Kniga na apstrakti book of abstrcts
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^ETVRTI KONGRES NA FARMACIJATA NA MAKEDONIJA SO ME\UNARODNO U^ESTVO Ohrid, R. Makedonija, 26-30 septemvri, 2007 godina FOURTH CONGRESS ON PHARMACY OF MACEDONIA WITH INTERNATIONAL PARTICIPATION Ohrid, R. Macedonia, September 26-30, 2007 KNIGA NA APSTRAKTI BOOK OF ABSTRCTS ii NAU^EN ODBOR Pretsedatel President SCIENTIFIC COMMITEE Svetlana Kulevanova Svetlana Kulevanova Sekretar Secretary Aleksandra Grozdanova Aleksandra Grozdanova ^lenovi Members Qubica [uturkova Ljubica Suturkova Suzana Trajkovi}-Jolevska Suzana Trajkovic-Jolevska Aneta Dimitrovska Aneta Dimitrovska Lidija Petru{evska-Tozi Lidija Petrusevska-Tozi Katerina Gora~inova Katerina Goracinova Aleksandar Dimovski Aleksandar Dimovski Biljana Bauer-Petrovska Biljana Bauer-Petrovska Kristina Mladenovska Kristina Mladenovska Tatjana Kadifkova-Panovska Tatjana Kadifkova-Panovska Renata Slaveska-Rai~ki Renata Slaveska-Raicki Zoran Kavrakovski Zoran Kavrakovski ORGANIZACIONEN ODBOR Pretsedatel President ORGANISING COMMITEE Suzana Trajkovi}-Jolevska Suzana Trajkovic-Jolevska Liljana Ugrinova Liljana Ugrinova Marija Glava{-Dodov Marija Glavas-Dodov Vesna Ognenoska Vesna Ognenoska Slavica Maleska-Stojadinovi} Slavica Maleska-Stojadinovic Gordana [irkova Gordana Sirkova Sowa Tasevska Sonja Tasevska Ana Dimitrova Ana Dimitrova Olgica Martinovska Olgica Martinovska iii PREDGOVOR Ovoj broj na Makedonski farmacevtski bilten e specijalen broj na spisanieto posveten na ^etvrtiot kongres na farmacijata na Makedonija so me|unarodno u~estvo. Vo spisanieto se opfateni apstraktite koi od Nau~niot odbor se prifateni za prezentacija na Kongresot. Apstraktite se pe~ateni vo originalnata forma vo koja se dostaveni od avtorite, bez lektorirawe i dopolnitelno tehni~ko oblikuvawe ili pre~ukuvawe pa poradi toa ovoj broj tehni~ki go nema voobi~aeniot standard na Makedonskiot farmacevtski bilten. Avtorite se potpolno odgovorni za sodr`inite na nivnite soop{tenija. PREFACE The present of Macedonian pharmaceutical bulletin is special issue of the Fourth Congress on Pharmacy of Macedonia with International Participation. This issue of Macedonian pharmaceutical bulletin contains abstracts accepted by the Scientific Commitee for the presentation at the Congress. Abstarcts were printed in the original from exactly as submited by the autors, without lecture, technical editing or retyping. The layout quality does therefore not meet the Journal’s usual standard. The autors are fully responsible for the contents of their communications. iv S O D R @ I N A / CONTENT v ^ETVRTI KONGRES NA FARMACIJATA NA MAKEDONIJA SO ME\UNARODNO U^ESTVO FOURTH CONGRESS OF PHARMACY OF MACEDONIA WITH INTERNATIONAL PARTICIPATION PLENARNI KONGRESNI PREDAVAWA CONGRESS PLENARY LECTURES CPL - 1 Atilla Hincal, Erem Bilensoy Targeted Nanoparticles for Cancer Therapy…………………………………………………...2 CPL - 2 Peter Castle European Quality Standards for Medicines: the European Pharmacopoeia and the European Directorate for the Quality of Medicines & HealthCare (EDQM) ……………….……..……...3 CPL - 3 F. David, P. Sandra Recent trends in pharmaceutical analysis………………………………………………….…...4 CPL - 4 Danijel Kikelj, Janez Ilas Toward a novel class of antithrombotic compounds with dual function………………………...5 AKADEMSKA SEKCIJA ACADEMIC SECTION SL - 1 Bjarne Fjalland Continuous education in Pharmaceutical Sciences – the art of survival…………….…………..8 SL - 2 Peep Veski Pharmacy Education in New EU Countries………………………………………………...9-10 SL - 3 Roberto Della Loggia Teaching Pharmacy in Italy…………………………………………………………………...11 SP - 1 Aleksandra Grozdanova, Carmen Fernandez Pneumococcal conjugate vaccines: synthesis and immunogenic profile…………………...12-13 Aleksandra Grozdanova, Karmen Fernandez, Pneumokokni konjugatni vakcini: sinteza i imunogen profil SP - 2 Kapedanovska Aleksandra, Toni Josifovski Ljubica Suturkova, Birgitta Norling, Aleksandar J. Dimovski Proteomic analysis of colorectal cancer by two-dimensional gel electrophoresis…...……..14-15 Kapedanovska Aleksandra, Matevska Nadica, Sterjev Zoran, Serafimovska Zorica, Hiqadnikova Bajro Marija, [uturkova Qubica, Birgita Norling, Dimovski Aleksandar Proteomska analiza na kolorektalen karcinom so upotreba na dvodimenzionalna gel elektroforeza SP - 3 Ana Poceva Panovska, Goran Widmalm Structural analysis of Escherichia coli O181 O-polysaccharide antigen…………………...16-17 Ana Poceva Panovska, Joran Vidmalm Strukturna analiza na O-polisahariden antigen od Escherichia coli O181 SP - 4 Ana Poceva Panovska, Goran Widmalm Synthesis of monosaccharide units towards the synthesis of fucosylated N-linked hexasaccharide of a glycoprotein from Haemonchus contortus………….……………......18-19 Ana Poceva Panovska, Joran Vidmalm Sinteza na monosaharidni edinici za sinteza na fukoziliran N-povrzan heksasaharid prisuten kaj glikoprotein na Haemonchus contortus PLENARNI KONGRESNI PREDAVAWA CONGRESS PLENARY LECTURES AKADEMSKA SEKCIJA ACADEMIC SECTION vi ^ETVRTI KONGRES NA FARMACIJATA NA MAKEDONIJA SO ME\UNARODNO U^ESTVO FOURTH CONGRESS OF PHARMACY OF MACEDONIA WITH INTERNATIONAL PARTICIPATION SP - 5 Gjoshe Stefkov, Anna Jager, Per Molgaard, Knud Josefsen, Svetlana Kulevanova Antiinflammatory and antidiabetic activity of Teucrium polium extracts ..……………......20 -21 \o{e Stefkov, Knul Jozefsen, Ana Jager, Pjer Molgard, Svetlana Kulevanova Ispituvawe na antiinflamatorna i antidijabeti~na aktivnost na ekstrakti od Teucrium polium (Lamiaceae) SP - 6 Jasmina Tonic -Ribarska, Suzana Trajkovic -Jolevska, Kim Grimstrup Madsen , Bente Gammelgaard Separation of metabolites of Ebselen in human and rat urine by LC-ICP-MS after solid phase extraction …………….……………………………..... .... ..22 SP - 7 Katerina Brezovska Production of monoclonal antibodies against glycoprotein isolated from human peripheral nerve …………………………………………..…..….. ..... .23 SP - 8 Maja Simonoska Crca revska, Katerina Goracinova, Marija Glavas Dodov, Bente Steffansen Uptake studies of chitosan - Ca-alginate microparticles loaded with 5 -FU in human intestinal cell lines …………….…………………………… ….. ..24 SP - 9 R. Petkovska, A. Dimitrovska, C. Cornett Chemometric approach for developement, optimization and validation of RP RR -HPLC metods for simultaneous determination of therapeutically active substances and their related compounds ……………..….……...2 5-26 R. Petkovska, A. Dimitrovska, K. Kornet Hemometriski prista p pri eksperimentalno dizajnirawe na RP RR HPLC metodi za ednovremeno opredeluvawe na terapevtski aktivni supstancii nivni srodni soedinenija SP – 10 Zoran Sterjev, Henrik T. Vestergaard, Suzanne L. Hansen Does Cerebral Cortical Brain Slices from PTZ - kindled mice provide a more predictive screening model for antiepileptic drugs?..……………………... 27-28 Zoran Sterjev, Henrik T. Vestergard Suzane L. Hansen Dali cerebralno kortikalnite mozo~ni preseci dobieni od eksperimentalni gluvci prethodno tretirani so pentatetrazol mo`at da ovozmo`at podobar predviduva~ki model za antiepilepti~nite lekovi? SP - 11 Zorica Serafimoska, Ewa Szymanska, Darryl Pickering, Karla Frydenvang, Jette Kastrup and Tommy N. Johansen Structural based drug research on ionotropic Glu tamate receptors .………………..……. 29-30 Zorica Serafimoska, E va Szimanska, Daril Pikering, Karla Fridenvang, Jete Kastrup , Tomi N. Johansen Ispituvawe na jonotropnite glutaminski receptori bazirana na nivnata struktura FARMACEVTSKA TEHNOLOGIJA I BIOFARMACIJA PHARMACEUTICAL TECHNOLOGY AND BIOPHARMACY SPL - 1 Henning Gjelstrup Kristensen Formulation of poorly soluble drugs for oral administration....………………………………...3 2 SPL - 2 Peep Veski Chronopharmaceutical drug delivery...……………………………………………… ........3 3-34 SPL - 3 D. Duchêne, S.C. Yu, L. Trichard, M. Seiller, A. Bochot Cyclodextrins in lipid dispersed systems...………………………………………………..… ....3 5 SPL - 4 Mirjana Gasperlin Microemulsions containing antioxidants as skin protective agents.....…………………………... 36 FARMACEVTSKA TEHNOLOGIJA I BIOFARMACIJA PHARMACEUTICAL TECHNOLOGY AND BIOPHARMACY vii ^ETVRTI KONGRES NA FARMACIJATA NA MAKEDONIJA SO ME\UNARODNO U^ESTVO FOURTH CONGRESS OF PHARMACY OF MACEDONIA WITH INTERNATIONAL PARTICIPATION SOP - 1 Sema Calis Implantable Biodegradable Microparticles for Orthopoedical Applications ………….………. 37 SOP - 2 Katerina Goracinova Spray-dried chitosan -Ca-alginate microparticles as GIT drug delivery systems .…………..….38 SOP - 3 Emilija Janevik -Ivanovska Pharmaceutical aspects of positron emission tomography (PET) implemetation .…………. 39-40 Emilija Janevi} -Ivanovska Implementacija na pozitronska emisiona tomografija - farmacevtski aspekt PP - 1 Meri Davceva, Katerina Goracinova Formulation of Immediate Release Metronidazole Tablets .………………………….…….41-42 Meri Dav~eva, Katerina Gora~inova Formulacija na metronidazol tableti so brzo osloboduvawe PP - 2 K. Mladenovska, O. Cruaud, R. S. Raicki, M. G. Dodov, M. S. Crcarevska, E. I. Janevik, Z. Kavrakovski, K . Goracinova Dissolution profile of 5 -ASA loaded in chitosan -Ca-alginate microparticles; influence of formulation variables .………………………………………………………..4 3-44 K. Mladenovska, O. Krio, R. S. Rai~ki, M. G. Dodov, M. S. Crcarevska, E. I. Janevi}, Z. Kavrakovsk i, K. Gora~inova Osloboduvawe na 5 -Aminosalicilna kiselina od citozan -kalcium-alginatni mikro~esti~ki; vlijanie na formulaciskite promenlivi PP - 3 M. Glavas Dodov, A. A. Hincal, S. Calis, M. Simonoska Crcarevska, N. Geskovski and K. Goracinova Spray-dried chitosan -Ca-alginate microparticles for colon delivery of 5 -FU.……….……. 45-46 M. Glava{ Dodov, A. A. Hin~al, S. ^alis, M. Simonoska Crcarevska, N. Ge{kovski i K. Gora~inova Sprej-su{eni citozan -kalcium-alginatni mikro~esti~ki so 5 -FU za naso~eno d eluvawe vo kolon PP - 4 B. Nestorovska -Gjosevska, M.Glavas -Dodov, K. Goracinova Orally disintegrating tablet: Formulation design and Optimisation using Response surface methodology .…………………………………………………….. 47-48 B. Nestorovska -\o{evska, M. Glava{ -Dodov, K. Gora~inova Peroralna disperzibilna tableta: Formulaciski dizajn i Optimizacija so primena na Response surface Metodologija PP - 5 Nada Popstefanova, Sonja Sterjevska, Miroslava Ilievska Developing applicable integfrated pharmaceutical quality system with risk-based approach .…………………………………………………………… ….. …... 49 PP - 6 B. Arica, S. Calis, K. Goracinova, A.A. Hincal In vitro evaluation of 5 -Fluorouracil -loaded enteric coated PLGA microparticles prepared by spray-drying technique .……………………………….…………..50 PP - 7 Natasa Anevska -Stojanovska, Katerina Goracinova Scale-up of fluid -bed granulation of paracetamol …………………………………………..51-52 Nata{a Anevska -Stojanovska, Katerina Gora~inova Zgolemuvawe na procesot na vrtlo`na granulacija na paracetamol PP - 8 Meri Davceva, M. Simonoska Crcarevska, N. Geskovski, Katerina Goracinova Optimization of Metronidazole Tablet formulation using Response Surface Experimental Design ……………………………………………..5 3-54 Meri Dav~eva, M. Simonoska Crcarevska, N. Ge{kovski, Katerina Gora~ino va Formulacija na Metronidazol tableti so brzo osloboduvawe viii ^ETVRTI KONGRES NA FARMACIJATA NA MAKEDONIJA SO ME\UNARODNO U^ESTVO FOURTH CONGRESS OF PHARMACY OF MACEDONIA WITH INTERNATIONAL PARTICIPATION PP - 9 M. Simonoska Crcarevska, M. Glavas Dodov, K. Goracinova Enteric coated chitosan- Ca-alginate microparticles for colon drug delivery ……………….55 -56 M. Simonoska Crcarevska, M. Glava{ Dodov, K. Gora~inova Enterosolventni citozan -Ca-alginatni mikro~est i~ki za naso~eno i kontrolirano osloboduvawe na lekovita supstancija vo kolon PP - 10 Suncica Jordanoska, Marija Glavas Dodov, Katerina Goracinova Experimental design of cetirizine dihidrochloride chewable tablets formulation ………….57 -58 Sun~ica Jordano ska, Marija Glava{ Dodov, Katerina Gora~inova Eksperimentalen dizajn na formulacija na tableti za xvakawe so cetirizin dihidrohlorid PP - 11 Elena Tomovska, M. Simonoska Crcarevska, N. Geskovski, Katerina Goracinova Filtration in sterile production ………… ………………………………………………….59 -60 E. Tomovska, M. Simonoska Crcarevska, N. Ge{kovski, K. Gora~inova Filtracija vo sterilno proizvodstvo PP - 12 Hristina Litovin, Stojne Tanevska, Gorica Pavlovska The influence of the diluents on the release rate of diclofenac sodium from hydrophylic matrix system ……………………………………………………….…..61 -62 Hristina Litovin, Stojne Tanevska, Gorica Pavlovska Vlijanie na polnitelite na brzinata na osloboduvawe na diklofenak natrium od hidrofilen matriks sistem PP - 13 M. Pasic, Gabriele Betz, Seherzada Hadzidedic, Silvia Kocova El -Arini, Hans Leuenberger Accelerated stability testing and shelf -life prediction …………………………………………..63 PP - 14 E. Hadzovic, G. Betz, S. Hadzidedic, S. Kocova El -Arini, H. Leuenberger Effect of roll compaction on disintegration time and dissolution rate of Theophilline ………...64 PP - 15 Gabriele Betz New concepts in process technology and Pharmaceutical Drug formulation Design …………..65 PP - 16 Gabriele Betz Non-invasive drug delivery ………………………………………………………… ………….66 PP - 17 E. Adamova, R. Dameska, M. Anevska, D.Lepcevska, E. Spaseska -Aleksovska Orally Disintegrating Tablets (ODT) - Trends and Recent Developments ……………...….67 -68 E. Adamova, R. Dameska, M. Anevska, D. Lep~evska, E. Spaseska -Aleksovska Oralno Dezinteg rira~ki Tableti ( ODT) - trendovi i najnovi soznanija PP - 18 V. Dinik, L. Makraduli, D. Dimova, E. Spaseska - Aleksovska Inffluence of Methylcellulose and Hypromellose on the physical properties of the Metformin HCl tablet cores 850 mg ……………………….………..…. 69-70 V. Dini}, L. Makraduli, D. Dimova, E. Spaseska - Aleksovska Vlijanie na Methylcellulose i Hypromellose na fizi~kite karakteristiki na Metformin hidrohlorid tabletni jadra 850 mg PP - 19 S. Fako, E. Satrovic, S. Bojo - Omeragic, M. Dzambic, L. Zil ic Marjanovic, S. Hadzidedic Effect of packaging and storage on the stability of Amlodipine besylate tablets ……………….71 PP - 20 I. Homsek, J. Parojcic, N. Cvetkovic, Z. Guric Application of experimental design for screening study of dissolution testcond itions: carbamazepine immediate -release tablets …………………….…….72 PP - 21 Arsic I., Homsek I., Gorgevic S., Tadic V. The influence of O/W cream structure on ITS hydration potential: in vivo case study ..… … . . … . 73 PP - 22 Slavica Maleska Stojadinovic Making a jell y with Bensoyl peroxide and Erythromycin …………………………….……74 -75 Slavica Maleska -Stojadinovi} Izrabotka na gel so Benzoyl peroxyd i Erytromycin ix ^ETVRTI KONGRES NA FARMACIJATA NA MAKEDONIJA SO ME\UNARODNO U^ESTVO FOURTH CONGRESS OF PHARMACY OF MACEDONIA WITH INTERNATIONAL PARTICIPATION PP - 23 S. Kostic, D. Jagodic, S Hadzidedic Defining critical steps during formulation development of semisolids using rheology measurement ……………………...…………………………..… …………………..………. .76 PP - 24 Dimitar Rachev, Bistra Kostova New copolymer zwitterionic matric es for drugs release with basic properties …………………………………………………………………………... 77 PP - 25 A. Nalo, S. Miljus, E. Vranjes, S. Hadzidedic Discriminatory dissolution profile for Diclofenac sodium retard tablets 100 mg …………….… 78 PP - 26 S. Kostic, M. Mihajljica, N. Saric, S. Hadzidedic Comparative rheological measurements on corticosteroid ointments from the manufacturers available on the market …….………………………………..………. 79 PP - 27 Z. Babic, H. Trobradovic, S. Hadzidedic Preformulation studies as a starting points i n selection of polymorphic form in generic drug development ………………………………………….…. 80 PP - 28 L. Zilic Marjanovic, S. Hadzidedic, H. Trobradovic, V. Mekinjic Forced degradation studies for better understanding of active pharmaceutical ingredient …….………………………… ……………………..……. 81 PP - 29 S Hadzidedic, L. Zilic,V. Mekinjic, S. Kocova El -Arini Defining primary criteria for the choice of an optimal salt for designing of amlodipine tablets formulation ……………………………………………………………………….…………....8 2 PP - 30 Haris Trobradovic, Seherzada Hadzidedic, Lejla Zilic,Vlado Mekinjic, Hans Leuenberger, Silvia Kocova El -Arini, Gabriele Betz Use of thermal analysis and stress test to identify stability problems in multicomponent generic products due to process change and reformulation … … …..….. … .83 PP - 31 Aleksandra Petrovic, Svetlana Ibric, Svetlana Trajkovic, Radmila Popovic, Dragica Popadic, Zorica Guric Factorial design evaluation of formulation of factors on the drug release from HPMC matrices ……………………………………………………………….…. 84 PP - 32 Marta Pocuca, Dragan Stupar Pharmaceutical forms Anantidotarioum Nicolai …………………… ………..… … …… ….… .85 PP - 33 E. Najdovska, Z. Veljanova Adrenaline injection, formulation and pharmacodinamic efficasy …………………………. 86-87 E. Najdovska, Z. Veljanova Adrenalin a mpula – formulacija i farmakodinamski efekt PP - 34 Sonja Maleva, Sonja Ugarkovic, Efta Linin Retrospective validation of manufacturing process for Analgin tablets 500 mg …. ….…. …. 88-89 Sowa Maleva, Sowa Ugarkovi}, Efta Linin Retrospektivna validacija n a proizvodniot proces na Analgin tableti 500 mg PP - 35 Snezana Angeleska, D. Trombeva, T. Ilioska -Nabrezanec Comparative methods for production of Natrii Hydrogencarbonatis Infundibile …………..9 0-93 S. Angeleska, D. Trombeva, T. Ilieska -Nebre`anec Komparativni metodi na izrabotka na Natrii Hydrogencarbonatis Infundibile x ^ETVRTI KONGRES NA FARMACIJATA NA MAKEDONIJA SO ME\UNARODNO U^ESTVO FOURTH CONGRESS OF PHARMACY OF MACEDONIA WITH INTERNATIONAL PARTICIPATION PP - 36 S. Memed Sejfulah, Lj. Krsteska, S.Ugarkovic, K. Brzilova Selection of stable formulation of Risperidone solution in preformulation stage ……………………………………………………………… .…. ..94-95 S. Memed Sejfulah, Q. Krsteska, Sowa Ugarkovi}, K. Brzilova Izbor na stabilna formulacija na Risperidon rastvor vo predformulaciona razvojna faza PP - 37 M. Dastevska Mitevska, M. Glavas Dodov, K. Goracinova Formulation and evaluation of diazepam hydroge for rectal administration …….…… …..96 -97 M. Da{tevska Mitevska, M. G lava{ Dodov, Katerina Gora~inova Formulacija i ispituvawe na diazepam rektalen gel KLINI^KA FARMACIJA I BIOMOLEKULARNI NAUKI CLINICAL PHARMACY AND BIOMOLECULAR SCIENCES SPL - 5 Carmen Fernandez Strategies for vaccine improvement. The use of mi crobial Heat Shock Proteins as adjuvants or carrier molecules..………….…….10 0 SPL - 6 J. Gogusev Therapeutic significance of recurrent gene fusions in hematological and epithelial tumors ………………………………………………..……...10 1 SPL - 7 Tommy N. Johansen, Ewa Szymanska, D arryl Pickering, Zorica Serafimoska, Elena Frola Structure-based design of s AMPA receptor antagonists ……………………………………………………………….....10 2 ubtype -selective SPL - 8 Unsal Calis Studies on Synthesis and Evaluation of Anticonvulsant Drugs …………………………….....10 3 PP - 38 S. Kuzmanovska, O. Vaskova, T. Tripunoski, M. Kocovska - Zdraveska, C. Decristoforo Download 4.82 Kb. Do'stlaringiz bilan baham: 
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