= mThromboembolism
~ Metabolic acidosis
127- All of the following are undesirable effects of aspirin EXCEPT:
~ Gastritis with focal erosions
= Tolerance and physical addiction
~ Bleeding due to a decrease of platelet aggregation
~ Reversible renal insufficiency
128- Characteristic findinds of salicylism include:
~ Headache, mental confusion and drowsiness
~Tinnitus and difficulty in hearing
~ Hyperthermia, sweating, thirst, hyperventilation, vomiting and diarrhea
= All of the above
129- Analgin usefulness is limited by:
= Agranulocytosis
~ Erosions and gastric bleeding
~ Methemoglobinemia
~ Hearing impairment
130- This drug group useful in angina increase myocardial oxygen delivery (by reversing coronary arterial spasm) and does not decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand):
~ Beta-adrenoceptor-blocking drugs (Atenolol, Metoprolol):
= Myotropic coronary dilators (Dipyridamole)
~ Calcium channel blockers (Nifedipine, Nimodipine)
~ Potassium channel openers (Minoxidil)
131- Which of the following statements concerning nitrate mechanism of action is True?
~ Therapeutically active agents in this group are capable of releasing nitric oxide (NO) in to vascular smooth muscle target tissues
~ Nitric oxide (NO) is an effective activator of soluble guanylyl cyclase and probably acts mainly through this mechanism
~ Nitrates useful in angina decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and increase myocardial oxygen delivery (by reversing coronary arterial spasm)
= All of the above
132- Which of the following nitrates and nitrite drugs are long-acting?
~ Nitroglycerin, sublingual
~ Isosorbide dinitrate, sublingual (Isordil, Sorbitrate)
~ Amyl nitrite, inhalant (Aspirols, Vaporole)
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