International conference on bioinformatics of genome regulation

  
Yu.V. Rumyantseva, A.Z. Fursova, E.E. Korbolina, N.G. Kolosova 
260
COMPARATIVE ANALYSIS OF EXPRESSION OF ANHYDROBIOSIS-RELATED GENES 
IN RESPONSE TO DIFFERENT TYPES OF IONIZING RADIATION IN THE SLEEPING 
CHIRONOMID (POLYPEDILUM VANDERPLANKI) 
A.V. Ryabova, A.V. Cherkasov, K. Mukae, T. Kikawada, T. Okuda, T. Sakashita, O. Gusev
 
261
GRAPH DATABASE FOR HUMAN MICROBIOME 
 
A.A. Ryasik, E.A. Temlyakova, M.A. Orlov, A.A. Sorokin 
262
NEURONAL TRANSCRIPTIONAL REGULATION OF DROSOPHILA LIFE SPAN
 
O.Y. Rybina, A.V. Symonenko, N.V. Roshina, A.V. Krementsova, E.R. Veselkina, 
M.I. Schelkunov, S.V. Sarantseva, E.G. Pasyukova 
263
SEARCH FOR GENE MUTATIONS THAT CAN POTENTIALLY AFFECT THE SUSCEPTIBILITY  
TO TUBERCULOSIS
 
O.V. Saik, P.S. Demenkov, E.U. Bragina, M. Freidin, A. El-Seedy, R. Hofestaedt, V.A. Ivanisenko
 
264
ASSOCIATIVE NETWORKS OF GLAUCOMA AND APOPTOSIS
 
O.V. Saik, P.S. Demenkov, O.S. Konovalova, M.N. Ponomareva, N.A. Konovalova,  
N.A. Kolchanov, I.N. Lavrik, V.A. Ivanisenko
 
265
SLEEP OF REASON IN THE ANALYSIS OF THE RESULTS OF RESEARCH ON MATERIALS  
«PROTEOMIC INFORMATION OFSPRING WHEAT VARIETIES DIFFERING IN RESISTANCE  
TO INFECTION AFTER PUCCINIA RECONDITA INOCULATION»
 
K.N. Sarsenbayev, A. Sarsenbayeva 
266
MODULATION OF COGNITIVE FUNCTION BY OXIDATIVE DNA BASE LESION REPAIR
K. Scheffler, V. Rolseth, M.D. Bjorge, G. Hildrestrand, W. Wang, R. Suganthan,  
A. Kusnierczyk, C. Neurauter, H. Korvald, C. Vågbø, L. Luna, G. Slupphaug,  
L. Eide, M. Bjoras 
267
DISEASE MODELS FOR CANCER TO SELECT CANDIDATE BIOMARKERS AND DRUG TARGET
 
E. Schwartz, A. Yuryev, C. Ross, I. Riz, A. McPherron 
268
HUMAN BLOOD BISPECIFIC ANTIBODIES – NEW BIOCHEMICAL MARKERS OF AUTOIMMUNE  
DISEASES 
S.E. Sedykh, V.V. Printz, V.N. Buneva, G.A. Nevinsky  
269
PROTEOMIC ANALYSIS OF HORSE MILK EXOSOMES
 
S.E. Sedykh, L.W. Purvinsch, V.N. Buneva, G.A. Nevinsky  
270
PHYLOGENETIC ANALYS OF DAHPS II TYPE AMINOACID SEQUENCES
A.I. Semashko, E.G. Veremeenko, N.P. Maksimova 
271

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THE TENTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE\SYSTEMS BIOLOGY
TARGETED HIGH-THROUGHPUT SEQUENCING FOR MODY GENES IN WEST SIBERIA
E.V. Shakhtshneider, E.N. Voropaeva, D.E. Ivanoshchuk, A.K. Ovsyannikova, O.D. Rymar,  
Y.I. Ragino, M.I. Voevoda 
272
THE ROLE OF THE MECHANISMS OF RESISTANCE TO IONIZING RADIATION IN DROSOPHILA 
MELANOGASTER AGING AND LONGEVITY 
M.V. Shaposhnikov, E.N. Proshkina, L.A. Shilova, D.O. Peregudova, S.O. Zhikrivetskaya,  
A.A. Moskalev 
273
PATTERNS AND MECHANISMS OF CHROMOSOMAL EVOLUTION INFERRED FROM PHYSICALLY 
MAPPED GENOME ASSEMBLIES
I.V. Sharakhov, G.N. Artemov, A. Peery, X. Jiang, A.B. Hall, Z. Tu, A.N. Naumenko, 
V.N. Stegniy, M.V. Sharakhova 
274
GENOME AND CHROMOSOME EVOLUTION OF MOSQUITOES – VECTORS OF HUMAN DISEASES
M.V. Sharakhova, V.A. Timoshevskiy, A.N. Naumenko, A. Peery, G.N. Artemov, V.N. Stegniy,  
I.V. Sharakhov
 
275
DISSECTING VARIANCE HETEROGENEITY IN HUMAN SERUM METABOLOME
S.Zh. Sharapov, Y.A. Tsepilov, J.S. Ried, K. Strauch, C. Gieger, Y.S. Aulchenko
 
276
THE MITOCHONDRIAL GENE ORDER AND CYTB EVOLUTION IN HYMENOPTERA  
AND OTHER INSECTS
F.S. Sharko, A.V. Nedoluzhko, S.M. Rastorguev, A.A. Polilov, K.G. Skryabin, E.B. Prokhortchouk
 
277
THE INFLUENCE OF SNP RS201381696 OF A TATA BOX IN THE HUMAN LEP GENE ON EXPRESSION  
OF REPORTER GENE LUC
 
E.B. Sharypova,
 
E.V. Kashina, O.V. Arkova,
 
N.P. Bondar, T.V. Arshinova, P.M. Ponomarenko,  
M.P. Ponomarenko, L.K. Savinkova
 
278
THE OCCURRENCE OF SPRING FORMS IN TETRAPLOID TIMOPHEEVI WHEATS IS ASSOCIATED  
WITH VARIATION IN THE FIRST INTRON OF VRN-A1 GENE
 
A.B. Shcherban, A.A. Schischkina, E.A. Salina 
279
FREQUENCY OF GERMLINE MUTATIONS GENES CHEK, FANCL AND FANCI PATIENTS 
WITH BREAST CANCER IN THE REPUBLIC OF TATARSTAN
  
L. Shigapova, E. Shagimardanova, O. Gusev, A. Nikitin, M.Gordiev
 
280
IDENTIFICATION OF NUCLEAR GENES CONTROLLING CHLOROPHYLL SYNTHESIS  
IN BARLEY BY RNA-SEQ
 
N.A. Shmakov, G.V. Vasiliev, N.V. Shatskaya, A.V. Doroshkov, D.A. Afonnikov, E.K. Khlestkina
 
281
NICOTIANA GENOMICS: FROM PLANTS TO GENOMES
 
N. Sierro, J.N.D. Battey, S. Ouadi, N. Bakaher, L. Bovet, A. Willig, S. Goepfert, M.C. Peitsch, 
N.V. Ivanov
 
282
COMPARATIVE ANALYSIS OF GASTROINTESTINAL MICROBIOME IN WILD AND DOMESTIC QUAILS
 
M.N. Siniagina, M.I. Markelova, E.R. Kirillova, E.A. Boulygina, A.V. Lichoman,
, 
V.V. Radchenko
 
283
PHYLOGENETIC ANALYSES OF MYCOBACTERIUM TUBER-CULOSIS URAL FAMILY BY WGS  
DATA FROM EURASIA  
V. Sinkov, O. Ogarkov, Y. Bukin, I. Mokrousov, S. Zhdanova
 
284
DEVELOPMENT OF TISSUE-ENGINEERING CELL-SEEDED CHITOSAN-POLYCAPROLACTONE  
BLENDS FOR VASCULAR SURGERY
 
A.M. Smirnova, I.S. Zakharova
 
285
DIFFERENTIAL EXPRESSION OF GLYCOLYSIS-RELATED GENES IN HILAR CHOLANGIOCARCINOMA 
A.V. Snezhkina, D.V. Kalinin, M.S. Fedorova, O.L. Kardymon, I.Y. Karpova, A.F. Sadritdinova,  
N.V. Melnikova, A.A. Belova, M.M. Belyakov, O.S. Sudalenko, N.N. Volchenko, A.Y. Popov,  
K.M. Nyushko, A.D. Kaprin, B.Y. Alekseev, A.A. Dmitriev, G.S. Krasnov, A.V. Kudryavtsev 
286

21
THE TENTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE\SYSTEMS BIOLOGY
THE ROLE OF MIR-9 AND MIR-98 IN THE REGULATION OF HK2 GENE EXPRESSION  
IN COLORECTAL CANCER 
A.V. Snezhkina, I.Y. Karpova, O.L. Kardymon, A.F. Sadritdinova, M.S. Fedorova, N.V. Melnikova,  
O.A. Stepanov, K.M. Klimina, E.N. Slavnova, K.M. Nyushko, N.N. Volchenko, M.A. Chernichenko,  
D.V. Sidorov, D.V. Kalinin, A.Y. Popov, G.S. Krasnov, A.V. Kudryavtseva 
287
ANALYSIS OF A POWERFUL CONSTITUTIVE PROMOTER IN CULTURED CELLS OF POLYPEDILUM 
VANDERPLANKI
 
Y. Sogame, Y. Miyata, R. Deviatiiarov, S. Kikuta, R. Cornette, O. Gusev, T. Furusawa, T. Kikawada
 
288
DENOVO ASSEMBLY OF NUCLEAR GENOME OF THE SMALLEST INSECT MEGAPHRAGMA 
AMALPHITANUM (HYMENOPTERA: TRICHOGRAMMATIDAE)
 
A.S. Sokolov, A.V. Nedoluzhko, F.S. Sharko, E.S. Boulygina, S.V. Tsygankova, A.M. Mazur, 
A.A. Polilov, E.B. Prokhortchouk, K.G. Skryabin
 
289
GENETIC CONTROL OF CIRCADIAN RHYTHMS:AN IMPACT OF MOLECULAR CLOCK EXPRESSION 
PROFILE CHANGES IN LONGEVITY
 
I.A. Solovev, E.V. Dobrovolskaya, A.A. Moskalev
 
290
KYNURENIC ACID-SENSITIZED PHOTOLYSIS OF LENS PROTEINS UNDER ANAEROBIC CONDITIONS
 
E.D. Sormacheva, P.S. Sherin, E.A. Zelentsova, T.G. Duzhak, Yu.P. Tsentalovich, R.Z. Sagdeev
 
291
PARAMETER FITTING INFRASTRUCTURE FOR RULE-BASED MODELLING 
 
O.S. Sorokina, A.A. Sorokin 
292
VIROME ANALYSIS FOR IDENTIFICATION OF VIRUSES IN BAT SPECIES FROM MOSCOW REGION 
 
A.S. Speranskaya, E.V. Pimkina, I.V. Artyushin, M.V. Safonova, A.A. Deviatkin, K.V. Kuleshov,  
V.G. Dedkov, G.A. Shipulin
 
293
EXPGENE – SOFTWARE FOR ANALYSIS AND PROCESSING OF GENE EXPRESSION DATA
A.M. Spitsina 
294
PREDICTING SMALL RNAS FROM BACTERIAL GENOME
T. Stankovic, J. Guzina, M. Nikolic, M. Djordjevic  
295
IDENTIFICATION OF BACILLUS PUMILUS GROUP STRAINS BY MALDI TOF MS USING 
GEOMETRIC APPROACH
K.V. Starostin, E.A. Demidov, A.V. Bryanskaya, V.M. Efimov, A.S. Rozanov, S.E. Peltek 
296
CHANGES IN THE BRAIN TRANSCRIPTOME OF OXYS RATS AS THE SIGNS OF ALZHEIMER’S 
DISEASE DEVELOP AND EFFECTS OF SKQ1
N.A. Stefanova, N.I. Ershov, N.A. Muraleva, N.G. Kolosova 
297
ULTRASTRUCTURAL ANALYSIS OF MITOTIC DIVISION IN DROSOPHILA S2 CELLS
A.A. Strunov, L.V. Boldyreva, A.V. Pindyurin, M. Gatti, E. Kiseleva
 
298
ULTRASTRUCTURAL ANALYSIS OF SPINDLE AND KINETOCHORES IN AUGMIN-DEPLETED 
DROSOPHILA S2 CELLS
A.A. Strunov, L.V. Boldyreva, A.V. Pindyurin, M. Gatti, E. Kiseleva
 
299
MYC GENE FAMILY IN CEREALS: TRANSFORMATION IN THE COURCE OF THE TRITICUM  
AND AEGILOPS GENERA EVOLUTION
K.V. Strygina, E.K. Khlestkina 
300
IN SILICO MODELLING OF EXPERIMENTAL CHIP-SEQ PROCESS
T. Subkhankulova, F.M. Naumenko, Y.L. Orlov 
301
SINGLE CELL EXPRESSION PROFILING OF NEURAL CREST-DERIVED CELLS
T. Subkhankulova, G. Aquino, A. Rocco, H. Schwetlick, R.N. Kelsh
 
302
MOLECULAR PHYLOGENETIC ANALYSIS OF THE GRASSHOPPERS OF FAMILY ACRIDIDAE 
BASED ON SEVERAL MITOCHONDRIAL AND NUCLEAR MARKERS 
I.S. Sukhikh, A.G. Blinov, A.G. Bugrov  
303

22
THE TENTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE\SYSTEMS BIOLOGY
COMPREHENSIVE ANALYSIS OF DRAFT GENOMES OF TWO CLOSELY RELATED PSEUDOMONAS 
SYRINGAE PHYLOGROUP 2B STRAINS INFECTING MONO- AND DICOTYLEDON HOST PLANTS
R.I. Sultanov, G.P. Arapidi, S.V. Vinogradova, V.M. Govorun, D.G. Luster,
 
A.N. Ignatov 
304
ADAPTATION AND BIOLOGICAL TIME
V.V. Suslov  
305
TATA-BOX AND GENE EXPRESSION NORM OF REACTION
V.V. Suslov, M.P. Ponomarenko, D.A. Rasskazov  
306
VAVILOV’S HOMOLOGOUS SERIES AS EVOLUTIONARY FORCE 
V.V. Suslov, M.P. Ponomarenko, D.A. Rasskazov  
307
IDENTIFICATION OF PATHWAYS ASSOCIATED WITH CELL DEATH IN THE CORTEX OF OXYS  
RATS AS THE SIGNS OF ALZHEIMER’S DISEASE DEVELOP
G.K. Suvorov, D.V. Telegina, E.A. Rudnitskaya, N.A. Stefanova, N.G. Kolosova 
308
GENETIC POLYMORPHISM OF GLUTATHIONE S-TRANSFERASE P1 (GSTP1) AMONG BURYATS,  
TELEUTS AND RUSSIANS
 
L.E. Tabikhanova, L.P. Osipova, T.V. Churkina, H. Bai, E.N. Voronina, M.L. Filipenko 
309
THE ILE462VAL POLYMORPHISM OF THE CYTOCHROME P450 CYP1A1 GENE AMONG EASTERN 
BURYATS COMPARED WITH RUSSIANS IN TRANS BAIKAL AREA
L.E. Tabikhanova, L.P. Osipova, T.V. Churkina, E.N. Voronina, M.L. Filipenko
 
310
COMPUTER MODELLING OF INHIBITORS OF PROTEASE OF HUMAN HEPATITIS C VIRUS  
BASED ON KNOTTIN SCAFFOLD 
A.V. Talanova, D.S. Shcherbinin, E.F. Kolesanova, A.V. Veselovsky  
311
THE STRUCTURE OF GENETIC PREDISPOSITION TO TYPE 1 AND TYPE 2 DIABETES
N.V.
 
Tarasenko, I.A. Goncharova, A.V. Markov, V.P. Puzyrev 
312
FIGHTING WITH HIV-1 RESISTANCE TO REVERSE TRANSCRIPTASE INHIBITORS  
BY COMPUTER-AIDED APPROACH 
O.A. Tarasova, D.A. Karasev, D.A. Filimonov, V.V. Poroikov  
313
NUCLEOTIDE DIVERSITY ANALYSIS HIGHLIGHTS FUNCTIONALLY IMPORTANT GENOMIC REGIONS
T.V. Tatarinova, E. Chekalin, Y. Nikolsky, S. Bruskin, D. Chebotarov, K.L. McNally, N. Alexandrov  314
RELATIONSHIP OF CELL DEATH IN RETINA OF RATS DURING AGING WITH THE DEVELOPMENT  
OF RETINOPATHY
D.V. Telegina, O.S. Kozhevnikova, N.G. Kolosova  
315
SANGER DATA PROCESSING IN UNIPRO UGENE
A.V. Tiunov, E.A. Pushkova, Y.A. Algaer, G.A. Grekhov 
316
GENETIC BASIS OF AGGRESSION: CLUSTERIZATION OF EXPRESSION PROFILES
E.S. Tiys, A.O. Bragin, I.V. Medvedeva, I.V. Chadaeva, A.L. Markel, Y.L. Orlov 
317
GENEONTOLOGY BIOLOGICAL PROCESSES SENSITIVE TO SALT DIET CHANGES IN AN  
EXPREIMENT WITH 105-DAY ISOLATION: STATISTICAL ANALYSIS OF URINE PROTEOME
E.S. Tiys, E.D. Petrovskiy, L.Kh. Pastushkova, D.N. Kashirina, I.M. Larina, V.A. Ivanisenko
 
318
PHSYOLOGICAL AND TRANSCRIPTIONAL CHANGES IN A BLOSSAM-END ROT RESISTANT  
TOMATO INTROGRESSION LINE IL8-3 FRUIT
S. Tomoki, H. Ikeda, Y. Kanayama 
319
DIFFERENTIAL EXPRESSION OF SHAGGY, A DROSOPHILA MELANOGASTER GENE ENCODING  
GSK-3 BETA, AFFECTS LIFESPAN
M.V. Trostnikov, N.V. Roshina, E.G. Pasyukova 
320
ADDITIVITY AND NON-ADDITIVITY OF GENETIC CONTROL OF HUMAN METABOLOME
Y.A. Tsepilov, S. Shin, N. Soranzo, T.D. Spector, J. Adamski, G. Kastenmüller, K. Strauch,  
R. Wang-Sattler, C. Gieger, Y.S. Aulchenko, J.S. Ried 
321

23
THE TENTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE\SYSTEMS BIOLOGY
IDENTIFICATION OF BREED-SPECIFIC SNP-MARKERS FOR SUS SCROFA DOMESTICUS  
USING SRA-DATA OF NGS PROJECTS
I.S. Tsybovsky, V.N. Kipen, S.A. Kotova 
322
IDENTIFICATION OF THE TAXA OF THE ORDER ARTIODACTYLA FOR CRIMINAL INVESTIGATION 
CASES OF ILLEGAL HUNTING
I.S. Tsybovsky, S.A. Kotova, V.I. Rybakova, A.A. Rabcava, E.A. Spivak 
323
MOLECULAR EVOLUTION OF YUCCA PROTEIN FAMILY
  
I.I. Turnaev, V.V. Suslov, K.V. Gunbin, D.A. Afonnikov 
324
LOOKING FOR PROTEOMIC MARKERS OF BREAST CANCER IN BLOOD EXOSOMES  
O.S. Tutanov, S.N. Tamkovich, Y.S. Bakakina, L.V. Dubovskaya, Y.P. Tsentalovich, I.D. Volotovskiy,  
P.P. Laktionov
 
325
MITOCHONDRIAL DYSFUNCTION IN SPORADIC ALZHEIMER’S DISEASE-LIKE PATHOLOGY  
IN OXYS RATS 
M.A. Tyumentsev, E.V. Kiseleva, V.A. Vavilin, N.G. Kolosova, N.A. Stefanova
 
326
REGULATION OF RIPKS IN CELL SURVIVAL AND CELL DEATH BY APOPTOSIS AND NECROPTOSIS, 
INSIGHTS AND THERAPEUTIC POTENTIAL 
P. Vandenabeele
 
327
MUTATIONS SPECTRA OF MAJOR ONCOGENES IN PATIENTS WITH MULTIPLE PRIMARY NEOPLASIA 
G.V. Vasiliev, A.V. Savkova, A.V. Gerasimov
 
328
PARASITES OF THE GENERA NOSEMA, APICISTIS, CRITHIDIA AND LOTMARIA IN THE NATURAL 
HONEYBEE AND BUMBLEBEE POPULATIONS: A CASE STUDY IN INDIA 
V. Vavilova, I. Konopatskaia, M. Woyciechowski, S. Luzianin, A. Blinov
 
329
EFFECTS OF LAMBERTIANIC ACID AMIDE ON EPILEPTIFORM ACTIVITY IN HIPPOCAMPAL  
SLICES INDUCED BY PICROTOXIN OR MAGNESIUM-FREE MEDIUM 
S.O. Vechkapova, A.L. Proskura, T.A. Zapara, E.D. Sorokoumov, A.S. Ratushnyak 
330
ARGO_CUDA: A FULL-EXHAUSTIVE GPU BASED APPROACH FOR A MOTIF DISCOVERY  
IN THE LARGE DNA DATASETS
O.V. Vishnevsky, A.V. Bocharnikov, N.A. Kolchanov
 
331
THE IMPACT OF HUMAN GENETIC VARIABILITY ON LIGAND-PROTEIN INTERACTIONS  
AND INDIVIDUAL DRUG RESPONSE 
P.K. Vlasov, O. Pich I Rosello, A.V. Vlasova, F.A. Kondrashov 
332
CHARACTERISTICS OF ACDS-GENE OF BACTERIA PSEUDOMONAS PUTIDA B-37 RESPONSIBLE  
FOR ACC-DEAMINASE SYNTHESIS 
D.S. Volkava, S.I. Leanovich, A.A. Melnikava, E.A. Khramtsova 
333
AMPLISEQ ™: AMPLIFICATION AND SEQUENCING 
I.A. Volkov 
334
COUPLED MOLECULAR DYNAMIC AND CONTINUUM ELECTROSTATIC METHOD TO COMPUTE 
IONIZATION OF PROTEINS AS A FUNCTION OF PH  
Yu.N. Vorobjev 
335
METHODS TO CALCULATE P-VALUE OF RNA OF A DEFINITE SHAPE 
D.G. Vorobyev, V.V. Solovyev 
336
HOCOMOCO COMPREHENSIVE MODEL COLLECTION AS A PRACTICAL GATEWAY TO REGULATORY 
MOTIF-OME OF HUMAN AND MOUSE TRANSCRIPTION FACTORS 
I.E. Vorontsov, Y.A. Medvedeva, V.J. Makeev, I.V. Kulakovskiy 
337
THE FREQUENCY, SPECTRUM AND FUNCTIONAL SIGNIFICANCE OF MUTATIONS IN CODING 
SEQUENCE OF TP53 GENE IN RUSSIAN PATIENTS WITH DLBCL 
E.N. Voropaeva, T.I. Pospelova, M.I. Voevoda, V.N. Maximov
 
338

24
THE TENTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE\SYSTEMS BIOLOGY
HOW SEQUENCE AND STRUCTURE AFFECT THE MIRNA MATURATION 
P.S. Vorozheykin, I.I. Titov
 
339
DRAFT GENOME SEQUENCE OF STREPTOMYCES SP. IB 2014 011-1 ISOLATED FROM LAKE BAIKAL 
MACROINVERTEBRATES 
I.V. Voytsekhovskaya, D.V. Axenov-Gribanov, B.T. Tokovenko, Y.V. Rebets, E.S. Protasov,  
A.N. Luzhetskyy, M.A. Timofeyev
 
340
ACTUAL APPROACHES FOR QUALIFICATION AND QUANTIFICATION OF PROTEOME CHANGES 
E.P. Vrzheschch 
341
MULTIDIMENSIONAL PATTERNS OF METABOLIC RESPONSE IN ABIOTIC STRESS-INDUCED  
GROWTH OF ARABIDOPSIS THALIANA 
B.S. Yadav, S. Freilich, E. Katz, A. Finkelshtein, D.A. Chamovitz
 
342
OPTIMIZATION OF THE PIGGYBAC TRANSPOSON SYSTEM FOR CULTURED DROSOPHILA CELLS 
L.A. Yarinich, M.O. Lebedev, A.V. Pindyurin
 
343
GTRD – GENE TRANSCRIPTION REGULATION DATABASE 
I.S. Yevshin, R.N. Sharipov, Yu.V. Kondrakhin, F.A. Kolpakov 
344
ASSESSMENT OF TRANSLATION EFFICENCY FROM RIBOSOME PROFILING AND MRNA-SEQ DATA 
I.S. Yevshin, R.N. Sharipov, O.A. Volkova 
345
STRUCTURAL BIOINFORMATICS OF FPG GLYCOSYLASE: SEARCH FOR SUBSTRATE SPECIFICITY  
IN THE SEQUENCE SPACE 
A.V. Yudkina
 
346
IN SILICO DESIGN OF APTAMERS CONTAINING G-QUADRUPLEXES 
A.O. Zalevsky, A.O. Demkiv, A.V. Golovin
 
347
DISTINCT TYPES OF EIN3-DNA INTERACTIONS IN VARIOUS FUNCTIONAL REGIONS  
OF A. THALIANA L. GENOME 
E.V. Zemlyanskaya, D.Yu. Oshchepkov, V.G. Levitsky
 
348
ELEMENTAL METABOLOMICS – LINKING ENVIRONMENTAL, FOOD, NUTRITION AND HEALTH 
SCIENCES  
P. Zhang, I. Giannenas, C.A. Georgiou, V. Brusic  
349
SPEED READING AT THE MOLECULAR SCALE: HOW ENZYMES FIND TYPOS IN A DNA TEXT 
D.O. Zharkov 
350
PHYLOGENETIC RECONSTRUCTION WITHIN MYCOBACTERIUM TUBERCULOSIS BEIJING  
GENOTYPE IN NORTHEASTERN RUSSIA 
S. Zhdanova, O. Ogarkov, G. Alexeeva, M. Vinikurova, E. Savilov, V. Sinkov
 
351
CHEMORESISTANCE OF LUNG ADENOCARCINOMA IS REGULATED BY TUDOR  
STAPHYLOCOCCAL NUCLEASE 
B. Zhivotovsky
 
352
COMPUTER SIMULATION OF TRICHOME PATTERNING ON GROWING WHEAT LEAF TAKING 
INTO ACCOUNT THE BIOMECHANICS OF CELLS 
U.S. Zubairova, S.V. Nikolaev, A.V. Penenko, N.L. Podkolodnyy, S.K. Golushko, 
D.A. Afonnikov, N.A. Kolchanov
 
353
AN IMAGEJ PLUGIN FOR DETECTION OF WHEAT LEAF EPIDERMIS CELLULAR STRUCTURE 
FROM CONFOCAL LASER SCANNING MICROSCOPY 
U.S. Zubairova, P.Yu. Verman, A.V. Doroshkov
 
354
ALTORFEV: A NOVEL TOOL FOR PREDCITION OF ALTER
NATIVE ORFS BASED 
ON THE LINEAR SCANNING MODEL 
B.S. Zuraev, A.V. Kochetov, A.I. Klimenko, S.A. Lashin
 
355
AUTHOR INDEX 
356

25
THE TENTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE\SYSTEMS BIOLOGY
SMALL MOLECULE AGONISTS OF RELAXIN RECEPTOR
A.I. Agoulnik
1
*, I.U. Agoulnik
1
, X. Hu
2
, C. Myhr
1
, Z. Huang
1
, B.A. Ho
1
, E. Barnaeva
2
, 
J. Xiao
2
, M. Ferrer
2
, N.T. Southall
2
, J.J. Marugan
2
1 
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA; 
2
NIH Chemi-
cal Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 
Rockville, MD, USA
* Corresponding author: [e-mail]
Key words: relaxin peptide, RXFP1 GPCR, small molecule agonist
Aim: The  anti-fibrotic,  vasodilatory,  and  angiogenic  therapeutic  properties  of  relaxin 
peptide have been shown in several animal models of human diseases and in clinical tri-
als. The aim of the study was to identify stable and bioavailable small molecule agonists 
of relaxin G protein-coupled receptor, RXFP1.
Methods and Algorithms: High-throughput screening (HTS) of small molecule library, 
structure-activity relationship (SAR) studies, ligand-receptor interaction modeling, site-
specific mutagenesis, transgenic animal studies.
Results: We discovered the first series of small molecule agonists of RXFP1 using HTS 
followed by SAR optimization. The compounds are selective RXFP1 agonists with low 
cytotoxicity, excellent in vitro ADME, and in vivo pharmacokinetic properties. These 
molecules display efficacy similar to the natural hormone in several functional assays in 
vitro [1]. The agonists did not activate rodent receptors but produced response in cells 
transfected with human, macaque, pig, and rabbit RXFP1 [2]. Computational modeling 
in combination with site-directed mutagenesis studies indicated that the small molecules 
activated relaxin receptor through an allosteric site and did not compete with the relaxin 
binding to RXFP1 [3]. Analysis showed that the small molecule agonist binds to RXFP1 
in a manner similar to the agonist binding complex of β2AR. Unique to RXFP1, how-
ever, is the involvement of extracellular loop 3 (ECL3) of 7TM domain whose extensive 
H-bonding is crucial to the observed selectivity of the compounds for RXFP1 over other 
related receptors. To test agonists’ activity in vivo we produced mice with human RXFP1 
receptor. 
Conclusion: The first potent, selective, and bioavailable small molecule agonists for re-
laxin receptor RXFP1 were identified. Mutagenic and modeling studies indicate that the 
agonists use allosteric binding to the transmembrane region of the receptor. Understand-
ing the structural basis and molecular mechanism of activation and selectivity of the 
RXFP1 agonists provides useful information for future optimization of the lead series.
Acknowledgements: Supported by NIH (R03MH085705, 1U01CA177711), Florida De-
partment of Health (3KFO1) grants, and NIH Roadmap for Medical Research.
References:
1  Xiao et al. (2013) Identification and optimization of small-molecule agonists of the human relaxin 
hormone receptor RXFP1. Nature Comm, 4:1953.
2.  Huang  et  al.  (2015). Activation  of  Relaxin  Family  Receptor  1  from  different  mammalian  species 
by relaxin peptide and small molecule agonist ML290. Front. Endocrinol. 2015, doi: 10.3389/fen-
do.2015.00128.
3.  Hu et al. Structural insights into the activation of human relaxin family peptide receptor 1 by small 
molecule agonists. Biochemistry, 55:1772-83.

26
THE TENTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE\SYSTEMS BIOLOGY
THE ROLE OF FUNCTIONAL DOMAINS OF DROSOPHILA 
SEPTIN PNUT
K.A. Akhmetova
1, 2, 3
*, N.V. Dorogova
1
, M.L. Balasov
3
, S.A. Fedorova
1, 2
, I.N. Chesnokov
3
1
 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
2
 Novosibirsk State University, Novosibirsk, Russia
3
 University of Alabama at Birmingham, Birmingham, USA
* Corresponding author: [e-mail]