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Antidiabetic drugs

Antidiabetic Agents Oral Agents

  • Thiazolidinediones: Troglitazone (Rezulin) - unrelated to other antidiabetic drugs
  • - Action - Decrease insulin resistance, helps muscle cells respond to insulin & use glucose more effectively
  • - May be used w/ sulfonylurea, metformin, or insulin
  • - May cause serious hepatic toxicity - Not used in England
  • Rapaglinide (Prandin) - classification unknown - Newest
  • - For use alone or w/ metfromin - short acting
  • - Action - similar to sulfonylureas, but does not cause hypoglycemia

Antidiabetic Agents Oral Agents

  • Hyperglycemic Drugs - Glucagon
  • - Action - A hyperglycemic hormone secreted by the alpha cells of the islets of Langerhans - Inc. bld sugar by stimulating glycogenolysis (breakdown of glycogen to glucose) in the liver - protects body cells
  • - Use - Insulin-induced hypoglycemia when other methods not available or not working
  • - Clients prone to hypoglycemia should keep in home & family members taught how to use
  • - Begins to work in 5 to 20 min.

Antidiabetic Agents Oral Agents

  • Diazoxide (Proglycem) - chemically related to thiazide diuretics
  • - Action - Inc. bld sugar by inhibiting insulin release from the beta cells & stimulating release of epi (adrenalin from the adrenal medulla
  • - Use - Chronic hypoglycemia caused by hyperinsulinism d/t islet cell Ca or hyperplasia
  • - Not used to Rx hypoglycemic rxns
  • - Parenteral form (Hyperstat) used for malignant HTN
  • - Oral diazoxide usually does not cause hypotension

E’tiboringiz uchun Rahmat!


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