic Burnet's test. What diagnosis was confirmed by this test?


A. Q fever.
D. Salmonellosis.
B. Tularemia.
C. Typhoid fever.
E. *Brucellosis.

11. A patient with brucellosis has a positive Burnet's intracutaneous allergy test. Which immune system factor can induce inflammatory reaction in the site of brucellin introduction?


A. IgA.
B. *Sensitized T-lymphocytes.
C.IgE.
D.IgG.
E.IgD.

144. A child has brucellosis diagnosed. The child didn't have any contacts with sick animals. How could the infection get into the organism?


A. Via dirty hands.
B. Via dirty vegetables and fruit.
C. Via water.
D. *Via unpasteurized milk.
E. During injections.

Bacillus anthracis


119. During a biological test in touch smears from the organs of an animal streptobacteria surrounded with a capsule were revealed. It gives the basis to diagnose:


A. Tularemia.
B.*Anthrax.
C.Plague.
D. Brucellosis.
E.Croupous pneumonia.

* From horse carcass Gram-positive, capsulated, in size 8x1.5 µm, arranged in chains bacteria have been isolated. Which microorganism is it?


*Causative agent of anthrax
Causative agent of foot-and-mouth disease.
Streptococcus
Causative agent of hepatitis A.
Causative agent of tetanus.

*00* 98. A 34-year-old patient complained of carbuncle on his face. Examination revealed a painless thin edema of subcutaneous fatty tissue with a black eschar in the center, and vesicular eruption on the periphery. Microbiologic examination revealed nonmotile capsule-forming streptobacilli. What microorganisms are the causative agents of this disease?


A. *Bacillus anthracis.
B. Staphylococcus aureus.
C. Bacillus anthracoides.
Bacillus subtilis.
Bacillus megaterium.

* During microscopy of cattle-breeder’s eschar (scab) with suspicious anthrax typical Gram-positive rods surrounded with capsule have been revealed, that at cultivation onto nutrient media have formed colonies with “lion mane” appearance. Which drug should be used for prevention of anthrax in contact persons?


*Vaccine STI
Vaccine STI-1
Antitetanus serum
Sixanatoxin (Sixtoxoid)
Anti-anthrax gamma-globulin
*12* b-12 There was a record of some anthrax cases among animals in countryside. The spread of disease can be prevented by means of immunization. What kind of vaccine should be used?

  1. DPT vaccine

  2. Salk vaccine

  3. BCG vaccine

  4. Sabin`s vaccine

  5. STI live vaccine

*03*05*08* b-12 39.The territory of the old burial ground of cattle (for animal refuse), that has not been used for over 50 years, is planned for house building. But soil investigation has shown the presence of viable spores of an especially dangerous disease causative agent. Name the microorganism which could have been preserved in soil for such a long time.


A. Yersinia pestis.
B.Francisella tularensis.
C.Brucella abortus.
D. *Bacillus anthracis.
E.Mycobacterium bovis.

65. A man referred to the reception ward of an infectious disease hospital, having received by mail an envelope with suspicious powder. The man was isolated, and the powder was sent to the laboratory for detecting the presence of anthrax causative agent's spores. Which is the fastest method of detecting these microorganisms?


A. Isolation of pure culture.
B. Complement fixation test.
Precipitation in gel.
*Immunofluorescence test.
E. Neutralization test.

*00* 90. An extract of cattle-breading raw material was delivered to a laboratory from the area, where cases of anthrax among animals were noted. What serological reaction should be used for detecting anthrax causative agent antigens in the investigated specimen?


A. *Termoprecipitation.
B. Complement fixation test.
C. Indirect hemagglutination.
D. Radioimmunoassay.
E. Precipitation in agar.

106. In a laboratory for the examination of animal skins the precipitation test is used (Askoly test). The resultis: in some minutes after adding of the immune serum with skin extract an albescent ring formed. What does this result indicate?


A. *Presence of bacillus anthracis antigens.
B. Presence of Clostridium perfringens toxin.
C. Presence of brucellosis causative agent.
D. Presence of escherichia surface antigen.
E. Presence of salmonella Vi-antigen.

156. To check cattle-breeding raw material (leather, wool) for the presence of anthrax agent soluble thermostable antigen in water-salt extract from raw material is prepared. What reaction may be used for this purpose?


A. Neutralization.
B. Precipitation in agar.
C. Agglutination.
D. Indirect hemagglutination.
E. *Ring-precipitation.

Clostridium tetani


146. The causative agent of tetanus produces exotoxin with different biological action effects. What clinical symptoms can this toxin cause?


A. Disorders of vision.
B.* Lackjaw.
C. Diarrhea.
D. Skin rash.
E. Nausea.
*2013* A patient was consulted by a dentist due to limited mouth opening (trismus). He has a history of a stab wound of the lower extremity. What infection may cause these symptoms?

  1. Tularemia

  2. *Tetanus

  3. Whooping cough

  4. Brucellosis

  5. Wound anaerobic infection

* During earthwork one from the workers had been seriously injured. A surgery of his wound and penicillin injection had been made in a hospital. After 2 weeks he had spasms. Which drug could have been injected to patient besides given before?


Donor gamma-globulin
Interferone
*Antitoxin
Aminoglycosyde antibiotic
Tetracycline antibiotic

* After 48 hrs’ incubation into termostat of necrotic tissue homogenizate rough large flat colonies have grown onto the Zeissler blood agar. Colonies had tendency to “creeping” growth. Which properties of isolated microorganisms are noted in task description?


Morphological
*Cultural
Tinctorial
Proteolytic
Hemolytic

Clostridium botulinum


*06* 169. Jerked fish, being the cause of food poisoning, has been delivered to a bacteriological laboratory. The sample was cultured under anaerobic condition. After inoculation into Kitt-Tarozzi medium a bacteriologist has revealed microorganisms akin to a tennis-racket. What disease do they cause?


A. Typhoid fever.
B. Salmonellosis.
Dysentery.
Staphylococcal toxic infection.
E.*Botulism.

*05*06*07* b-12 163.A bacteriological laboratory conducts a research of canned meat for the presence of botulotoxin. An extract from the researched material with antitoxic antibotulinic serum of A, B, E types was injected to the experimental group of mice. An extract without antitoxic serum was injected to the control group.


What serologic test has been used?
A. Complement fixation.
B. Precipitation.
C. *Neutralization.
D.Opsonophagocytic.
E.Double immune diffusion.

59. A patient with the previous diagnosis of botulism has been hospitalized. What serological reaction should be used to determine botulinum toxin in test specimens?


A. Complement fixation test.
B. Agglutination.
C. *Neutralization.
D.Precipitation.
E.Immunofluorescence test.

94. After eating canned mushrooms a patient has bulbar paralysis symptoms: ptosis, diplopia, aphonia, and dysphagia. Botulism was previously diagnosed. What test should be used to determine the toxin type?


A. *Neutralization.
B. Agglutination.
Precipitation.
Complement fixation test.
E. Immunofluorescence test.

164.*2012* 2010* A student, having eaten meat, tinned in domestic conditions, has symptoms of food poisoning, caused by Clostridium botulinum: diplopia, dysphrasia, respiratory paralysis. What caused such symptoms of botulism?


A. Enterotoxin secretion.
B. C. botulinum invasion into intestinal epithelium.
C. *Neurotoxin action.
D.Endotoxic shock.
E.Activation of adenylate cyclase.

* A dried home-made fish was sent to laboratory as suspicious cause of severe food poisoning; symptoms of disease indicated action of severe exotoxin, that damaged nuclei of medulla oblongata. Which diagnosis was given in appointment card to laboratory assay?


Salmonellosis
Cholera
Dysentery
*Botulism
Enteric fever

*02*03*04* b-12 A patient N. admitted to hospital with complaints of vomiting, giddiness, diplopia, difficulty of swallowing. A doctor suspected botulism. Which methods of laboratory diagnostics should be used to confirm diagnosis?


A. *Biological probe, bacteriological
B. Allergic test, serology
C. bacteriological, mycological
D. protozoological, microscopy
E. –

* A patient with suspicious food poisoning has been made a diagnosis “botulism”. Which tactics of doctor will be? Which drugs should be administered for treatment of patient?


*Gastric lavage, antibotulism sera, antibiotics
Antibiotics, vaccine
Gastric lavage, vaccine, antibiotics
Antibotulism sera, vaccine
Gastric lavage, vaccine, antibiotics

Gas gangrene infection


*From wound discharge of patient with suspected gas anaerobic infection next bacterium was isolated: Gram-positive rod, 6x1.5 µm in size, with subterminal spore, and it can form capsule into the host organism. What microbe is it?
*Clostridium perfringens
Clostridium tetani
Clostridium botulinum
Clostridium hystoliticum
Bacillus anthracis

* A patient with suspicious gas gangrene infection was admitted to hospital. Which medium should patient sample be inoculated?


*Kitt-Tarozzi
Levin’s
Endo
Muller’s
Rassel’s

* Filtrates prepared from broth cultures of gas gangrene causative agents have poured into test tubes, then added species antitoxic sera and have being remained at room temperature for 40 minutes. For detection of anaerobic species it is necessary now:


*Inoculate the test tube contents into animal
Add agglutinating diagnostic serum into test tubes
Inoculate content of test tubes onto solid nutrient media
Add precipitating diagnostic serum into test tubes
Add erythrocytic diagnosticum into test tubes

21. A patient injured in an accident has been suspected of probable development of anaerobic wound infection (gas gangrene). What is the most appropriate treatment before making a specific laboratory diagnosis?


A. Native plasma.
B.Toxoid.
C. Type specific immune serum.
D. *Polyvalent specific serum.
E.Placental γ-globulin.

*07* A sample from patient’s wound has admitted to laboratory. Which microbiological method may indicate species belonging of causative agent?


*Bacteriological
RIA
Serological
Allergic
Bacterioscopy

b-12 A laboratory received a material from a patient's wound. Preliminary diagnosis is gaseous gangrene. What microbiological method should be applied to determine species of causative agent?



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