Biokimyo pmd

MUNDARIJA
KIRISH ............................................................................................................. 3
I BOB
OQSILLAR VA ULARNING FUNKSIYASI
Oqsillarning elementar tarkibi .......................................................................... 8
Oqsillarning aminokislota tarkibi va aminokislotalarning tasnifi .................... 8
Oqsillarning fizik-kimyoviy xususiyatlari ..................................................... 12
Oqsillarning molekulyar massasi ................................................................... 12
Oqsil molekulalarining shakli va o‘lchami .................................................... 16
Oqsillarning fizik va kimyoviy xossalari ....................................................... 16
Oqsillarning tuzilishi ...................................................................................... 19
Oqsillarning birlamchi strukturasi .................................................................. 20
Oqsillarning ikkilamchi strukturasi ................................................................ 23
Oqsillarning uchlamchi strukturasi ................................................................ 26
Oqsillarning to‘rtlamchi strukturasi ............................................................... 27
Oqsillarning to‘rtlamchi strukturasining hosil bo‘lishi .................................. 28
Oqsillarning denaturatsiyasi. Qaytar va qaytmas denaturatsiya ..................... 29
Oqsillarni ajratib olish va tozalash ................................................................. 30
Oqsillarni fraksiyalash yo‘li bilan ajratish ..................................................... 31
Oqsillarni tuzlar ta‘sirida cho‘ktirib ajratish .................................................. 31
Dializ usuli ..................................................................................................... 32
Elektroforez usuli ........................................................................................... 33
Oqsil strukturasini o‘rganish usullari ............................................................. 34
Oqsillarning tasnifi va nomenklaturasi .......................................................... 34
Oqsillarning biologik xossasini birlamchi strukturaga bog‘liqligi ................ 36
Oqsillarning birlamchi strukturasining turga oid spetsifikligi ...................... 37
Oqsillarning biologik xossasining konformatsiyasiga
(ikkilamchi va uchlamchi strukturaga) bog‘liqligi ....................................... 38
Oqsil molekulasining funksiya bajarishiga bog‘liq
bo‘lgan konformatsion o‘zgarish ................................................................... 39
Oqsillarning strukturasi va ko‘p molekulali . Oqsillar strukturasining
o‘zaro yig‘ilishi ............................................................................................. 39
Turli a’zo oqsillarining funksiyasiga qarab har hil bo‘lishi, ontogenez va
kasalliklarda a’zolar oqsil tarkibining o‘zgarishi ........................................... 40
Biologik faol peptidlar ................................................................................... 42

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464
Izofunksional oqsillar ..................................................................................... 43
Oqsillarning ligandlar bilan o‘zaro ta’siri ...................................................... 44