Pharmacology mcqs (final control) 3rd course

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~ Substances produced by some microorganisms and their synthetic analogues that inhibit the growth of organism cells
~ Synthetic analogues of natural substances that kill protozoa and helminthes
190- General principles of anti-infective therapy are:
~ Clinical judgment of microbiological factors
~ Definitive identification of a bacterial infection and the microorganism’s susceptibility
~ Optimal route of administration, dose, dosing frequency and duration of treatment

= All of the above

191- Mechanism of penicillins’ antibacterial effect is:

= Inhibition of transpeptidation in the bacterial cell wall

~ Inhibition of beta-lactamase in the bacterial cell
~ Activation of endogenous proteases, that destroy bacterial cell wall
~ Activation of endogenous phospholipases, which leads to alteration of cell membrane permeability
192- Pick out the beta-lactamase inhibitor for co-administration with penicillins:
~ Clavulanic acid
~ Sulbactam
~ Tazobactam

= All of the above

193- Cephalosporines are drugs of choice for treatment of:
~ Gram-positive microorganism infections
~ Gram-negative microorganism infections

= Gram-negative and gram-positive microorganism infections, if penicillins have no effect

~ Only bacteroide infections
194- Carbapenems are effective against:
~ Gram-positive microorganisms
~ Gram-negative microorganisms
~ Only bacteroide infections

= Broad-spectum

195- All of the following antibiotics are macrolides, EXCEPT:
~ Erythromycin
~ Clarithromycin